[PDF] Top 20 Control of proliferation in human mesenchymal stem cells by Secreted Frizzled Related Protein 1

... 인간 중간엽 줄기세포 (이하, hMSC)는 최근 재생의학에 유용하게 사용될 성체 줄기세 포로 여겨지고 있다. 하지만, 체외에서 장기적으로 배양했을 때, 세포의 증식능과 분화능 이 감소하고 세포의 노화가 일어나는 한계를 보인다. 이에 본 연구에서는 세포의 증식과 분화에 밀접하게 관련된 Wnt 신호전달 체계가 hMSC의 자가 증식능에 어떤 영향을 미 치는지를 확인하고자 하였다. 먼저, Wnt ... See full document

... Department of Chemical and Biomolecular Engineering, Patent and Tradement office, Daejeon, 3 Department of Neuroscience, Medical research institute, Ansan Hospital, Korea University, Ansan, 4 Department ... See full document

... shown, in one study, to induce bridg- ing of new bone across large non-union bone defects in 8 individual human patients, there have been no succeeding human surgical studies to confirm ... See full document

... Determination of the mRNA expression levels of upregulated muscle metabolism (A) and autophagy-related markers (B) as myogenic markers in human T-MSCs during the process of ... See full document

... Katagiri 1,2* , Takamasa Kawai 2 , Masashi Osugi 2 , Yukiko Sugimura-Wakayama 2 , Kohei Sakaguchi 2 , Taku Kojima 1 and Tadaharu Kobayashi 1 Abstract Background: For an effective bone graft for ... See full document

... between human and mouse species, the manner in which human MSCs administered in experimental animals are activated and stimulated to function has been ...from human adipose tissue. They ... See full document

... proteins in the area of ...continuous in vivo production of protein at a relative constant level for sustained period 23,49,55 ...Stem cells are defined by their distinct ... See full document

... levels in patients with ...silencing of the SFRP1 gene results in activation of the Wnt pathway in breast car- ...availability of SFRP1 expression as a prognostic ... See full document

... observed in the same liver specimens by confocal laser scanning ...explained by the low amount of eGFP in tissues under the detection threshold for immunohistochemistry but high enough ... See full document

... results of clinical trial of autologous mesenchymal stem cells (MSCs) in patients with severe ischemic stroke (Bang et ...expansion of MSCs is mandatory to meet the dose ... See full document

... The in vitro neural differentiation methods of BMSCs have been investigated by several ...involved in neural development, such as growth factors, neurotrophins, cytokines, and retinoic acid, ... See full document

... characterized by low bone mass and deteriorated microarchitecture, resulting in fragility ...fractures. 1–2 Although multiple risk factors such as advanced age, long-term glucocorticoid use, low body ... See full document

... of gynecology, College of Orinental Medicine, Daegu Haany University 대구한의대학교 한의학과 부인과교실.. 김병회 백승희 ,.[r] ... See full document

... properties of the dentin surface, thereby creating an environment that facilitated DPSC ...important in cell adhesion, and SPP-1 was an abundant noncollagenous bone matrix protein that played ... See full document

... absence of incremental benefit of repeated stem cell treatments, as confirmed by the presence of ...effects of hBMSCs on fertility and early embryonic development following ... See full document

... constitutively secreted high levels of IL- 1Ra, but BM-MSCs and AT-MSCs exhibited a deficiency in IL-1Ra production, which could enable the use of either T-MSCs or T-CM in ... See full document

... view by creating a mutant version of Vax1 that cannot bind to DNA or regulate the transcription of other ...to cells expressing this version of the Vax1 ...growth ... See full document

... the in vivo hepatic differentiation potential of CBMSCs and therapeutic efficacy in chronic liver injury ...immunosuppressed by cyclosporin A, effective repopulation by differentiated ... See full document

... precursor protein binding protein-1 (APP-BP1) binds to the carboxyl terminus of the amyloid precursor protein (APP) and serves as the bipartite activation enzyme for the ... See full document

... Department of Medicine The Graduate School, Yonsei University (Directed by Professor Keungnyun Kim) Regenerative medicine is a leading approach to treating diseases of the central nervous ...benefits ... See full document