Abstract
Tissue integration of the dental implant involves the establishment of soft tissue sealing as a result of wound healing, which serves as an effective barrier against bacterial penetration. The implant lacks cementum; however, the collagen fiber bundles are arranged parallel to the implant surface with fewer attachments by hemidesmosomes that is suggestive of a poorer quality attachment. Certain features of the transmucosal abutment such as the material characteristics, surface topography, and implant components and connections are important factors for obtaining an effective seal. In this study, we evaluated the soft tissue healing according to the characteristics of abutment surface based on a review of the current literature.
Key Words: dental implant, soft tissue-implant interaction, wound healing
⺤ㄦ⬚コ⼥⩔⼅⺘⯯⼩⻌ゴⴓ⸔⫂⮆⸟⻥⼦⺀⺘⾄⺝
⯭ㅈ⻌⣞⾈
⺝⼧ ⾄⺸⤈ ⺝⼎ⴇ⺝⪆⻓⺘⺀⻓ⷛ⭼⺸⼇⿁ⴓㅤ
1연세대학교 치과대학 치주과학교실, 치주조직재생연구소, 2중앙보훈병원 치과병원 치주과, 3고려대학교 안암병원 치과
Soft Tissue Healing on Dental Implant Abutments: A Literature Review
Jin-Wook Lee1,2,*, Jae-Kook Cha1,*, Jung-Seok Lee1, Dong-Woon Lee2, Ui-Won Jung1, Jung-A Yu2, Jae-Jun Ryu3, Seong-Ho Choi1
1Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea
2Department of Periodontology, Dental Hospital, Veterans Health Service Medical Center, Seoul, Korea
3Department of Dentistry, Korea University Anam Hospital, Seoul, Korea
ISSN 1229-5418 Implantology 2015; 19(3): 170~177
Reprint requests: Seong-Ho Choi
Department of Periodontology, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
Tel: 82-2-2228-3189, Fax: 82-2-392-0398 E-mail: [email protected]
Received for publication: April 19, 2015 Revised for publication: June 9, 2015 Accepted for publication: June 10, 2015
교신저자: 최성호
(03722) 서울시 서대문구 연세로 50-1 연세대학교 치과대학 치주과학교실 Tel: 82-2-2228-3189, Fax: 82-2-392-0398 E-mail: [email protected]
원고접수일: 2015년 4월 19일 원고수정일: 2015년 6월 9일 게재확정일: 2015년 6월 10일
Copyright © 2015. The Korean Academy of Oral & Maxillofacial Implantology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
*These authors contributed equally to this work as first authors.
** 결과
1. 치아와 임플란트 주위 조직의 질적·양적 차이
ᔾྜྷ⦺ᱢ⡎Ğ
⊹ᦥ⊹ᮡ݉᭥۵đ⧊᳑Ḣ᮹ᇡ₊ᇡ᪡ᔢ⦝᮹ᇡ₊
ᇡಽǍᇥࡽ֥݅(BSHJVMP॒ᮡÕv⦽ᔍ௭
ᮥ᳑ᔍ⦽đŝ⊹᳑ʼnᱶ đ⧊᳑Ḣᇡ₊ ᔢ⦝ᇡ₊
ᔍᯕᨱ۵ᯝᱶ⦽እᮉᯕ᳕ᰍ⦽݅Ł⦹ᩡᮝ໑ ⊹ᮡᩕǍ ۵⠪ɁNN ᔢ⦝ᇡ₊ᇡ۵⠪ɁNN đ⧊᳑
Ḣᇡ₊ᇡ۵⠪ɁNN⦹ᩡ݅ᯝၹᱢᮝಽᔢ⦝
ᇡ₊ᇡ᪡đ⧊᳑Ḣᇡ₊ᇡෝ⧊⦽äᮥᔾྜྷ⦺ᱢ⡎Ğ CJPMPHJDXJEUIᯕ⦹໑⠪ɁNNᱶࠥᯕ݅
⦽⠙ #FSHMVOEI॒ᮡ࠺ྜྷᝅ⨹ᨱᕽᯥ⥭✙ᵝ᭥
ᱱส᮹⧕ᇡ⦺ᱢၰ᳑Ḣ⦺ᱢᯙ✚Ḷᮥ᳑ᔍ⦹ᩡ݅᳑
Ḣ⦺ᱢáᔍđŝ⊹ᮡŝᯥ⥭✙ᵝ᭥ᱱสᮡŖ☖ᱱ
ᮥaḡ۵äᮝಽӹ┡ԍ݅⊹ᮡǍvᔢ⦝۵b⪵ࡹ
ᨕᯩᨩŁ ႒ᦦჶ௲ĞĥᨱᕽҾӹ۵᧨ᮡᱲ⧊ᔢ⦝᪡
ᩑđࡹᨕᯩᨩ݅ᯥ⥭✙ᵝ᭥ᱱสࠥb⪵ᔢ⦝ᨱ᮹
⧕ߏᩍᯩᨩᮝ໑Ǎvᔢ⦝᮹ᄡᩑĞĥ۵ḡݡᵝᇡ᭥
ᨱᱲ⧕ᯩ۵ᔢ⦝᪡ᩑđࡹᨕᯩᨩ݅ᯥ⥭✙ᵝ᭥ᱲ
⧊ᔢ⦝۵⊹š⊂ᩑ᳑Ḣᄡᩑᨱᕽ⊹ɝ݉NN ᯥ⥭
✙ᵝ᭥⊹᳑ᱶᮝಽᇡ░۵_NN⊹š⊂ᨱᕽ᳦đ
ࡹᨩ݅᧞⦹໕ᔾྜྷ⦺ᱢ⡎Ğŝ ⊹ᮡᩕǍ᮹ʫᯕෝ
⦽⠪Ɂsᮡᯥ⥭✙ᵝ᭥ᨱᕽ᧞NN ⊹ᦥᵝ᭥
᧞NNಽᯥ⥭✙ᨱᕽⓍíӹ┡ԍ݅
ᯥ⥭✙᮹ᰆʑᱢᯙᖒŖᮥ᭥⧕ᕽ۵ᦩᱶᱢᯙ
ʼnᮁ₊ᐱอᦥܩᯥ⥭✙ᵝ᭥ᔢ⦝᪡đ
⧊᳑Ḣ᮹᪥ᱥ⦽ၡ⠱a⦥ᙹᱢᮝಽ࠺ၹࡹᨕ
⦽݅ᩑ᳑Ḣ᮹ၡ⠱۵ᯥ⥭✙ᵝ᭥᮹ၶ▭ญᦥ⋉
⚍ෝส۵ᔾྜྷ⦺ᱢႊᨕสᮝಽ᯲ᬊ⦹໑ᩍ్ᖁ⧪ᩑ Ǎॅᮥ☖⧕ᯕ۵ᰆʑᱢᮝಽᦩᱶᱢᮝಽᮁḡࢁᙹᯩ
݅Łၾ⩡Ჭ݅
ᯱᩑ⊹ᦥ᪡ᯥ⥭✙ᵝ᭥ᩑ᳑Ḣᮡᯥᔢᱢ ᳑Ḣ⦺
ᱢᮝಽᮁᔍᖒᮥᅕᯕḡอ₉ᯕᱱ᳕ࠥᰍ⦽݅ᯕ్⦽
₉ᯕ᮹ᵝࡽᯕᮁ۵⊹ɝ໕႒ᦦḩ᮹ᮁྕᨱᕽʑᯙ⦽
݅ ᯱᩑ⊹᮹ Ğᬑ ᱲ⧊ᔢ⦝ᨱ ᮹⧕ Ḣᱲᱢᯙ ᇡ₊
BUUBDINFOUᯕࡹᨕᯩ۵ၹ໕ ᯥ⥭✙۵Ḣᱲᱢᯙᇡ
₊ݡᝁᱱ₊ BEIFTJPOᨱ᮹⧕ၡ⠱ࡽ݅əญŁđ⧊
᳑Ḣԕ᮹Ʊᬱᖍᮁ᮹ᵝ⧪ႊ⨆ᯕ⊹ᦥ᮹Ğᬑᰆ⇶ᨱ
ᙹḢ⦽ႊ⨆ᮝಽ႒ᦦḩᨱᔞ᯦ࡹ۵ၹ໕ ᯥ⥭✙۵
ᰆ⇶ᨱ⠪⧪⦹íᵝ⧪⦽݅
ᯥ⥭✙ᵝ᭥ᩑ᳑Ḣ᮹⊹ᮁᨱᩢ⨆ᮥၙ⊹۵ᯙᮝ ಽ۵Ⓧíᙹᚁᱢᯙŝᅕ℁ᱢᯙᯕᯩᮝ໑ ᅕ℁ᱢ
ᯙᵲᯥ⥭✙ᱱสš☖ᇡᇥ᮹ྜྷḩᱢ✚ᖒᯕᰆʑ ᱢᦩᱶᖒᨱⓑᩢ⨆ᮥၙ⊽݅Ł⦹ᩡ݅⢽໕⩶┽ Ñ
⋁ʑ ⊽ᙹᖒ॒ᮥ⡍⧉⦹۵ྜྷḩᱢ✚ᖒᮡ⊹ᮡᖍᮁ༉
ᖙ⡍᮹ၹ᮲ᨱᩢ⨆ᮥᵝ۵äᮝಽಅᲙᕽ↽ɝʭḡ
ฯᮡᩑǍᯱॅᨱ᮹⧕⪽ၽ⯩ᩑǍࡹŁᯩ۵ᇥᯕ݅
ੱ⦽↽ɝᩑǍᨱᕽ۵ḡݡᵝ᮹⢽໕ญෝ☖⧕ʕᱲ
⧊ᔢ⦝᪡đ⧊᳑ḢԕƱᬱᖍᮁ᮹ᵝ⧪ᮥႊ⧕ੱ۵ᄡ
⪵┕ᮝಽ៉ᯥ⥭✙ᵝ᭥ʼn⯂ᙹෝႊḡ⦹۵ࠥࠥ
ᯕᨕḡŁᯩ݅
ᕽᯕםྙ᮹༊ᱢᮡ⩥ᰍʭḡၽ⢽ࡽྙ⨭ᮥ☖
⧕⊹ᦥ᪡ᯥ⥭✙ᵝ᭥᳑Ḣ᮹₉ᯕᱱᮥᦥᅕŁ ᯥ
Review Article
đ⧊᳑Ḣᇡ₊
⊹ᦥ᪡ᯥ⥭✙᮹ᵝࡽ₉ᯕ۵႒ᦦḩ᮹ᮁྕ⧁
ᙹᯩ݅⊹ᦥᨱᕽ۵႒ᦦḩಽᇡ░⠪⧪⦹Ñӹᔍᖁᮝಽ
⊹ᦥ⊹ᮡ ⊹ᦥ⊹᳑ᱶႊ⨆᮹Ʊᬱᖍᮁ݅ၽᯕጸᨕ ӹaᖙɁ᮹⋉᯦ᮝಽᇡ░ႊᨕᄞ᮹ᩎ⧁ᮥ⦹íࡽ݅
ၹ໕ᨱᯥ⥭✙ᨱ۵႒ᦦḩᯕ᳕ᰍ⦹ḡᦫᮝအಽᖍᮁ
݅ၽᮡᯥ⥭✙⢽໕ᨱᔞ᯦ࡹḡᦫᮝ໑ ᯥ⥭✙⢽
໕ᨱ⠪⧪⦹íᵝ⧪⦽݅ੱ⦽ᯥ⥭✙ᵝ᭥᮹⠪⪽ḡ ݡᵝ⢽໕ᨱᯩ۵⊹᳑ʼnᔢႊᇡ᮹đ⧊᳑Ḣᨱᕽ۵⊹ᦥ ᮹ᵝ᭥᳑Ḣᨱᕽᅕ݅ᱢᮡᖍᮁ༉ᖙ⡍᪡ฯᮡƱᬱᖍᮁ
ašₑࡽ݅đŝᱢᮝಽᯥ⥭✙ᨱᕽ᮹đ⧊᳑Ḣᇡ
₊ᮡᯱᩑ⊹ᦥᨱᕽᅕ݅᧞⦽ʑĥᱢᱡ⧎ᮥwíࡽ݅
⩩šᇥ⡍
⊹ᮡ᮹⩩šᇥ⡍۵Ⓧíࢱaḡ᮹݅ෙʑᬱᮥw۵
݅ℌṙ۵ⓑʼnสᔢႊ⩩šᯕ໑ࢱჩṙ۵⊹ᵝᯙݡ᮹
⩩šⅾᯕ݅ᯕ᪡۵݅íᯥ⥭✙ᵝ᭥ᱱส᮹⩩š ℕĥ۵⊹᳑ᱶᔢႊᇡ᮹⦹ӹ᮹ⓑʼnสᔢႊ⩩šᮝಽᇡ
░ᮁ௹ࡹᨕᯥ⥭✙ḡݡᵝ⢽໕ᮝಽᇥḡa⨆⦹۵
äᮝಽ ӹ┡ԍ݅ ੱ⦽ ᯥ⥭✙ ⢽໕ŝ ɝᱲ⦽
_ⱡNÑญᨱᕽ۵⩩šᯕšₑࡹḡᦫᦹᮝ໑ ᯥ
⥭✙⢽໕ŝຝᱲ⧊ᔢ⦝ ᩕǍᔢ⦝᪡ɝᱲ⦽ᩢᩎᨱ ᕽ⩩šᯕšₑࡹᨩ݅ᕽ⩩š᮹ᙹ۵ᯥ⥭✙⢽
໕ᮝಽᇡ░ມᨕḩᙹಾ᷾a⧉ᮥᙹᯩ݅ᯱᩑ⊹ᦥ
᪡እƱ⦹ᩍ ⊹᳑ʼnᔢႊᇡ᮹ᯥ⥭✙᪡ɝᱲ⦽đ⧊
᳑Ḣᇡᨱᕽᱢᮡᙹ᮹⩩šᯕšₑࡹᨩ݅đŝᱢᮝಽ
⊹ᦥᨱእ⧕ᯥ⥭✙ᵝ᭥ᩑ᳑Ḣ᮹໕ᩎၹ᮲ᯕᔢݡ ᱢᮝಽԏᮥᙹᯩ݅
┱⋉⊹ᵝԎʫᯕ
}ᨱᕽ᮹ᩑǍᨱᕽ/᮹⯹ᮝಽ┱⋉ᮥ⧪⦹ᩡᮥ
ভ ┱⋉⊹ᵝԎʫᯕ۵ᯥ⥭✙ᵝ᭥᳑Ḣᨱᕽ⠪Ɂ
NNʫíӹ┡ԍ݅ᱩ⠙᮹᳑Ḣ⦺ᱢáᔍđŝ
┱⋉ᮡᱲ⧊ᔢ⦝᮹ɝ݉⊂Ҿᨱ᭥⊹⦹۵äᮝಽӹ┡ԍ
݅-BOH॒ᮡእɡčᨱᕽᯥ⥭✙ᵝ᭥᳑Ḣ᮹Õv ᔢ┽ᨱෙ⊹ᵝ┱⋉݉᭥⊹᮹₉ᯕෝᅕŁ⦹ᩡ݅ᯥ
⥭✙ᵝ᭥᳑ḢᯕÕv⦹Ñӹᯥ⥭✙ᵝ᭥ᱱสᩝᯕ
ᯩ۵ᇡ᭥ᨱᕽ۵⊹ᵝ┱⋉݉ᯕđ⧊᳑Ḣᇡ₊ᙹᵡᨱ
ᯩ۵ၹ໕ ᯥ⥭✙ᵝ᭥ᩝᇡ᭥ᨱᕽ۵⊹ᵝ┱⋉ᯕ⊹
ᵝԎᔢ⦝᮹ʑᱡᇡෝḡӹ⠪ɁNNᱶࠥʫí
ᔞ᯦ࡹᨩ݅ ᔍ௭ᮥ ݡᔢᮝಽ ⦽ ᩑǍᨱᕽ۵
_NNჵ᭥᮹sᮝಽ⊹ᦥᨱᕽᅕ݅ᯥ⥭✙ᨱᕽ
┱⋉ʫᯕaʫíӹ┡ԍ݅
&UUFS॒ᮡ❑┡ۥ⥭ᜅษᬊᔍᯥ⥭✙ᵝ᭥ᨱᕽ
ᯥᔢᱢᯙ┱⋉᮹đŝಽᗱᔢࡽᩑ᳑Ḣ⊹ᮁᨱݡ⦹ᩍ
ၽ⢽⦹ᩡ݅┱⋉ᯕᯥ⥭✙ᵝ᭥ᱲ⧊ᔢ⦝᮹aᰆɝ
݉⊂ᖙ⡍ʭḡḡӹaḡอ đ⧊᳑ḢǍ⫮ᨱᕽ۵᳑Ḣ
ᇥญaၽčࡹḡᦫᦹ݅ᯕᩑǍᨱᕽᯥ⥭✙ᯙᱲᔢ
⦝ᇡ₊᮹⊹ᮁ۵ᯥᔢᱢ┱⋉ᯝ⬥ᨱ᪥ᖒࡹᨩ݅ə
్အಽ┱⋉ᮡᯥ⥭✙ᵝ᭥ᱱส᮹Õvᮁḡෝᱡ⧕⦹
۵äᮝಽᅕᯕḡᦫ۵݅⦽⠙ ੱ݅ෙ࠺ྜྷᩑǍᨱᕽ ۵⊹ᮁ݉ĥ࠺ᦩṈᮡeĊ᮹ᰇᮡᯥᔢᱢᯙ┱⋉ᮡᯥ
⥭✙ᵝ᭥ᱱส᮹Ǎ᳑ᱢᯙᄡ⪵ෝⅩ௹⧁ᙹᯩ݅Ł
ᅕŁࡽၵᯩ݅
2. 임플란트 표면 특성에 따른 연조직 치유 의 차이
ᯥ⥭✙ᵝ᭥ᩑ᳑Ḣ᮹⊹ᮁ۵ᔢᵝ᭥ᱱสᨱᕽ
ᮁ௹⦽ᔢ⦝᮹⦹ႊ᷾ŝᯕᵝᨱ᮹⧕᯲ࡹ໑᧞
NNࢱ̹᮹ᱲ⧊ᔢ⦝ෝ⩶ᖒ⦹íࡽ݅ ᷪ ᰆʑᱢᯙ
ᩑ᳑Ḣၡ⠱᮹ᮁḡෝ᭥⧕ᕽ۵ᔢ⦝᮹⦹ႊᯕᵝෝᨖ ᱽ⦹Ł࠺ᨱđ⧊᳑Ḣ᮹ᇡ₊ᮥ᷾ḥ┅۵äᯕᵲ
⦹݅ᯕŝᱶᨱᕽᔢ⦝ၰᱱสš☖ᇡᇥŝᱲⅪ⦹Łᯩ
۵⩩ᄲၰᮂᦥ᳑Ḣ᮹᳕ᰍaᔢ⦝᮹⦹ႊᯕᵝෝᱽ⦽
⦹۵ᵝࡽᗭಽ᯲ᬊ⦹۵äᮝಽӹ┡ԍᮝ໑ ᕽ
ᱲ⧊ᔢ⦝᮹᭥⊹۵ᯥ⥭✙พ⬥Ⅹʑ⊹ᮁŝᱶᨱᕽ
ḡݡᵝ᮹ྜྷḩᱢ✚ᖒᨱෙ₉ᯕ
พࡽᯥ⥭✙᪡zᮡᇡ᳑Ḣᨱݡ⦽ᖙ⡍ၹ᮲
ᮡᯕℕ᮹ྜྷḩᱢ✚ᖒၰ⪵⦺ᱢǍᖒᨱᩢ⨆ᮥၼ۵
݅"CSBIBNTTPO॒ᮡ}ෝᯕᬊ⦽ᩑǍᨱᕽᙽᙹ❑
┡ۥ ᖙၚḡݡᵝ "M0᮹Ğᬑᨱᔢ⦝᪡đ⧊᳑Ḣᮝ ಽᯕᨕḥ_NN᮹ᱱสᇡ₊ᮥ⩶ᖒ⦹ᩡᮝӹ ɩ⧊ɩḡݡᵝ᪡⊹ŝᬊࠥᰍḡݡᵝ᮹Ğᬑᨱ۵ᱢᱩ
⦽ᇡ₊ᮥ⩶ᖒ⦹ḡ༜⦹ᩡŁ ᩑ᳑Ḣᄡᩑᯕ♕⇶ࡹᨕ
ʼn⯂ᙹෝʑ⧉ᮥᅕŁ⦹ᩡ݅3äJTäOFO॒ᮡ❑┡ۥ
❑┡ۥ⧊ɩ 5J "M 7 HSBEF ⊹ŝɩ⧊
ɩ "V "H $V 1E ;O 3V< ᔑ⪵ၙۥ "M0⊹ŝᬊࠥᰍbb ᨱݡ⦽ᔢ⦝ᖙ⡍᮹ᇡ₊ᨱݡ⧕ᔾℕᨱᕽᵝᔍᱥᯱ
⩥ၙĞŝ໕ᩎ⩶Ųჶᮥᯕᬊ⦹ᩍšₑ እƱ⦹ᩡ݅ᔢ
⦝ᖙ⡍۵ᖙၚ⢽໕ ᔑ⪵ၙۥ ⊹ŝᬊࠥᰍᅕ݅
ɩᗮ⢽໕ ❑┡ۥ ❑┡ۥ⧊ɩ ⊹ŝɩ⧊ɩᨱմŁ
v⦹íᇡ₊ࡹᨩ݅ੱ⦽,PIBM॒ᮡ❑┡ۥŝḡ⎵
ܩᦥḡݡᵝ⢽໕ᨱᕽ༉ࢱ᧲⪙⦽ᩑ᳑Ḣᇡ₊ᯕ⩶ᖒ
ࡹŁᯕ۵}ᬵᯕᔢḡᗮࡹḡอ ɩ႒ɩḡݡᵝ۵ᔢ
⦝᮹⦹ႊ᷾ᯕᯕᨕḡ໑ᄡᩑʼnᗭᝅᯕᯝᨕӽ݅Ł
⦹ᩡ݅
⦽⠙ 7JHPMP॒ᮡᔍ௭᮹݉ᯝᯥ⥭✙ෝݡᔢᮝಽ
❑┡ۥŝɩ⧊ɩḡݡᵝeᩑ᳑Ḣ⊹ᮁ᮹₉ᯕෝእƱ
⦹ᩡ۵ߑ ☖ĥᱢᮝಽᮁ᮹⦽₉ᯕ۵ӹ┡ӹḡᦫᦹ݅
-JOLFWJDJVT᪡"QTF۵❑┡ۥ ɩ⧊ɩ ḡ⎵ܩᦥၰ
ᖙၚḡݡᵝෝݡᔢᮝಽᯥ⥭✙ᵝ᭥ᩑ᳑Ḣᦩᱶᖒ ᨱš⦽ญቑםྙᮥၽ⢽⦹ᩡ۵ߑ ❑┡ۥḡݡᵝaᩑ
᳑Ḣᦩᱶᖒ໕ᨱᕽ݅ෙྜྷḩŝ✚ᯕ⦽₉ᯕᱱᮥᅕᯕ ḡᦫ۵݅ŁᅕŁ⦹ᩡ݅⦽⠙↽ɝᩑǍᨱ໕ zᮡ
ᇡ₊ᯕᮁ᮹⦹íԏᮡäᮝಽӹ┡ԍ݅❑┡ۥᨱእ⧕
ḡ⎵ܩᦥaᯥ⥭✙ᵝᄡ᳑ḢÕvᨱᮁญ⧉ᮥ
ᅕŁ⦽ᩑǍࠥᯩ۵ߑ ᯕ۵ḡ⎵ܩᦥ᮹ᖙɁส⩶ᖒ ᨱݡ⦽ԏᮡ⊽⪵ࠥᨱʑᯙ⧁äᮝಽᔾbࡽ݅
⢽໕Ñ⋁ʑᨱෙ₉ᯕ
ᖙ aḡ ݅ෙ ❑┡ۥ ⢽໕ TNPPUI BDJEFUDIFE TBOECMBTUFETVSGBDFTᨱᕽ⊹ᮡᔢ⦝ᖙ⡍᮹⟝ḱŝᇡ
₊ᮥእƱ⦽đŝ TNPPUI⢽໕ŝBDJEFUDIFE⢽໕ᨱᕽ
TBOECMBTUFE⢽໕ᅕ݅ᔢ⦝ᖙ⡍᮹ᇡ₊ᯕᯝᨕӹ ۵äᮝಽӹ┡ԍ݅እ⦽đŝಽ QPMJTIFE TBOE
CMBTUFEəญŁQMBTNBTQSBZFE⢽໕ᨱᕽ᮹⊹ᮡᔢ⦝
ᖙ⡍᮹⟝ḱŝᇡ₊ ᷾ᮥእƱ⦹ᩡᮥভQPMJTIFE⢽
໕ᨱᕽ᮹ᔢ⦝ᖙ⡍᮹⟝ḱŝᇡ₊ ᷾ᯕaᰆ⪽ၽ⦹
ᩡŁ QMBTNBTQSBZFE❑┡ۥ⢽໕ᨱᕽaᰆਉᨕḡ۵
đŝෝᅕᩡ݅
⦹ḡอ࠺ྜྷᝅ⨹ᨱᕽ۵ḡݡᵝ᮹Ñ⋁ʑᨱෙ
ᩑ᳑Ḣ ⊹ᮁ᮹ ₉ᯕ۵ ᨧ۵ äᮝಽ ӹ┡ԍ݅
"CSBIBNTTPO॒᮹}ෝᯕᬊ⦽ᩑǍᨱᕽ ᔑᇡ⦽
⢽໕᮹ḡݡᵝ᪡ᩑษࡽ⢽໕᮹ḡݡᵝෝእƱ⦹ᩡᮥ
ভ ḡݡᵝᵝᄡ᮹ᔢ⦝᪡đ⧊᳑Ḣᇡ₊ᨱᕽࢱ᳦ඹ⢽
໕e᮹₉ᯕaᨧ۵äᮝಽӹ┡ԍ݅✚⯩⎽ñᖍᮁ
᮹ᵝ⧪ႊ⨆ᯕÑ⊽⢽໕ᯕӹᩑษࡽ⢽໕༉ࢱᨱᕽᰆ
⇶ᨱ⠪⧪⦽ႊ⨆ᮝಽᵝ⧪⦹۵äᮥšₑ⧁ᙹᯩᨩ݅
ษ₍aḡಽ(MBVTFS॒ᯕၽ⢽⦽ᔍ௭ᮥݡᔢᮝಽ⦽
ᩑǍᨱ໕ᔑ⪵ࡽ❑┡ۥ⢽໕ ᔑᇡ❑┡ۥ⢽
໕ ᩑษࡽ❑┡ۥ⢽໕bb᮹ᯥ⥭✙ᵝᄡᔾྜྷ⦺ᱢ
⡎Ğᮥ᳑ᔍ⦹ᩡᮥভ ᱥℕʙᯕ۵_NNಽᮁ᮹
⦽₉ᯕaᨧᨩ݅
Review Article
ᯝၹᱢᮝಽḡݡᵝ᮹⢽໕Ñ⋁ʑaÑ⋁ᙹಾᖙɁส ᮹⩶ᖒࠥฯᯕ⇶ᱢࡹӹⱡNᯕ⦹᮹ၙᖙÑ⋁ʑ ۵ᖙɁส⩶ᖒᨱᵲݡ⦽ᩢ⨆ᮥᵝḡᦫᮭᯕᅕŁࡽၵ
ᯩ݅ ⦹ḡอ3JNPOEJOJ॒ᮡON᪡ON᮹ၙ
ᖙÑ⋁ʑෝaḥࢱ⢽໕ᮥእƱ⦹ᩡᮥভ ONᨱᕽ
ᱢᮡᖙɁสᯕ⩶ᖒࢉᮥၽč⦹ᩡ݅ੱ⦽↽ɝᩑǍ ᨱᕽ ONᯕ⦹᮹ၙᖙÑ⋁ʑෝaḥ⢽໕ᨱᕽ⢽໕
Ñ⋁ʑ᪡ᖙɁส⩶ᖒᮡ᧲᮹ᔢššĥෝᅕᩡ݅
⢽໕ᱷᮭᖒᨱෙ₉ᯕ
⢽໕᮹ᱷᮭᖒᮡ݉႒ḩ᮹⯂₊ᐱᦥܩᖙ⡍᮹ᇡ₊
ᨱࠥᵲ⦽ᩎ⧁ᮥ⧁ᙹᯩ݅ᱷᮭᖒᮡ⢽໕ŝᧂℕ
e᮹ࠥᨱᕽࠥᔍᯕಽ⊂ᱶࡹ۵ᱲⅪbᨱ᮹⧕ᙹ ప⪵ࡽ݅ᱲⅪbᯕࠥᅕ᯲݅ᮥভ⊽ᙹᖒᯕ⦹
໑ ࠥᨱɝᱲ⦹໕Ⅹ⊽ᙹᖒᯕ⧁ᙹᯩ݅ᱲⅪbᯕ
ࠥෝⅩŝ⦹໕ᗭᙹᖒᯕ໑ ࠥᯕᔢᯕ໕Ⅹᗭᙹᖒ ᯕ⦽݅⢽໕᮹ᱷᮭᖒᯕၙ⊹۵ᔾྜྷ⦺ᱢᩢ⨆ᮡ
݉႒ḩŝzᮡⓑᇥᯱ᮹⢽໕⯂₊ ᩑ᳑ḢŝĞ᳑Ḣ ᖙ⡍᮹⢽໕ŝ᮹ᔢ⪙᯲ᬊ ᖙɁᇡ₊ၰၵᯕ᪅⦥
ᔾᖒ ᯥᔢᨱᕽʼnᮖ⧊᮹ᱶࠥᯕ݅ੱ⦽ᱷᮭᖒ᮹
᷾a۵ᖍᮁ༉ᖙ⡍᮹ᇡ₊ŝ⟝ḱᖒᨱᩢ⨆ᮥၙ⊽݅
⎵ၽ✙Ⓧ್༑ญቭߕᯥ⥭✙ෝᯕᬊ⦽ᩑǍᨱᕽ ⢽
໕᮹ℎđᖒŝᱷᮭᖒᯕᖍᮁ༉ᖙ⡍᮹ᱱ₊᮹᷾ḥŝš ĥaᯩᨩ݅4DIXBS[॒᮹}ෝᯕᬊ⦽ᩑǍᨱᕽ⪵
⦺ᱢᄡ⩶ᮝಽ⊽ᙹᖒᮥ᷾a┉TBOECMBTUFEMBSHF
HSJU BDJEFUDIFE 4-"ᯥ⥭✙᪡ᱥ☖ᱢᯙႊ᮹
4-"ᯥ⥭✙ෝพ⦹ᩍእƱ⦽đŝ⢽໕᮹⊽ᙹᖒᯕ
ᩑ᳑Ḣđ⧊ᨱᩢ⨆ᮥၙ⋉ᮥᅕŁ⦹ᩡ݅ᯕᩑǍᨱᕽ
พ⬥Ⅹʑ_ᯝᨱᕽ⪵⦺ᱢᮝಽᄡ⩶┉4-"ᯥ⥭
✙ᨱᕽᯙᱲ⊹᳑ʼnಽᇡ░ᔩಽᬕ⩩š᮹ᔾᖒᯕ
ⅪḥࡹᨩŁᯕᨱDPMMBHFOSJDIQSPWJTJPOBMDPO
OFDUJWFUJTTVFNBUSJY᮹ᔾᖒੱ⦽Ⅺḥࡹᨩ݅
ḡݡᵝ᮹ॵᯱᯙᨱෙ₉ᯕ
,JN॒ᮡ}ෝᯕᬊ⦽ᩑǍᨱᕽDPODBWFNJDSP
HSPPWFEQSPGJMFT DPOWFYNBDIJOFEQSPGJMFT əญŁ
TUSBJHIUBOPEJDBMMZPYJEJ[FEQSPGJMFTᖙaḡḡݡᵝॵ
ᯱᯙ᮹ᯥ⥭✙ෝพ⦹ᩍᩑ᳑ḢŝĞ᳑Ḣ᮹⊹ᮁෝ
እƱ⦹ᩡ݅᳑Ḣ⦺ᱢᇥᕾđŝ DPOWFYNBDIJOFE
QSPGJMFᨱᕽᔢ⦝ᖙ⡍᮹ᇡ₊ʙᯕaaᰆʙᨩŁ DPO
DBWFNJDSPHSPPWFEQSPGJMFᨱᕽđ⧊᳑Ḣᇡ₊᮹ʙᯕa
aᰆʙŁʼn⯂ᙹaaᰆᱢᨩ݅ੱ݅ෙ࠺ྜྷᩑǍᨱ ᕽษ₍aḡಽDPODBWFNJDSPHSPPWFE⩶┽᮹ḡݡᵝa
ᯥ⥭✙ᵝ᭥ᩑ᳑Ḣ᮹ᮁḡᨱɮᱶᱢᮝಽ᯲ᬊ⦽݅Ł
ᅕŁ⦹ᩡ݅
$IFISPVEJ॒ᮡUJUBOJVNDPBUFEFQPYZJNQMBOUᨱᙹ
⠪ႊ⨆ᮝಽ7ᯱ⩶┽᮹HSPPWFෝⱡNʫᯕಽ⩶ᖒ⬥
ᶱ᮹Ǎ}⊂ᨱพ ݡ᳑Ǒᯙᩑษࡽ⢽໕᮹ᯥ⥭✙
᪡ᩑ᳑Ḣᇡ₊ᨱݡ⧕እƱ⦹ᩡ݅ᩑǍđŝHSPPWFa
⩶ᖒࡽᯥ⥭✙ᨱᕽᩑษࡽ⢽໕᮹ᯥ⥭✙ᅕ݅Ṉ
ᮡᔢ⦝ᇡ₊ŝʕđ⧊᳑Ḣᇡ₊ᯕšₑࡹᨩᮝ໑
ᱢᮡ♕⇶ᮥᅕᩡ݅zᮡᱡᯱ᮹݅ෙᩑǍᨱᕽUJUBOJ
VNDPBUFEJNQMBOUᨱHSPPWFෝbbᙹḢႊ⨆ŝ ᙹ⠪
ႊ⨆ᮝಽ⩶ᖒ⦹ᩍᩑษࡽ⢽໕᮹ݡ᳑Ǒŝᩑ᳑Ḣᇡ₊
ᮥእƱ⦹ᩡ݅đŝ۵ᙹḢႊ⨆᮹HSPPWFෝ⩶ᖒ⦽
ᯥ⥭✙ᨱᕽ۵ᔢ⦝᮹⦹ႊ᷾ᯕݡ᳑Ǒᅕ݅Ⅺḥࡹ
ᨩŁ ᙹ⠪ႊ⨆᮹HSPPWFෝ⩶ᖒ⦽ᯥ⥭✙ᨱᕽ۵ᔢ
⦝᮹⦹ႊ᷾ᯕႊḡࡹᨩ݅ᯕ్⦽ᩑǍđŝॅᮡᙹ
⠪ႊ⨆᮹HSPPWFaᔢ⦝᮹⦹ႊ᷾ᮥႊḡ⧁ᙹᯩᮭ
ᮥஜ⦽݅
ᦥᬙ్/FWJOT॒ ᮡ࠺ྜྷᝅ⨹ၰᯥᔢᝅ⨹ᨱᕽᯥ⥭
✙ Ğᇡᨱ ౩ᯕᱡෝ ᔍᬊ⦹ᩍ _ ⱡN Ⓧʑ᮹
NJDSPHSPPWFෝ⩶ᖒ⦽अ᳑Ḣ⦺ᱢ ႊᔍᖁ⦺ᱢᮝಽᇥ ᕾ⦽đŝ đ⧊᳑ḢԕƱᬱᖍᮁ᮹ᙹḢᱢᵝ⧪ŝ⧉̹
ᄡᩑʼn⯂ᙹపᯕqᗭ⦹۵äᮥšₑ⦹ᩡ݅*HMIBVU॒
ᮡ❑┡ۥ⢽໕ᨱ⩶ᖒ⦽NJDSPHSPPWF᮹մᯕᨱෙᩑ
ᯥ⥭✙᮹Ǎ᳑ᨱෙ₉ᯕ
ᯝℕ⩶ᯥ⥭✙۵ᱱสš☖ᇡaᯥ⥭✙᮹ᯝᇡᯕ အಽእ⋉⦹ႊᮝಽพ⦹íࡹ໑ ᇥญ⩶ᯥ⥭✙
۵ᱱสš☖ᇡᯙḡݡᵝaᯥ⥭✙Łᱶℕ᪡ᇥญaa
܆⦹Ł ⋉⦹ እ⋉⦹ႊ༉ࢱพa܆⦹݅}ෝᯕ ᬊ⦽ᩑǍᨱᕽ⋉⦹ እ⋉⦹ႊᮝಽพ⦽ᯥ⥭✙
ᵝᄡ᮹ᩑ᳑ḢḢĞŝʼn᳑ḢᮥእƱ⦹ᩡᮥভ ᮁ᮹⦽
₉ᯕaᨧ۵äᮝಽӹ┡ԍ݅ੱ⦽ᔍ௭ᮥݡᔢᮝಽ
⦽ᩑǍᨱᕽࠥ ֥ᯕᔢᰆʑešₑđŝ⋉⦹ እ⋉⦹
ႊeᨱᄡᩑʼn⯂ᙹపᨱᯩᨕᮁ᮹⦽₉ᯕaᨧ۵ä ᮝಽӹ┡ԍ݅
࠺ྜྷᝅ⨹ᨱᕽᯝℕ⩶ᯥ⥭✙᪡ᇥญ⩶ᯥ⥭✙e ᮹ᩑ᳑Ḣ⊹ᮁෝእƱ⦽ᩑǍa⪽ၽ⦹íᯕᨕᲙ᪵۵ ߑ ᩑǍᯱeđŝa݅᧲⦹íӹ┡ԍ݅ᯝℕ⩶ᯥ⥭
✙᪡ᇥญ⩶ᯥ⥭✙eᯥ⥭✙ᵝᄡᩑ᳑ḢᮥእƱ⦹
ᩡᮥভ ᱲ⧊ᔢ⦝᪡đ⧊᳑Ḣ᮹ḢĞᯕᮁᔍ⦹ᩡ݅
ᩑ᳑Ḣđ⧊ᯕᯝᨕӹ۵Ŕࠥᕽಽእ⦹ᩡ۵ߑ ᯝℕ
⩶ᯥ⥭✙ᨱᕽ۵ᯥ⥭✙᮹⠪⪽໕༊ᇡ᭥ ᇥญ⩶
ᯥ⥭✙ᨱᕽ۵ḡݡᵝᙹᵡᨱᕽđ⧊ᯕᯕᨕᲭ݅
⦽⠙)FSNBOO॒ᨱ໕ ᯝℕ⩶ᯥ⥭✙ᨱᕽ⊹
ᮡᄡᩑᯕ⊹š⊂ᮝಽ᭥⊹⦹ᩡᮝ໑ ᔾྜྷ⦺ᱢ⡎Ğ ᯕᯱᩑ⊹᪡ᮁᔍ⦹݅ŁᅕŁ⦹ᩡ݅ᇥญ⩶ᯥ⥭
✙ᨱᕽ۵ḡݡᵝ᪡ᯥ⥭✙ĥ໕ᇡɝᨱᕽᩝ᷾ᖙ⡍⋉
ᮅᯕၽčࡹᨩ݅ᯕ۵ᩑ᳑Ḣđ⧊ᮥᗱᔢ┅ḡᦫ۵
äᮝಽӹ┡ԍᮝ໑ ᇥญ⩶ᯥ⥭✙ᨱᕽ۵FYUFSOBM JOUFSOBMUZQF༉ࢱᨱᕽၽčࡹᨩᮝӹ ᯝℕ⩶ᯥ⥭✙
ᨱᕽ۵ၽčࡹḡᦫᦹ݅ ᯕ్⦽ᱽ⦽ࡽჵ᭥᮹ᖙ⡍
⋉ᮅᮡ݅ప᮹ʼnᗭᝅŝ۵ᩑšࡹḡᦫ۵äᮝಽӹ┡ԍ
*** 고찰 및 결론
ᯕᔢ᮹ᩑǍෝ☖⦹ᩍ⊹ᦥ᪡ᯥ⥭✙ᵝ᭥᳑Ḣ᮹
₉ᯕ᪡ᯥ⥭✙ḡݡᵝ⢽໕᮹✚ᖒᨱෙᩑ᳑Ḣ⊹
ᮁ᮹₉ᯕෝŁₑ⦹ᩡᮝ໑ ݅ᮭŝzᮡđುᮥࠥ⇽⦹
ᩡ݅ᯥ⥭✙ᵝ᭥ᩑ᳑Ḣᮡ⊹ᮁŝᱶᨱᕽḡݡᵝ᮹
݅᧲⦽ྜྷḩᱢ✚ᖒᨱ᮹⧕ᩢ⨆ᮥၼᮝ໑ ᯕෝ☖⧕ᔢ
⦝᮹⦹ႊ᷾ŝᯕᵝෝḡᩑ┅Łđ⧊᳑Ḣ᮹ᇡ₊ᮥ
ᮁࠥ⦹ᩍᅕ݅ᦩᱶᱢᯙᩑ᳑Ḣၡ⠱ෝᯕᙹᯩ݅
ᯥ⥭✙ᵝ᭥ᩑ᳑Ḣᮡ⊹ᮡŝǍ᳑ᱢᮝಽᮁᔍ⦹
ӹ⠪Ɂᔾྜྷ⦺ᱢ⡎Ğᮡᯥ⥭✙ᨱᕽⓍ݅đ⧊᳑
Ḣᇡ₊ᮡ⊹ᦥᨱእ⧕ᳬḡᦫᮡʑĥᱢᱡ⧎ᮥaḡ Łᯩᮝ໑ ⩩šᙹ᮹qᗭಽᯥ⥭✙ᵝ᭥ᩑ᳑Ḣ᮹໕ ᩎၹ᮲ᯕᔢݡᱢᮝಽԏᮥᙹᯩ݅
❑┡ۥḡݡᵝaᯥ⥭✙ᵝ᭥ᩑ᳑Ḣ⊹ᮁᨱaᰆ
ᳬᮡᔾℕᱢ⧊ᖒᮥaḡ໑ ᖙၚᯕӹḡ⎵ܩᦥḡݡ ᵝࠥᩑǍᨱᕽᳬᮡđŝෝᅕᩡ݅⦹ḡอ⊹ŝᬊ
⡍ᖙฑᯕӹɩ⧊ɩᮡ࠺ྜྷᝅ⨹ᨱᕽᔾℕᱢ⧊ᖒᯕਉ ᨕḡ۵äᮝಽӹ┡ԍ݅
ᖙ⡍ᝅ⨹ᨱᕽḡݡᵝ⢽໕Ñ⋁ʑa᷾a⧉ᨱ
ᔢ⦝᷾ၰᇡ₊ᯕᨖᱽࡹ۵⬉ŝaᯩᨩᮝӹ ࠺ྜྷᝅ
⨹ၰᯥᔢᝅ⨹ᨱᕽ۵ə⬉ŝa⪶ᝅ⯩ӹ┡ӹḡᦫᦹ
݅
࠺ྜྷᝅ⨹ᨱᕽḡݡᵝ⢽໕᮹⊽ᙹᖒᯕ᷾a⧉ᨱ
ᩑ᳑Ḣᇡ₊ᯕⅪḥࡹᨩ݅
࠺ྜྷᝅ⨹ᨱᕽDPODBWF⩶┽᮹ḡݡᵝaᩑ᳑Ḣ᮹
ᦩᱶᱢᯙᮁḡᨱʑᩍ⦹ᩡŁ ᱢᱩ⦽Ⓧʑ᪡⩶┽᮹
Review Article
NJDSPHSPPWF᮹᳕ᰍ۵đ⧊᳑Ḣᇡ₊ᮥ᷾ḥ⦹Łᔢ⦝
⦹ႊᯕᵝෝᨖᱽ⧁ᙹᯩ݅
ᯥ⥭✙พႊᨱෙᩑ᳑Ḣ⊹ᮁ᮹₉ᯕ۵
ᨧᨩᮝ໑ ᯥ⥭✙Ǎ᳑ᨱෙᩑ᳑Ḣ⊹ᮁ᮹₉ᯕ۵
ᩑǍᯱeᔢၹࡽđŝෝᅕᩡ݅
References
1. Berglundh T, Lindhe J, Ericsson I, et al. The soft tissue barrier at implants and teeth. Clin Oral Implants Res. 1991; 2: 81-90.
2. James RA, Schultz RL. Hemidesmosomes and the adhesion of junctional epithelial cells to metal implants--a preliminary report. Oral Implantol. 1974; 4: 294-302.
3. Listgarten MA. Soft and hard tissue response to endosseous dental implants. Anat Rec. 1996; 245: 410-425.
4. Rompen E, Domken O, Degidi M, et al. The effect of material characteristics, of surface topography and of implant components and connections on soft tissue integration: a literature review. Clin Oral Implants Res. 2006; 17(Suppl 2): 55-67.
5. Nevins M, Kim DM, Jun SH, et al. Histologic evidence of a connective tissue attachment to laser microgrooved abutments: a canine study. Int J Periodontics Restorative Dent. 2010; 30: 245-255.
6. Gargiulo AW, Wentz FM, Orban B. Dimensions and relations of the dentogingival junction in humans. J Periodontol. 1961; 32: 261-267.
7. Stern IB. Current concepts of the dentogingival junction: the epithelial and connective tissue attachments to the tooth. J Periodontol. 1981; 52:
465-476.
8. Moon IS, Berglundh T, Abrahamsson I, et al. The barrier between the keratinized mucosa and the dental implant. An experimental study in the dog. J Clin Periodontol. 1999; 26: 658-663.
9. Hermann JS, Buser D, Schenk RK, et al. Biologic Width around one- and two-piece titanium implants. Clin Oral Implants Res. 2001; 12: 559-571.
10. Berglundh T, Lindhe J, Jonsson K, et al. The topography of the vascular systems in the periodontal and peri-implant tissues in the dog. J Clin Periodontol. 1994; 21: 189-193.
11. Buser D, Weber HP, Donath K, et al. Soft tissue reactions to non- submerged unloaded titanium implants in beagle dogs. J Periodontol.
1992; 63: 225-235.
12. Ericsson I, Lindhe J. Probing depth at implants and teeth. An experimental study in the dog. J Clin Periodontol. 1993; 20: 623-627.
13. Lang NP, Wetzel AC, Stich H, et al. Histologic probe penetration in healthy and inflamed peri-implant tissues. Clin Oral Implants Res. 1994;
5: 191-201.
14. Chang M, Wennström JL, Odman P, et al. Implant supported single- tooth replacements compared to contralateral natural teeth. Crown and soft tissue dimensions. Clin Oral Implants Res. 1999; 10: 185-194.
15. Brägger U, Bürgin WB, Hämmerle CH, et al. Associations between clinical parameters assessed around implants and teeth. Clin Oral Implants Res. 1997; 8: 412-421.
16. Mombelli A, Mühle T, Brägger U, et al. Comparison of periodontal and peri-implant probing by depth-force pattern analysis. Clin Oral Implants Res. 1997; 8: 448-454.
17. Etter TH, Håkanson I, Lang NP, et al. Healing after standardized clinical probing of the perlimplant soft tissue seal: a histomorphometric study in dogs. Clin Oral Implants Res. 2002; 13: 571-580.
18. Schwarz F, Mihatovic I, Ferrari D, et al. Influence of frequent clinical probing during the healing phase on healthy peri-implant soft tissue formed at different titanium implant surfaces: a histomorphometrical study in dogs. J Clin Periodontol. 2010; 37: 551-562.
19. Lindhe J, Berglundh T. The interface between the mucosa and the implant. Periodontol 2000. 1998; 17: 47-54.
20. Abrahamsson I, Berglundh T, Glantz PO, et al. The mucosal attachment at different abutments. An experimental study in dogs. J Clin Periodontol. 1998; 25: 721-727.
21. Räisänen L, Könönen M, Juhanoja J, et al. Expression of cell adhesion complexes in epithelial cells seeded on biomaterial surfaces. J Biomed Mater Res. 2000; 49: 79-87.
22. Kohal RJ, Weng D, Bächle M, et al. Loaded custom-made zirconia and titanium implants show similar osseointegration: an animal experiment.
J Periodontol. 2004; 75: 1262-1268.
23. Vigolo P, Fonzi F, Majzoub Z, et al. Evaluation of gold-machined UCLA-type abutments and CAD/CAM titanium abutments with hexagonal external connection and with internal connection. Int J Oral Maxillofac Implants. 2008; 23: 247-252.
24. Linkevicius T, Apse P. Influence of abutment material on stability of peri-implant tissues: a systematic review. Int J Oral Maxillofac Implants.
2008; 23: 449-456.
25. Nothdurft FP, Fontana D, Ruppenthal S, et al. Differential behavior of fibroblasts and epithelial cells on structured implant abutment materials:
27. Degidi M, Artese L, Scarano A, et al. Inflammatory infiltrate, microvessel density, nitric oxide synthase expression, vascular endothelial growth factor expression, and proliferative activity in peri- implant soft tissues around titanium and zirconium oxide healing caps. J Periodontol. 2006; 77: 73-80.
28. Schou S, Holmstrup P, Hjørting-Hansen E, et al. Plaque-induced marginal tissue reactions of osseointegrated oral implants: a review of the literature. Clin Oral Implants Res. 1992; 3: 149-161.
29. Hormia M, Könönen M, Kivilahti J, et al. Immunolocalization of proteins specific for adhaerens junctions in human gingival epithelial cells grown on differently processed titanium surfaces. J Periodontal Res. 1991; 26: 491-497.
30. Lauer G, Wiedmann-Al-Ahmad M, Otten JE, et al. The titanium surface texture effects adherence and growth of human gingival keratinocytes and human maxillar osteoblast-like cells in vitro. Biomaterials. 2001;
22: 2799-2809.
31. Abrahamsson I, Zitzmann NU, Berglundh T, et al. The mucosal attachment to titanium implants with different surface characteristics: an experimental study in dogs. J Clin Periodontol. 2002; 29: 448-455.
32. Glauser R, Schüpbach P, Gottlow J, et al. Periimplant soft tissue barrier at experimental one-piece mini-implants with different surface topography in humans: a light-microscopic overview and histometric analysis. Clin Implant Dent Relat Res. 2005; 7(Suppl 1): S44-S51.
33. Bollen CM, Papaioanno W, Van Eldere J, et al. The influence of abutment surface roughness on plaque accumulation and peri-implant mucositis. Clin Oral Implants Res. 1996; 7: 201-211.
34. Bürgers R, Gerlach T, Hahnel S, et al. In vivo and in vitro biofilm formation on two different titanium implant surfaces. Clin Oral Implants Res. 2010; 21: 156-164.
35. Rimondini L, Farè S, Brambilla E, et al. The effect of surface roughness on early in vivo plaque colonization on titanium. J Periodontol. 1997;
68: 556-562.
36. Xing R, Lyngstadaas SP, Ellingsen JE, et al. The influence of surface nanoroughness, texture and chemistry of TiZr implant abutment on oral biofilm accumulation. Clin Oral Implants Res. 2015; 26: 649-656.
37. Gittens RA, Scheideler L, Rupp F, et al. A review on the wettability of dental implant surfaces II: biological and clinical aspects. Acta Biomater.
bioadhesive outcomes: methods and results. J Biomed Mater Res. 1984;
18: 337-355.
40. Schwarz F, Ferrari D, Herten M, et al. Effects of surface hydrophilicity and microtopography on early stages of soft and hard tissue integration at non-submerged titanium implants: an immunohistochemical study in dogs. J Periodontol. 2007; 78: 2171-2184.
41. Kim S, Oh KC, Han DH, et al. Influence of transmucosal designs of three one-piece implant systems on early tissue responses: a histometric study in beagle dogs. Int J Oral Maxillofac Implants. 2010; 25: 309-314.
42. Iglhaut G, Becker K, Golubovic V, et al. The impact of dis-/reconnection of laser microgrooved and machined implant abutments on soft- and hard-tissue healing. Clin Oral Implants Res. 2013; 24: 391-397.
43. Chehroudi B, Gould TR, Brunette DM. Effects of a grooved titanium- coated implant surface on epithelial cell behavior in vitro and in vivo. J Biomed Mater Res. 1989; 23: 1067-1085.
44. Chehroudi B, Gould TR, Brunette DM. Titanium-coated micromachined grooves of different dimensions affect epithelial and connective-tissue cells differently in vivo. J Biomed Mater Res. 1990;
24: 1203-1219.
45. Nevins M, Camelo M, Nevins ML, et al. Connective tissue attachment to laser-microgrooved abutments: a human histologic case report. Int J Periodontics Restorative Dent. 2012; 32: 385-392.
46. Abrahamsson I, Berglundh T, Moon IS, et al. Peri-implant tissues at submerged and non-submerged titanium implants. J Clin Periodontol.
1999; 26: 600-607.
47. Petersson A, Rangert B, Randow K, et al. Marginal bone resorption at different treatment concepts using Brånemark dental implants in anterior mandibles. Clin Implant Dent Relat Res. 2001; 3: 142-147.
48. Abrahamsson I, Berglundh T, Wennström J, et al. The peri-implant hard and soft tissues at different implant systems. A comparative study in the dog. Clin Oral Implants Res. 1996; 7: 212-219.
49. Ericsson I, Persson LG, Berglundh T, et al. Different types of inflammatory reactions in peri-implant soft tissues. J Clin Periodontol.
1995; 22: 255-261.
50. Dibart S, Warbington M, Su MF, et al. In vitro evaluation of the implant- abutment bacterial seal: the locking taper system. Int J Oral Maxillofac Implants. 2005; 20: 732-737.
