몸의 다양한 칼슘 풀 중 모발 칼슘과 골밀도는 음의 상관관계가 있었으 나, 관상동맥 칼슘 점수는 모발 칼슘 및 골밀도와 유의미한 상관관계가 없었다.
여성의 경우 관상동맥 칼슘 점수는 모발 칼슘 및 골밀도와 유의미한 음의 상관 관계가 있었다. 모발 미네랄 검사를 통한 모발 칼슘의 측정은 몸의 칼슘 대사를 확인하는 유용한 지표가 될 수 있을 것으로 생각되며, 앞으로 인체의 칼슘 대사 와 관련된 다양한 요소들, 즉 호르몬, 골대사 지표, 소변 내 칼슘 및 크레아티닌 과 같은 것들을 고려한 대규모 임상 연구가 필요할 것으로 생각된다. 이를 통해, 골다공증과 동맥 경화 같은 만성 질환의 예방과 치료에 큰 도움을 줄 수 있을 것으로 기대된다.
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- 29 - - ABSTRACT -
Low Bone Mineral Density is not related with High Coronary Artery Calcium Score but with High Hair Calcium: The Relationship
among different Calcium Pools in Body
Sang-Hoon Lee
Department of Medical Sciences The Graduate School, Ajou University
(Supervised by Associate Professor Bom-Taeck Kim)
Background: With aging, calcium efflux from bone increased as age-related bone loss reduces bone mineral density and age-related calcium adoption in arterial wall progressively stiffens blood vessels, insinuating calcium exchange among different calcium pools in body however these relationships have not been elucidated yet. We investigated calcium transport among different calcium pools in body, by pursuing associations among calcium intake and excretion, serum, hair, bone and blood vessels.
Methods: Current study was a retrospective observational study. We examined 228 adults who visited Ajou University Hospital Health Promotion Center, Korea for regular health check-up. We measured Agatston coronary artery calcium score(CACS) by coronary multidetector computed tomography, bone mineral density(BMD) by dual energy X-ray absorptiometry, and hair calcium concentration by TEI (Trace Elements Inc.) at USA.
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Results: The mean age of study subjects was 50 ± 7 years (32-75 years), and male subjects composed 72.5%. The mean value of CACS was 12.3 ± 63.97. Among the subjects, 153 subjects (84.1%) showed no coronary artery calcium deposits. In correlation analysis, BMD was not related with CACS, but negatively related with hair calcium level in total femur BMD (r = -0.146, P = 0.049). In addition to, BMDs was significantly correlated with serum creatinine (r = 0.258, P < 0.001 with L1-4 and r = 0.312, P < 0.001 with femur total). CACS also positively correlated with serum creatinine (r = 0.161, P = 0.030), but not associated with hair calcium level. Dietary calcium intake had no relationship with other variables. With aging, CACS was increased (r = 0.258, P < 0.001), but serum calcium level (r = -0.224, P = 0.002) and femoral BMDs (r = -0.283, P < 0.001 with neck, r = -0.176, P = 0.018 with total) were decreased.
Conclusions: In body calcium pools, BMD was not related with CACS, but has negative correlation with hair calcium level. To research relationship between osteoporosis and cardiovascular risk with aging, dynamics of different body pools should be taken into account.
Key words: Body calcium pools, Calcium metabolism, Coronary artery calcium score, Bone
mineral density, Hair calcium, Serum calcium, Serum creatinine, Dietary calcium