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=Abstract =
Expression of Sialosyl-Tn Antigen in Breast Cancer &
Its Correlation with Prognostic Parameters
Yong~TaeKwon, SeMHeon Cha, Young-Hoon Kim, Sang-Soon Kim, Sook-Hee Hong', Jung-Man Kim' and Seok-Reyol Choi3
Departments of General Surgery, Patholog/, Clinical Patho[ogl and Internal Medicini, Dong-A University College of Medicine
To detennine whether the expression of Sialosyl-Tn antigen may have its putative relationship as an established or potentially useful clinicopathologic prognostic parameter in breast cancer, we evaluated 110 patients with invasive breast carcinoma, using fonnalin-fixed, paraffin-embedded tissue sections. STu antigen was detected by the HB-STn antibody using an avidin-biotin- peroxidase method. The parameters studied were tumor size, nodal status, stage, histologic grade, ER/PR expression, DNA ploidy and S-phase fraction. STn expression was observed in 42 patients (38.2%) with breast cancer. The expression rate of STn was associated with axillary node metastasis. A tendency towards an association between STn expression and tumor size or TNM stage. There was no relationship between STu expression and histologic grade, ER/PR expression, DNA ploidy and S-phase fraction. We conclude that the detection of STu expression may be useful for predicting lymph node metastasis. (Korean J of Breast Cancer 1998;1:208...214) Key Words: Sialosyl-Tn, Breast cancer, Prognostic factors
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