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[PDF] Top 20 Effect of TIS21 on DNA Damage Repair Induced by Etoposide

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Effect of TIS21 on DNA Damage Repair Induced by Etoposide

Effect of TIS21 on DNA Damage Repair Induced by Etoposide

... p53 의 Ser20 잔기 인산화의 감소가 세포사멸 기작에 미치는 영향을 연구하기 위해 BAX, p21 Waf1/Cip1 , NOXA 와 같은 세포사멸에 관계된 단백질 발현을 관찰해본 결과, TIS21 이 과발현 세포에서 세포사멸에 관계된 단백질의 발현이 감소 되어있는 것을 관찰하였다. 또한 caspase 3/7 활성도 및 annexin V 염색이 ... See full document

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Peroxiredoxin II restrains DNA damage-induced death in cancer cells by positively regulating JNK-dependent DNA repair

Peroxiredoxin II restrains DNA damage-induced death in cancer cells by positively regulating JNK-dependent DNA repair

... family of antiox- idant enzymes that detoxify reactive oxygen and nitrogen spe- cies and are distributed throughout the intracellular and extra- cellular ...role of 2-Cys Prxs in the nucleus have not been ... See full document

15

The Effect of Carnosine Extracted from Eels Anguilla japonica on Oxidative DNA Damage Induced by Hydrogen Peroxide and the DNA Repair Capacity of Human Leukocytes

The Effect of Carnosine Extracted from Eels Anguilla japonica on Oxidative DNA Damage Induced by Hydrogen Peroxide and the DNA Repair Capacity of Human Leukocytes

... 구 DNA 의 손상에 효과가 있는 것을 확인하였으며 , 이에 본 연 구에서는 뱀장어로부터 추출한 carnosine 을 이용하여 , 천연물 유래 carnosine 의 기능 특성 규명을 위해 인체 DNA 손상 억 제 및 회복에 미치는 영향 등에 대해 조사함으로써 향후 산업 적 및 의학적으로 중요한 기능성 소재로써 활용이 가능할 것으 로 판단된다 ... See full document

7

Influence of Mercury on the Repair of Ionizing Radiation-induced DNA Damage in Coelomocytes of Eisenia fetida

Influence of Mercury on the Repair of Ionizing Radiation-induced DNA Damage in Coelomocytes of Eisenia fetida

... College of Bioscience and Biotechnology, Chungnam National University, Daejeon 305-764, Korea Abstract - Mercury known as quicksilver, is the most common cause of heavy metal ...caused by excessive ... See full document

5

Effect of Several Drugs of DNA, RNA and Protein Damage induced by Dimethylnitrosamine in Mouse Tissues

Effect of Several Drugs of DNA, RNA and Protein Damage induced by Dimethylnitrosamine in Mouse Tissues

... 거대분자와 결합하여 methyl adduct를 형성하게 된 다.6-10) 특히 DNA와 반응하여 비정상적인 7-methyl- guanine과 0 6-methylguanine을 주로 형성하고 소량 의 다른 메칠화된 nucleotide도 형성한다.11) 그 중 0 6- methylguanine의 형성은 hamster에서 DM N의 투여 용량과 비례적으로 증가하지 않으며, 이것은 비정상 적인 ... See full document

8

The Inhibitory Effect of Phytochemicals on the Oxidative DNA Damage in Lymphocytes by Chrysotile

The Inhibitory Effect of Phytochemicals on the Oxidative DNA Damage in Lymphocytes by Chrysotile

... production by Fenton-like reaction in exposed cells, stimulating phagocytic cells to release extracellular ROS through membrane-associated-NADPH oxidase, and by mitochondrial oxidative phosphorylation ... See full document

6

An Overview on DNA Damage and DNA Repair in Cancer Research

An Overview on DNA Damage and DNA Repair in Cancer Research

... Departments of 1 Biomedical Science, 2 Pharmacology, 3 School of Medicine, Kyung Hee University, Seoul 130-701, Korea There have been a significant number of advances in the field of cancer ... See full document

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Effect of Dendranthema indicum Extracts on Cell and DNA Damage Induced by Oxidative Stress

Effect of Dendranthema indicum Extracts on Cell and DNA Damage Induced by Oxidative Stress

... 국화추출물의 DNA 분절화 억제 활성은 대조군의 89.6%를 보였고, DNA tail의 이동은 농도에 따른 차이는 있으 나 대조군과 비교적 유사한 수준으로 감소되는 경향을 나타내었으며 phospho-H2AX 단백질의 발현은 라디칼 처리군의 ...보여 DNA 인산화를 억제하는 데 높은 활성을 ... See full document

7

The Inhibitory Effect of Polyphenol Oxidase on Polyphenol-Induced DNA Damage of Bacillus subtilis

The Inhibitory Effect of Polyphenol Oxidase on Polyphenol-Induced DNA Damage of Bacillus subtilis

... 영향도 미치지 않았다 (Table III). 본 실험에서 나타난 이러한 결과들은 사과15>나 곰취 , 참취 및 참나물, 적색자두2>의 효소반응 생성물에서 밝혀진 사실들과 도 일치하는 것으로 보아 많은 폴리페놀 화합물이 대부분 돌연 변이원성이 있는 것으로 나타났으나 이러한 특성을 가진 폴리 페놀 화합물이 이들을 산화시키는 효소와 반응하여 갈색화 되 면 변이원성이 급격히 저하되는 것으로 ... See full document

5

Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylase

Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylase

... enhancement of TP promoter activity and this effect was enhanced following the induction of DNA damage-induced ...significance of the promotion of TP transcription by ... See full document

9

Suppressive Effect of Acanthopanax sessiliflorus Extract on the DNA and Cell Damage by Dieldrin

Suppressive Effect of Acanthopanax sessiliflorus Extract on the DNA and Cell Damage by Dieldrin

... one of the organochlorine pesticides (OCPs), induced the damages in neuroblastoma cells and DNA damages in ...extracts of A. sessiliflorus leaves were examined for the suppressive effects ... See full document

6

HMGB1 Switches Alkylating DNA Damage-Induced Apoptosis to Necrosis

HMGB1 Switches Alkylating DNA Damage-Induced Apoptosis to Necrosis

... killing induced by GD and 2-deoxyglucose, a glycolysis ...instead of apoptosis in re- sponse to alkylating DNA damage that induces rapid ATP depletion through PARP activation ...die ... See full document

8

Inhibition of Karyopherin-2 Augments Radiation-Induced Cell Death by Perturbing BRCA1-Mediated DNA Repair

Inhibition of Karyopherin-2 Augments Radiation-Induced Cell Death by Perturbing BRCA1-Mediated DNA Repair

... to DNA damage repair. Knockdown of KPNA2 resulted in accumulation of BRCA1 in the cytoplasm, increased apoptosis, and sensitized the cells to radiation (Figure ...signals of ... See full document

16

The role of ATM responding to DNA damage induced by Xrcc1 deficiency during oligodendrocyte genesis

The role of ATM responding to DNA damage induced by Xrcc1 deficiency during oligodendrocyte genesis

... atrophy 그리고 Leukodystrophy가 나타난 것을 확인하였다.특히 Leuodystrophy의 경우, 희소돌기아교세포 (Oligodendrocyte, OL)의 분화과정 에 문제가 생겨 완전히 분화된 형태인 Myelinating OL세포가 없는 상태로 신경 세포의 신경전달을 느리게 하는 현상이다.Xrcc1 nes-cre ; Atm -/- mouse에서 Myelinating OL의 ... See full document

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Evaluation of DNA Damage Induced by Mercury Chloride (II) and Ionizing Radiation in the Earthworm

Evaluation of DNA Damage Induced by Mercury Chloride (II) and Ionizing Radiation in the Earthworm

... 또한 자연계에 존재하는 다양한 형태의 방사선과 환 경 내 존재하는 유해물질과의 복합작용에 대한 연구는 생물을 대상으로 함에 따라 생물이 받을 영향에 대한 실 질적인 자료를 제공한다. 그러므로 이온화 방사선과 화 학물질의 동시노출에 따른 생물체내의 상승, 가산, 길항 작용 등의 다양한 복합작용 규명 연구의 필요성이 제기 되고 있다. 그 동안 복합 처리에 관한 연구에는 사람 림 프구를 대상으로 ... See full document

6

DNA Repair Enhancement by Radioprotective Ginseng Protein Fraction

DNA Repair Enhancement by Radioprotective Ginseng Protein Fraction

... chemical repair mechanismrepair 능력이 곧 방사선에 대한 방어작용의 결과를 나타내게 된다고 할 수 ...외해 DNA 분자에 형성되는 손상을 ... See full document

6

DNA Damage by Radiation in Tradescantia Leaf Cells

DNA Damage by Radiation in Tradescantia Leaf Cells

... radiation, DNA damage Introduction The comet assay is currently used in different areas of biological sciences to detect DNA ...need of a few cells, is ideal as a short-term ... See full document

2

Hepatoprotective Effect of Bark of Phellodendron amurense RUPR. on Liver Damage Induced by Carbon Tetrachloride

Hepatoprotective Effect of Bark of Phellodendron amurense RUPR. on Liver Damage Induced by Carbon Tetrachloride

... We evaluated the hepatoprotective activity of crude hot-water extracts of the traditional Korean medicinal herb, Phellodendri Cortex (PC; Bark of Phellodendron amurense RUPR.), in an exp[r] ... See full document

8

Antioxidant Activities and Inhibitory Effect on Oxidative DNA Damage of Nelumbinis Semen Extracts

Antioxidant Activities and Inhibitory Effect on Oxidative DNA Damage of Nelumbinis Semen Extracts

... 최근 증가하고 있는 환경오염 물질, 환경 호르몬, 흡연 및 알코올 등은 인체 내 산화적 스트레스를 가중시키고 있다. 그 러나 정상적인 경우에는 체내 항산화 시스템에 의해 제거되지 만 체내 산화-항산화 시스템의 균형이 깨어지면 세포대사과 정 중 발생된 hydrogen peroxide(H 2 O 2 ), superoxide(O 2- ) 그리고 hydroxyl radical(OH - ) 등과 같은 ... See full document

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Protective Effect of Green Tea Extract and EGCG on Ethanol-induced Cytotoxicity and DNA Damage in NIH/3T3 and HepG2 Cells

Protective Effect of Green Tea Extract and EGCG on Ethanol-induced Cytotoxicity and DNA Damage in NIH/3T3 and HepG2 Cells

... 실시하였으며 DNA 손상도는 Comet assay로 실시한 결과 에탄올은 농도의존 적인 세포독성과 유전독성을 ...및 DNA 손상에 대하여 유의성 있는 억제효과를 나타내었으며 DPPH시험과 LDL oxidation 및 8OH-2'dG 생성시험에서 항산화효과를 나타 ...및 DNA 손상억제효과를 나타 ... See full document

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