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A Case of Gabapentin-induced Myoclonus in a Type 2 Diabetic Patient with End-stage Renal Disease

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￭ S-348 ￭

A Case of Gabapentin-induced Myoclonus in a Type 2 Diabetic Patient with End-stage Renal Disease

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

*Eun Yeong Choe, Byung-Wan Lee

Development of myoclonus can be manifestated as a side effect of antiepileptic drugs in subjects with preexisting epilepsy, post-traumatic brain injury, encephalopathy, and focal and multifocal brain lesions. A 69-year-old male showed newly onset severe myoclonus and confusion 2 days after taking 1200 mg of gabapentin. He had end-stage renal disease secondary to type 2 diabetes and was on hemodialysis twice a week. After increasing hemodialyis 3 times a week and discontinuing gabapentin, myoclonus spontaneously resolved. Here we first report a case of myoclonus in a Korean subject with diabetic renal failure. We recommend that administration of gabapentin for diabetic subjects with renal disease should be cautious.

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