상단 PDF The Effects of Vitamin D and Sarcopenia on Bone mineral density in Korean women

The Effects of Vitamin D and Sarcopenia on Bone mineral density in Korean women

The Effects of Vitamin D and Sarcopenia on Bone mineral density in Korean women

We analyzed the data from Korean National Health and Nutritional Survey IV in 2009.Women older than age 20 were included for the analyses.Bone mineral density and muscle mass were measured by DXA. Serum vitamin D concentration was tested. Vitamin D and muscle mass affected BMD at proximal femur, but not at lumbar spine. Vitamin D deficiency and sarcopenia increased odd ratio for osteoporosis before and after adjusted for multiple variables. The effects of vitamin D deficiency on BMD still remained significant after adjustment for sarcopenia, which was vice versa.
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Effects of vitamin D deficiency and daily calcium intake on bone mineral density and osteoporosis in Korean postmenopausal woman

Effects of vitamin D deficiency and daily calcium intake on bone mineral density and osteoporosis in Korean postmenopausal woman

2008 and 2009) and KNHANES V (data from 2010 and 2011). These surveys were performed annually by the Korean Minis- try of Health and Welfare with approval from the institutional review board of the Korea Centers for Disease Control and Prevention. Using rolling survey sampling, subjects participat- ed in a complex, stratified, probability cluster survey of a rep- resentative sample in South Korea. About 4,000 households were involved in 2008 and 2009, and about 3,840 house- holds were involved in 2010 and 2011 from January through December of the respective year. A health interview survey, nutrition survey, and health examination survey (physical mea- surements, laboratory test results, BMD level and body mass index [BMI]) were administered. All surveys were conducted by trained interviewers who did not have any information about the participants; surveys were completed during home visit, and they were filled out by the participants or through an interview format. Informed consent was obtained from all participants and the questionnaires were randomly complet- ed. This study was approved by the institutional review board of Severance Hospital, Yonsei University College of Medicine.
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The positive association between peripheral blood cell counts and bone mineral density in postmenopausal women.

The positive association between peripheral blood cell counts and bone mineral density in postmenopausal women.

The BMD is influenced by many factors such as age, body weight, co-morbid conditions, and current use of medications and biochemical markers, 1,26-29 some of which can influence blood cell counts. For example, aging not only causes bone loss but also impairs bone marrow hematopoietic function 30 and decreases blood cell count. To minimize the effects of these potential confounders and to show the independent association between blood cell counts and BMD, subjects with these factors were excluded from study participation and multiple regression was used to adjust for these factors.
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Association between levels of serum ferritin and bone mineral density in Korean premenopausal and postmenopausal women: KNHANES 2008-2010.

Association between levels of serum ferritin and bone mineral density in Korean premenopausal and postmenopausal women: KNHANES 2008-2010.

KNHANES IV and V were each conducted over 3 years (2007–2009 and 2010– 2012, respectively) using a rolling sample survey that involved a complex, stratified, multistage, probability-cluster survey of a representative sample of the non-institutionalized civilian population in South Korea. Sampling units were randomly selected, with 23 households from each primary sampling unit and 200 randomly selected sampling units, yielding 4600 households in 2008, whereas 192 sampling units were randomly selected, with 20 households from each primary sampling unit, yielding 3840 households in 2009 and 2010. The survey was composed of three parts: a health interview survey, a health examination survey, and a nutrition survey. All surveys were conducted by trained interviewers. The interviewers were not provided with any prior information regarding the specific participants before performing the interviews. All participants were provided with written informed consents to participate in this survey, and we received the data in anonymized form. The study was carried out in accordance with the ethical standards of the Helsinki Declaration, and was approved by the Yonsei University Health System, Severance Hospital, Institutional Review Board (4-2013-0706).
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Effects of body composition, leptin and adiponectin on bone mineral density in prepubertal girls

Effects of body composition, leptin and adiponectin on bone mineral density in prepubertal girls

adipokines participate in bone metabolism. Leptin and adiponectin are potential contributors to BMD. Leptin has been proposed to be a mediator of adipose tissue hormonal effect on bone mass 4 . The role of leptin in bone metabolism is not fully understood, but animal studies showed the ‘high bone mass phenotype’ in the leptin deficient mice 32 . In humans, some studies 4, 33, 34 have failed to show any association between serum leptin levels and BMD in women or in men, whereas others have reported a positive association between leptin and BMD 35 . In a few recent studies 36, 37 , leptin was negatively correlated with BMD. In this study, I showed that serum leptin levels were positively correlated with both femoral and L-spine BMD, and leptin was an independent positive predictor of femoral BMD.
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The association between body composition and bone mineral density in subjects aged 50 years or older in men and postmenopausal women in Korea

The association between body composition and bone mineral density in subjects aged 50 years or older in men and postmenopausal women in Korea

* Jeong-Ran Cho* *Professor, Dept. of Health Administration, Kwangju Women’s University, Gwangju, Korea [Abstract] The effect of body composition such as lean mass and fat mass on bone mineral density (BMD) is complex and still controversial. In this study, we investigated the relationship between body composition and bone mineral density using nation-wide data from 2008 to 2011 Korea National Health and Nutrition Examination Survey (KNHANES) in 2,139 men and 2,193 postmenopausal women aged 50 years or older. Subjects with history of medication for osteoporosis or with diseases or malignancy affecting bone metabolism were excluded. Data of anthropometric measurements and demographic characteristics were collected by trained examiner. Fasting blood sample was obtained for blood chemistry analysis. BMD of the lumbar spine, total femur, and femoral neck, and body composition such as total lean mass (TLM), total fat mass (TFM), truncal fat mass (TrFM) were measured using dual-energy X-ray absorptiometry (DXA). There were significant positive correlations between body composition indices such as lean mass and fat mass with BMD. In multiple regression analysis, TLM was positively associated with BMD after adjusting age, body mass index, monthly house income, education level, physical activity, daily calcium intake and vitamin D concentration in both men and postmenopausal women. BMD at lumbar spine and femur in lowest quartile of TLM was significantly lower than other quartiles after adjusting those confounding factors in both gender. TrFM was negatively associated with total femur BMD in male and femur neck BMD in postmenopausal women after adjusting confounding factors. In conclusion, TLM is very important factor in maintaining BMD in subjects aged 50 years or older in men and postmenopausal women.
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Relationship between pulmonary function and bone mineral density in the Korean National Health and Nutrition Examination Survey

Relationship between pulmonary function and bone mineral density in the Korean National Health and Nutrition Examination Survey

The data did not contain information about current medications, such as steroid use, dosage, and duration. Although the effects of inhaled corticosteroids on os- teoporosis and fractures remain controversial, systemic corticosteroids could affect BMD by decreasing new bone formation while increasing bone loss. Indeed, the rate of bone loss correlates loosely with the daily dose and duration of therapy [22]. In addition, pharmacologi- cal treatments of osteoporosis such as bisphosphonates can influence BMD. Smith et al. [23] suggested that alen- dronate improves significantly T- and Z-scores for lum- bar spine BMD, but not for hip BMD, in patients with asthma or COPD. Further studies are needed to under- stand the effects on BMD of corticosteroids and medica- tions for osteoporosis.
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Relationship between pulmonary function and bone mineral density in the Korean National Health and Nutrition Examination Survey (KNHANES)

Relationship between pulmonary function and bone mineral density in the Korean National Health and Nutrition Examination Survey (KNHANES)

23 20 years, and menopause in women was not reflected. Contrary to many other studies, some researchers have failed to find statistically significant difference between BMD values of COPD and non-COPD groups 14,15 . Twenty-eight male COPD patients with a moderate degree of airway obstruction and 20 male volunteer subjects with normal lung function participated in the study. There was no difference in baseline characteristics (age, BMI, dietary parameters) and the level of physical activity between the two groups, except for smoking history. There was no statistically significant difference in the prevalence of osteoporosis between COPD patients and the control healthy group 15 . These discrepancies may be derived from differences in the characteristics of subjects among the studies, such as race, age, gender, menopausal status, history of corticosteroid exposure, and other anthropometric variables. These parameters can contribute to the pathophysiology of osteoporosis in COPD patients 15 .
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Association between dietary carotenoid intake and bone mineral density in Korean adults aged 30–75 years using data from the fourth and fifth korean national health and nutrition examination surveys (2008–2011)

Association between dietary carotenoid intake and bone mineral density in Korean adults aged 30–75 years using data from the fourth and fifth korean national health and nutrition examination surveys (2008–2011)

Our results also revealed that the risk for osteopenia at the lumbar spine was 65% lower in the highest quintile compared with the lowest quintile of dietary β-carotene intake in postmenopausal women. This association did not appear in premenopausal women. Considering that total hip and lumbar spine are highly susceptible to postmenopausal osteoporosis-related fractures [45], this finding in postmenopausal women may be meaningful and helpful for preventing and treating osteopenia. Although the exact reason why this association differs according to menopausal status is currently unknown, the sharp decrease in estrogen level during menopause might be related to such a discrepancy. Differences in β-carotene intake between pre- and postmenopausal women might have also contributed to such results. The β-carotene intake was the highest in our postmenopausal subjects among the intakes of carotenoids, and it was higher than the premenopausal subjects. The food sources considered high in β-carotene concentration were sweet potato, followed by carrot, and kale. Based on our result that a minimum 7.20 mg/day (the highest quintile value) of β-carotene consumption has a positive impact on lowering the risk of osteopenia, at least 85 g/day sweet potato, 87 g/day carrot, and 121 g/day kale consumption might fit the required amount to lower the risk of osteopenia. For β-cryptoxanthin, persimmon was the best source, followed by papaya and paprika.
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Bone mineral density and bone turnover markers in patients on long-term suppressive levothyroxine therapy for differentiated thyroid cancer

Bone mineral density and bone turnover markers in patients on long-term suppressive levothyroxine therapy for differentiated thyroid cancer

However, the effects of suppressive L-T4 therapy on bone density in the Korean population have not been well defined. Purpose: Current management for patients with differentiated thyroid cancer includes near total thyroidectomy and radioactive iodine therapy followed by administration of supraphysiological doses of levothyroxine (L-T4). Although hyperthyroidism is a well known risk factor for osteoporosis, the effects of L-T4 treatment on bone mineral density (BMD) in patients with thyroid cancer do not appear to be as significant as with endogenous hyperthyroidism. In this study, we evaluated the impact of long-term suppressive therapy with L-T4 on BMD and bone turn over markers in Korean female patients receiving L-T4 suppressive therapy.
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Bone mineral density in type 2 diabetic patients aged 50 years or older in men and postmenopausal women in Korea

Bone mineral density in type 2 diabetic patients aged 50 years or older in men and postmenopausal women in Korea

*Professor, Dept. of Health Administration, Kwangju Women’s University, Gwangju, Korea **Professor, Dept. of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea [Abstract] Relationship between bone mineral density (BMD) and type 2 diabetes is still inconsistent. Recently, many epidemiologic data show that fracture risk is increased in type 2 diabetic patients regardless of BMD status. In this study, we used nation-wide data from 2008 to 2011 Korea National Health and Nutrition Examination Survey (KNHANES) to analyze the BMD status in patients with type 2 diabetes compared to non-diabetics. We included subjects aged 50 years or older in men (N=2,959, 2,430 without diabetes, 529 with type 2 diabetes) and postmenopausal women (N=2,902, 2,479 without diabetes, 423 with type 2 diabetes). Subjects with history of medication for osteoporosis or with illness or malignancy affecting bone metabolism were excluded. Data of anthropometric measurements and demographic characteristics were collected by trained examiner. Serum was separated from peripheral venous blood samples obtained after 8 hours of fasting. BMD was measured at lumbar spine and femur using dual-energy X-ray absorptiometry (DXA). There was a significant positive association between lumbar spine BMD and type 2 diabetes after adjusting age, gender, body mass index, monthly house income, education level, physical activity, daily calcium intake and vitamin D concentration by multiple regression analysis in all subjects. In the subgroup analysis by gender, this association was maintained both in male and female after adjusting those confounding factors. However, femur BMD was not different between type 2 diabetic and non-diabetic subjects. In conclusion, lumbar spine BMD was significantly higher in type 2 diabetic patients aged 50 years or more in men and postmenopausal women compared to non-diabetic subjects.
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Factors associated with the bone mineral density in Korean adults: Data from the 2010-2011 Korean National Health and Nutrition Examination Survey (KNHANES) V

Factors associated with the bone mineral density in Korean adults: Data from the 2010-2011 Korean National Health and Nutrition Examination Survey (KNHANES) V

A study of factors influencing the bone mineral density on premenopausal women: Using the 2011 Korean National Health and Nutrition Examination Survey data.. The a[r]

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Vitamin D intake, serum 25OHD, and bone mineral density of Korean adults: Based  on the Korea National Health and Nutrition Examination Survey (KNHANES, 2011)

Vitamin D intake, serum 25OHD, and bone mineral density of Korean adults: Based on the Korea National Health and Nutrition Examination Survey (KNHANES, 2011)

Purpose: The purpose of this study was to estimate dietary intake of vitamin D and the relationship between serum 25- hydroxyvitamin D (25OHD) concentration and bone mineral density (BM[r]

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Bone mineral density and nutritional state according to milk consumption in  Korean postmenopausal women who drink coffee: Using the 2008~2009 Korea  National Health and Nutrition Examination Survey

Bone mineral density and nutritional state according to milk consumption in Korean postmenopausal women who drink coffee: Using the 2008~2009 Korea National Health and Nutrition Examination Survey

coffee only, both coffee & milk, milk only, and none of the above. All data were processed after application of weighted values and adjustment of age, body mass index, physical activity, drinking, and smoking using a general linear model. For analysis of nutrient intake and bone density, data were additionally adjusted by total energy and calcium intake. Results: The coffee & milk group had more subjects younger than 65 yrs and higher education, urban residents, and higher income than any other group. The coffee only group showed somewhat similar characteristics as the none of the above group, which showed the highest percentage of subjects older than 65 and in a lower education and socio-economic state. Body weight, height, body mass index, and lean mass were the highest in coffee & milk group and lowest in the none of the above group. On the other hand, the milk only group showed the lowest values for body mass index and waist circumference, whereas percent body fat did not show any difference among the groups. The coffee and milk group showed the highest bone mineral density in the total femur and lumbar spine as well as the highest nutritional state and most food group intakes, followed by the milk only group, coffee only group, and none of the above group. In the assessment of osteoporosis based on T-score of bone mineral density, although not significant, the coffee and milk group and milk only group, which showed a better nutritional state, included more subjects with a normal bone density, whereas the none of the above group included more subjects with osteoporosis than any other group. Conclusion: Bone mineral density in postmenopausal women might not be affected by coffee drinking if their diets are accompanied by balanced food and nutrient intake including milk.
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Bone mineral density and nutritional state according to milk consumption in Korean postmenopausal women who drink coffee: Using the 2008~2009 Korea National Health and Nutrition Examination Survey

Bone mineral density and nutritional state according to milk consumption in Korean postmenopausal women who drink coffee: Using the 2008~2009 Korea National Health and Nutrition Examination Survey

coffee only, both coffee & milk, milk only, and none of the above. All data were processed after application of weighted values and adjustment of age, body mass index, physical activity, drinking, and smoking using a general linear model. For analysis of nutrient intake and bone density, data were additionally adjusted by total energy and calcium intake. Results: The coffee & milk group had more subjects younger than 65 yrs and higher education, urban residents, and higher income than any other group. The coffee only group showed somewhat similar characteristics as the none of the above group, which showed the highest percentage of subjects older than 65 and in a lower education and socio-economic state. Body weight, height, body mass index, and lean mass were the highest in coffee & milk group and lowest in the none of the above group. On the other hand, the milk only group showed the lowest values for body mass index and waist circumference, whereas percent body fat did not show any difference among the groups. The coffee and milk group showed the highest bone mineral density in the total femur and lumbar spine as well as the highest nutritional state and most food group intakes, followed by the milk only group, coffee only group, and none of the above group. In the assessment of osteoporosis based on T-score of bone mineral density, although not significant, the coffee and milk group and milk only group, which showed a better nutritional state, included more subjects with a normal bone density, whereas the none of the above group included more subjects with osteoporosis than any other group. Conclusion: Bone mineral density in postmenopausal women might not be affected by coffee drinking if their diets are accompanied by balanced food and nutrient intake including milk.
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Relationship between between waist circumference, bone mineral density and bone mineral density in postmenopausal women.

Relationship between between waist circumference, bone mineral density and bone mineral density in postmenopausal women.

Methods: This study included 280 postmenopausal women aged 66 who visited a health care center for checking bone mineral density and height, weight, and waist circumference between Sept[r]

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Association between bone mineral density and remaining teeth in postmenopausal women

Association between bone mineral density and remaining teeth in postmenopausal women

Table 4. Relationships between oral health-related behavior and remaining teeth 골밀도가 낮았고, 잔존치아의 수도 적게 나타났다. 4. 구강건강행태와 잔존치아의 관련성 구강건강 행태와 잔존치아의 관련성을 살펴본 결과 ‘본인인 지 구강건강 상태’(p<0.01), ‘칫솔질 횟수’(p<0.01), ‘보조구강 위생용품 사용여부’(p<0.01) 및 ‘1년간 구강검진 여부’(p<0.01) 에서 유의한 관련성이 있었다. 본인인지 구강건강 상태가 ‘양 호’하다고 생각하는 대상자가 ‘나쁘다’라고 생각하는 대상자 에 비해 잔존치아의 수가 유의하게 많았고 ‘칫솔질 횟수’가 더 보기

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Dietary factors affecting bone mineral density in Korean rural postmenopausal women

Dietary factors affecting bone mineral density in Korean rural postmenopausal women

상태이다. 23) 국외의 폐경 후 여성 골밀도 감소에 관한 장기간의 추적 연구를 살펴보면, 체질량 지수에 관계없이 골밀도는 지 속적으로 감소하며, 골감소를 지연시키는 주된 요인은 체지방 과 폐경전의 높은 골밀도인 것으로 보고되었다. 24) 이는 폐경 후 호르몬 대사와의 관련성으로 25) 지방 조직이 많은 사람은 에스 트로겐[r]

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Decreased bone mineral density is associated with coronary atherosclerosis in healthy postmenopausal women

Decreased bone mineral density is associated with coronary atherosclerosis in healthy postmenopausal women

We attempted to investigate the association between BMD and coronary atherosclerosis using 64-MDCT, which can accurately detect coronary atherosclerosis, even in as- ymptomatic individuals. Reported sensitivity and specificity of 64-MDCT range from 85% to 99% and 86% to 96%, respectively [22-25]. 64-MDCT has also improved the detec- tion of non-calcified plaques, which, compared to calcified plaques, are considered more likely to be unstable and vul- nerable to sudden rupture, subsequently increasing the risk of fatal ischemic cardiac events [26,27]. In another study, a considerable proportion of non-calcified plaques were found in asymptomatic low-risk patients with no, or mild, coronary calcium [28]. Moreover, we included only healthy postmeno- pausal women by excluding participants with a medical history of hypertension, diabetes mellitus, hypercholester- olemia, or cardiovascular disease. Therefore, correlation be- tween BMD and CAD in previous studies and our study BMD is a considerable screening method for coronary atheroscle- rosis in healthy postmenopausal women, thereby facilitating early treatment and better outcomes.
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Relationship between bone mineral density and the remaining teeth in Korean adults

Relationship between bone mineral density and the remaining teeth in Korean adults

* by multiple linear regression analysis Adjusted R 2 =0.146(R 2 =0.172), F=6.6(p<0.001) Table 4. Influencing Factors on the number of remaining teeth of the male 한편 치주질환은 전세계 범발성 질환으로 연령과 함께 증가하며 치조골 흡수와 치주낭 형성으로 성인에 있어 치아 를 상실할 수 있는 첫 번째 원인 질환으로 성인기 이후부터 는 중점적으로 치주질환 예방에 관심을 가지고 구강건강관 리를 하여야 한다. 이에 본 연구에서는 2010년 국민건강영 양조사 제5기 1차년도(2010년) 자료를 이용하여 50대 이후 의 성인을 대상으로 치조골 흡수에 따른 잔존치아수를 구강 건강지표로 설정하고 골밀도와의 관계를 파악하고자 한다.
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