[PDF] Top 20 Neuroprotection of AG490 in Oxidative Stress-induced Neuronal Death
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Neuroprotection of AG490 in Oxidative Stress-induced Neuronal Death
... 스의 관계를 알아보고, 산화적 스트레스에 의해 생성된 활성산소의 조절을 관찰 하며, 미토콘드리아의 기능의 변화를 관찰하였다. AG490은 특이적인 산화제에 의 해서 인산화된 JAK2의 인산화를 억제시키고, 약물 자체가 항산화제 활성을 가지 고 있음을 알게 되었다. 약물의 구조적 특징에 의한 항산화제 활성 이외에도 AG490은 세포내의 글루타티온 (GSH)의 양을 ... See full document
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Protective role of <i>Populus tomentiglandulosa</i> against hydrogen peroxide-induced oxidative stress in SH-SY5Y neuronal cells
... activity of PT was evaluated using the method described by Chung et ...µL of extract and four fractions from PT were mixed with 200 µL of 10 mM FeSO 4 ·7H 2 O-EDTA, 200 µL of 10 mM ... See full document
7
Protective effect of Eucommia ulmoides oliver leaves against PM<sub>2.5</sub>-induced oxidative stress in neuronal cells in vitro
... Microglial apoptosis 개선 효과 뇌에서 대식세포의 역할을 하는 microglia인 BV-2 세포는 신경 계의 면역세포로 작용하고, BV-2 세포는 외부 및 내부 자극을 통 해 활성화되어 다양한 전 염증성 사이토카인을 분비한다. 외부 및 내부 자극으로 인한 염증이 과도하게 발생하게 되면, 신경 퇴 화에 관여하는 신경 염증을 유발하게 된다(Bozic 등, 2015). 따라 서 ... See full document
11
Agmatine pretreatment attenuates retinal ganglion cell death by an oxidative stress
... cultures of RGCs have some limitations to study RGC ...number of characteristics of normal RGCs, it is mitotically active and is not exactly same as primary ... See full document
41
Butin (7,3′,4′-trihydroxydihydroflavone) reduces oxidative stress-induced cell death via inhibition of the mitochondria-dependent apoptotic pathway
... elevation of phospho Bcl-2 by H 2 O 2 treatment further helps to reduce its ability to bind with Bax and enhance translocation of Bax from the cytosol to mitochondria, leading to an enhanced susceptibility ... See full document
17
Protective effect of 7,8-dihydroxyflavone against oxidative stress in high glucose-damaged neuronal cells
... Oxidative stress plays a pivotal role in cellular injury induced by ...to oxidative stress [20, ...cell death, apoptosis, and mitochondrial ... See full document
41
Effects of propofol-induced autophagy against oxidative stress in human osteoblasts
... administration of anesthetic agents was found to result in pharmacologic preconditioning against oxidative injury ...be induced under stress conditions ...induction of autophagy ... See full document
9
Protective effect of <i>Eucommia ulmoides</i> oliver leaves against PM<sub>2.5</sub>-induced oxidative stress in neuronal cells <i>in vitro</i>
... Microglial apoptosis 개선 효과 뇌에서 대식세포의 역할을 하는 microglia인 BV-2 세포는 신경 계의 면역세포로 작용하고, BV-2 세포는 외부 및 내부 자극을 통 해 활성화되어 다양한 전 염증성 사이토카인을 분비한다. 외부 및 내부 자극으로 인한 염증이 과도하게 발생하게 되면, 신경 퇴 화에 관여하는 신경 염증을 유발하게 된다(Bozic 등, 2015). 따라 서 ... See full document
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Inducible nitric oxide synthase is involved in neuronal death induced by trimethyltin in the rat hippocampus
... stress 에 의해 생성되는 nitric oxide 와 관련된 inducible nitric oxide synthase 가 높은 연관성을 갖는다고 생각된 다 . TMT 에 의한 신경세포의 사멸이 각 부위에 따라 신 호전달경로의 정도가 다를 것으로 여겨지나 , 구체적인 신호전달 경로의 차이를 규명하기 위해서 추가적인 연 구가 이루어져야 할 것이다 . ... See full document
7
Protective effects of red ginseng treated with gold nanoparticles against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress in neuronal PC-12 cells
... 산화스트레스(oxidative stress) 로부터 신경세포 보호능을 평가하고, 신경전달물질인 아세 틸콜린의 가수분해에 관여하는 아세틸콜린가수분해효소(acetylcho- linesterase, AChE) 및 부틸콜린가수분해효소(butyrylcholinesterase, BChE) 의 활성 억제능을 측정함으로써 황금홍삼 추출물의 인지기 능 개선 소재로서의 가능성을 ... See full document
6
Protective effect of phloroglucinol against gamma radiation-induced oxidative stress in hair follicles
... Departments of 1 Advanced Convergence Technology & Science, 2 Veterinary Medicine, 3 Marine Life Sciences, 4 Civil and Enviromental Engineering, and 5 Nuclear and Energy Engineering, Jeju National University, Jeju ... See full document
7
Protective effect of ethanolic extract of antler-shaped Ganoderma lingzhi against oxidative stress in PC12 neuronal cell line
... Department of Herbal Crop Research, NIHHS, RDA, Eumseong, Chungbuk 27709, ...against oxidative stress in PC12 neuronal cell line, followed by evaluation of their antioxidant ... See full document
5
A study on neuroprotective effects of methyl lucidone on glutamate-induced neuronal cell death in HT-22 neurons
... level of ROS results in neuronal cell death, which contributes to neurodegenerative ...described in primary neuronal cell cultures (Murphy et ...1993), neuronal cell line ... See full document
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LDHB deficiency ameliorates ischemic neuronal cell death
... increased in LDHB deficiency under ischemic condition and how PcomA size is ...is in close connection with ischemic cell death (Michelle et ...metabolism of neuronal cells, according to ... See full document
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JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span
... Activation of c-Jun N-terminal kinase (JNK) signaling in neurons increases stress resistance and extends life span, in part through FOXO-mediated transcription in ...homolog of ... See full document
13
Calcium overload is essential for the acceleration of staurosporine-induced cell death following neuronal differentiation in PC12 cells.
... Differentiation of neuronal cells has been shown to ac- celerate stress-induced cell death, but the underlying mechanisms are not completely ...increase in cytosolic ([Ca 2+ ] c ... See full document
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Angiotensin II potentiates zinc-induced cortical neuronal death by acting on angiotensin II type 2 receptor
... through oxidative stress, the levels of superoxides in zinc-treated neurons were assessed by DCF fluorescence ...levels of superoxides in neurons compared to those induced ... See full document
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Mechanism of ethanol-induced purkinje cell death in developing rat cerebellum: Its Implication in apoptosis and oxidative damage
... ability of oxidative stress to provoke necrotic cell death as a résu1ï of massive cellular damages associated t 。 1ipid peroxidation18) and a1teration of proteins20) and nucleic ... See full document
7
Hepatocyte protection and antioxidant effect of Citri Unshius Pericarpium against cadmium-induced oxidative stress
... analysis of Citri Unshius Pericarpium was analyzed by UPLC with C 18 ...activity of superoxide dismutase (SOD) and the level of reactive oxygen species (ROS) and reduced glutathione (GSH) were ... See full document
11
Phytoceramide shows neuroprotection and ameliorates scopolamine-induced memory impairment
... roles in cell survival and dendrite outgrowth in a dose-dependent manner ...cell death of motoneurons cultures through inhibition of oxidative signals ...level of ceramide ... See full document
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