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5 -Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity

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Figure 1. SELEX-based RIG-I aptamer screening. (A) Schematic diagram depicting the RIG-I specific RNA aptamer screening process
Figure 3. RIG-I aptamer activates signaling pathways for IFNb produciton. (A) Nuclear translocation of IRF3 by RIG-I aptamer
Figure 6. Post-treatment of CL9 blocks viral replication. (A) Experimental scheme: HepG2 cells were infected with virus for 3 h before aptamer (75 pmol) treatment and incubated for an additional 3 or 9 h before the assay
Figure 7. Pre-treatment of CL9 inhibited viral replication. (A) Experimental scheme: Prior to virus infection, HepG2 cells were pre-treated with 75 pmol of aptamers for 6 h

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