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￭ S-417 ￭
Association between body weight changes and menstrual irregularity
1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, 2Department of Medical Statistics, College of Medicine, The Catholic University of Korea, Seoul, Korea, 3Department of Obstetrics and Gynecology, College of Medicine, The Catholic University
of Korea, Seoul, Korea, 4Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, Seoul, Korea
*Kyung Min Ko1, Kyungdo Han2, Yong Gyu Park2, Youn Jee Chung3, Seung-Hwan Lee1,4
Objective: Menstrual irregularity is an indicator of endocrine disorders and reproductive health status. It associated with various diseases and medical conditions, including obesity and underweight. We aimed to assess the association between body weight changes and menstrual irregularity in Korean women. Study design: A total of 4621 women 19-54 years of age who participated in the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES) were included in this study. Self-reported questionnaires were used to collect medical information assessing menstrual health sta- tus and body weight changes. Main outcome measures: Odds ratios (ORs) and 95% CI were calculated to evaluate the association between body weight changes and menstrual irregularity. Results: Significantly higher ORs (95% CI) were observed in the association between menstrual irregularity and both weight loss (1.59 [1.14, 2.22]) and weight gain (1.53 [1.22, 1.93]) after adjusting for age, current smoking, heavy alcohol drinking, regular ex- ercise, education, income, metabolic syndrome, age of menarche, parity and stress perception. Of note, significant associations were only observed in subjects with obesity and abdominal obesity, but not in non-obese or non-abdominally obese subjects. U-shaped patterns were demonstrated in both obese and abdominally obese subjects, indicating that greater changes in body weight are associated with higher odds of menstrual irregularity.
Conclusions: We found a U-shaped pattern of association between body weight changes and menstrual irregularity among obese women in the general Korean population. This result indicates that not only proper weight management but also changes in body weight may influence the regulation of the menstrual cycle.
￭ S-418 ￭
High serum calcium were independently associated with a decreased risk of incident diabetes
Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea
*Kye Hwa Jung, Ji Cheol Bae
Short title: Serum calcium level and diabetes risk Introduction: Extracellular calcium is required for the secretion of insulin in response to elevated glucose level. It has been reported that the serum calcium concentration is positively correlated with blood glucose level. We assessed the risk of in- cident diabetes in association with calcium level in non-diabetic subjects. Materials and Methods: A retrospective longitudinal analysis of subjects who had participated in comprehensive health check-ups at least 4 times over a 7-year period (between 2006 and 2012) was conducted. A total of 23,121 subjects were categorized into tertiles based on baseline corrected calcium level. We evaluated the cross-sectional correlation between serum calcium and blood glucose level and then compared the development of diabetes among corrected calcium tertiles during the follow-up period. Results:
During a mean follow-up of 54.7±14.7 months, 1,929 (8.3%) new cases of diabetes occurred. The serum corrected calcium level was positively corre- lated with HbA1c and fasting plasma glucose level at baseline. As the corrected calcium category increased at baseline, the percentage of subjects who developed diabetes increased during the follow-up period (Chi-square test for linear trend, p＝0.047). However, after adjusting for multiple variables, including baseline fasting glucose, HbA1c, and BMI, the risk for incident diabetes decreased as corrected calcium tertile increased, with hazard ratios of 0.85 (95% CI 0.76-0.94) and 0.70 (95% CI 0.63-0.79) compared with the lowest calcium tertile. Conclusions: In non-diabetic Korean individuals, higher level of serum calcium was associated with a lower risk of incident diabetes, independent of baseline glycemic status and obesity.
