[PDF] Top 20 The role of IFITM1 in malignant progression of neurofibromas in NF1
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The role of IFITM1 in malignant progression of neurofibromas in NF1
... ３９ 인터페론-감마에 의해 유도된 IFITM1의 발현량 증가는 MPNST 세포의 Ras/Raf/Mek/Erk 경로의 활성화 억제에 영향을 미치는 것을 알 수 있다. IFITM1에 관한 본 연구의 결과가 향후 NF1 악성화 원인규명 및 치료제 개발에 기여할 수 있기를 기대한다. ... See full document
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The role of Bosniak classification in malignant tumor diagnosis: A single institution experience
... variety of helical and conventional CT scanners, and bias of imaging analysis by various ...element of selection bias due to the inclusion of only surgically excised cystic ...criteria ... See full document
6
Immunohistochemical study on the expression of matrix metalloproteinase 2 and high-risk human papilloma virus in the malignant progression of papillomas
... Nevertheless, the expression level of MMP-2 significantly increased as pre-cancerous lesions becoming malignant le- sion and infection rate of HPV almost ...Concerning the study ... See full document
7
Superficial malignant peripheral nerve sheath tumor from recurrent neurofibroma in the abdominal wall of a patient without neurofibromatosis type 1
... advancements in immunochemistry and molecular biology of sarcoma, diagnosis of MPNST remains difficult ...negative in high- grade MPNST [14]. S100 protein is weakly positive in 50% ... See full document
4
Identifying the role of ornithine decarboxylase1 (ODC1) in breast cancer
... Overexpression of ODC1 has been shown to contribute to the formation of tumors in mouse ...is the best-known polyamine biosynthesis inhibitor. The L-enantiomer of DFMO ... See full document
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Functional study of the IFITM1 gene related to tumor progression of NF1
... 현재까지 NF1 에 대한 근본적인 치료법이 없으며, 방사선 요법, 외과적 수술 절제 등의 대증요법만이 알려져 있지만, 근본적인 치료가 되지 않아 재발의 위험성 높다. 또한 이러한 대증요법도 다기관에 다발적으로 발생하는 경우에는 적용할 수 없다. 지금까지 NF1 의 종양형성과 악성화에 관여하는 몇몇 유전자가 보고되고 있으나, 아직 정확한 기전은 밝혀져 있지 않고 ... See full document
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Roles of TNS3 gene in tumor progression of Neurofibromatosis Type 1
... 6 NF1은 질환의 우성유전으로 인해 50%의 자손에 대물림 되나, 다른 유전질 환과는 특이하게 부모로부터의 유전이 아닌 새로운 돌연변이(de novo mutation)에 의한 경우가 환자의 약 50%에 달하기 때문에 유전질환임에도 불 구하고 환자가 매우 많다(약 3,500명 중 1명 발병). 환자들은 결혼해서 아이 를 가질 것인가에 대한 고민, 다른 사람과 다르다는 ... See full document
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(1) (malignant mixed mesodermal tumor
... MMMT is a highly aggressive and rapidly progressive tumor with a poor long-term prognosis. Though aggressive surgery is generally felt to be indicated for this tumor, there is no uniform opinion about adjuvant therapy. ... See full document
5
BRCA1-associated protein 1 expression and prognostic role in prostate adenocarcinoma
... discussed in a broad spectrum of cancers, consensus has not been reached for it prognostic ...prognosis in clear cell renal cell carcinoma and uveal melanoma ...protective role in ... See full document
7
Complement C1q stimulates the progression of hepatocellular tumor through the activation of discoidin domain receptor 1
... members of a new class of receptor tyrosine kinases (RTKs) characterized by a 155-amino acid discordin homology domain in their extracellular ...consists of two types of non-integrin ... See full document
11
From tumor hypoxia to cancer progression: the implications of hypoxia-inducible factor-1 expression in cancers
... Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan Abstract: Hypoxia, defi ned as a decrease of tissue oxygen levels, represents a fundamental pathophysiological ... See full document
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A functional role of chromatin remodeling factor, Rsf-1 in the DNA damage signaling pathway
... Rsf-1 은 SNF2h 와 함께 RSF 복합체를 구성하는데 둘의 상관관계에 의해서 크로마틴 리모델링 인자의 역할인 뉴클레오솜 구조의 변화를 일으킨다고 알려져 있다. Rsf-1 이 DNA 손상 부위로 모이는 것은 SNF2h 와 관계없이 독립적으로 일어나는 일이며 Rsf-1 이 없을 시 SNF2h 가 DNA 손상 부위로 모이지 않는 것으로 보아 ... See full document
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Characterization of an nf-actin gene in the pathogenic Naegleria fowleri
... (지도교수: 신 호 준) 토양과 담수에서 자유생활을 하는 파울러자유아메바(Naegleria fowleri)는 인체나 실험동물에 원발성 아메바성 수막뇌염을 일으킨다. 파울러자유아메바의 세포사멸기전은 표적세포에 접촉하지 않는 상태에서 아메바의 분비물질에 의해 일어나는 비접촉성기전과 식세포작용처럼 접촉성기전이 있다. 접촉성기전에 의해 표적세포가 용해되는 과정을 trogocytosis라 하며, 이 ... See full document
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Benzo[a]pyrene-induced DNA-protein crosslinks in cultured human lymphocytes and the role of the GSTM1 and GSTT1 genotypes.
... used in this study were obtained from healthy, non-smoking hospital administrative workers who had not been exposed to PAH or other DNA damaging agents by their ...Therefore, the experiments were rela- ... See full document
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The role of local translation in axon survival induced by wldS and sarm1
... axons in nervous system. Non-neuronal cells, especially astrocytes in central nervous system, engulf axonal segments and axons degrades ...apoptosis in regard to active process that eliminates cell ... See full document
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The role of ASK1 in selective striatal lesion formation induced by neuronal injury
... 이에 따라 ASK1의 발현량 조절과 발현량 조절에 따른 분자수준의 변화는 선택적 세포사멸 기전을 이해하는 데 중요한 역할을 할 것으로 예상한다. 한편, innate immune response의 classic pathway의 initiation factor인 C1q의 분비량의 변화 및 이로 인한 microglia activation은 지금까지 중추신경계에서는 ... See full document
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Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells
... to the carboxyl terminus of the amyloid precursor protein (APP) and serves as the bipartite activation enzyme for the ubiquitin-like protein, ...In the present study, we explored ... See full document
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Jazf1 promotes prostate cancer progression by activating JNK/Slug
... protein 1 (Jazf1) is a zinc finger protein and is known to affect both prostate cancer and type 2 ...results in weight loss and alleviates diabetes. However, the role of ... See full document
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The role of RSF1 in DNA damage signaling pathway and DSB-induced transcriptional regulation
... function of RSF1 was demonstrated as a scaffold protein that recruits histone modifiers that write histone post- translational modification for the efficient transcriptional silencing at DSB ...sites ... See full document
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Thioredoxin-1 protects against neutrophilic inflammation and emphysema progression in a mouse model of chronic obstructive pulmonary disease exacerbation
... under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ... See full document
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