tissue inhibitors of metalloproteinase(TIMP)
Changes of Matrix Metalloproteinase and Tissue Inhibitors of Metalloproteinase in Patients with Rotator Cuff Tears
... Matrix metalloproteinase (MMP) is zinc-dependent protease well known to participate in the degradation and remodeling of the extracellular matrix of connective tissues through their broad proteolytic ...
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The expression of a nitric oxide derivative, tissue inhibitors of metalloproteinase-3, and tissue inhibitors of metalloproteinase-4 in chronic periodontitis with type 2 diabetes mellitus JPIS
... pressure of coronary arteries proba- bly stimulated MMP expression, thereby increasing TIMP-4 expression to inhibit inappropriate remodeling of the arterial ...part of the immune response, and it is ...
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Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 levels in Exudative Pleural Effusions
... 단백분해효소(Matrix metalloproteinase, MMP)와 그 내인성 억제제인 금속단백분해효소의 조직억제제 (tissue inhibitors of metalloproteinase, TIMP)들은 감염과 면역질환들의 다양한 병태생리과정들에 관여 하고 있다 4,5 ...
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metalloproteinases (MMPs) and Tissue inhibitors of matrix metalloproteinase-1 (TIMP-1) levels in gingival crevicular
... degradation of the collagenous matrices which support the skeletal framework of gingival complex is due in part to matrix metalloproteinase (MMPs) expressed in situ by inflammatory cells(monocytes, ...
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Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients
... level of each collagenase showed diver- ...sensitivity of the assays used for detect- ing MMPs and TIMPs such as immunohistochemistry, in situ hybridization, zymography, western blots, and northern ...
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Expression of Matrix Metalloproteinase-2 and -13 and Tissue Inhibitor of Metalloproteinase-4 in Varicose Veins
... C The Korean Society for Thoracic and Cardiovascular Surgery. 2011. All right reserved. CC This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ...
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Clinical significance of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase in the induced sputum of TDI-asthma
... Comparison of the levels MMP-9 and TIMP-1 and MMP-9/TIMP-1 ratio in induced sputum of new and chronic TDI -induced asthma patients Group I : newly diagnosed TDI-asthma patients Group II: TDI-asthma patients ...
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Expression of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 after Administration of Endotoxin in Diabetic Rats
... endothelial growth factor) 분비를 통해 신생혈관재생 에도 관여한다고 알려져 있다 11 . 실제로 MMP-9은 천 식, 만성폐쇄성 폐질환, 폐섬유화증, 급성폐손상 등에 서 조직이나 기관지폐포세척액에서 증가되는 것이 확 인되었고 각종 염증세포의 침윤과 기도 내 개형에 관 계된다고 알려졌다. 또한 MMP-9의 작용은 생체 내 에서 분비되는 억제제인 ...
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Prevotella intermedia 의 세균내독소가 치은섬유아세포와 치주인대세포에서의 matrix metalloproteinase 및 tissue
... 있다 24,25) . 세균내독소 (lipopolysaccharide; LPS)는 P . intermedia 와 같은 그람음성 세균의 세포외막의 주 요 성분 중의 하나이다. LPS는 대식세포 등의 숙주세 포를 자극하여 tumor necrosis factor-α, interleukin-1 β, interleukin-6, interleukin-8, 그리고 nitric oxide 등 의 염증매개 ...
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Eosinophil Inflammation of Nasal Polyp Tissue: Relationships withMatrix Metalloproteinases, Tissue Inhibitor of Metalloproteinase-1, andTransforming Growth Factor-1
... sis of MMP-2 and -9, which may be involved in the develop- ment and maintenance of airway inflammation in asthmat- ...enzyme of human mast cell granules (22), degrades fibronectin and cleaves pro ...
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Expression of collagenases (MMP-1,8,13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients
... combination of extracellular matrix, including collagen, relieves pressure and tensile force put on joints, however, when these forces start to hurt articular cells, various kinds of degenerative enzymes ...
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Role of Matrix Metalloproteinase (MMP) 2 and MMP-9 in Soft Tissue Sarcoma
... cells of MFHs showed markedly higher levels of TIMP- 1 and TIMP-2 mRNA expression than ...presence of low concentrations of the inhibitor ...steps of tumor cell invasion and metasta- ...
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The anti-inflammatory role of tissue inhibitor of metalloproteinase-2 in lipopolysaccharide-stimulated microglia
... function of TIMP-2 in microglia has not been demonstrated until ...expression of TIMP-2 in BV2 cells and in primary microglia, and ana- lyzed the TIMP-2 ...effects of TIMP-2 in ...
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HISTOLOGICAL CHANGES AND EXPRESSION OF MATRIX METALLOPROTEINASE-2 AND TISSUE INHIBITOR OF MATRIX METALLOPROTEINASE-2 IN THE CANINE MANDIBULAR CONDYLE AFTER DISTRACTION OSTEOGENESIS
... layer of condylar cartilage, however, their immunoactivity was ...layer of condylar cartilage, however, it demonstrated lack of staining in proliferative ...layer of the condylar ...layer ...
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EXPRESSION OF MATRIX METALLOPROTEINASE-1 AND -2 MRNA IN RETRODISCAL TISSUE OF THE TEMPOROMANDIBULAR JOINT
... 본 연구에서 MMP-2 mRNA는 모든 관절에서 검출이 되었다 (Table 3). MMP-2는 관절원판 후조직에 분포하는 엘라스틴을 분 해하여 17) 관절원판 후조직의 탄력성을 떨어뜨려 비복원성 원판 변위를 지속시키거나, 심화시킬 것으로 추정하였으나, MMP-2 mRNA는 모든 관절에서 발현이 되었다. 측두하악 관절원판이나 Table 6. Frequency of MMP-1 ...
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A novel function of tissue inhibitor of metalloproteinase-1 as a chemoattract molecule for neural stem cells
... expression of TIMP-1 in human brain tumor tissue. Expression of TIMP-1 is increased in human glioma compared with normal tissues using and ...brain tissue, but not normal brain tissue ...
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Matrix metalloproteinases and Tissue inhibitors of matrix metallo- proteinases in gingival crevicular fluids of periodontitis patients
... capable of inhibiting MMPs. The amino group of the N-termi- nal Cys of TIMP co-ordinates with the active site Zn 2+ of MMPs with the adjacent residues of TIMP occupying the active site ...
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Simvastatin as a Modulator of Tissue Remodeling through Inhibition of Matrix Metalloproteinase (MMP) Release from Human Lung Fibroblasts
... capable of activating MMP-2 24 ...capable of activating several of the ...production of MMPs but that maximal collagen degradation is achieved only in the presence of an activator such ...
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Use of gel zymography to examine matrix metalloproteinase (gelatinase) expression in brain tissue or in primary glial cultures.
... set of density ...13Washing of the gel post-electrophoresis is a critical step in this ...ability of gelatinases ability to cleave substrates is ...form of the enzymes, but also the normally ...
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The Effect of Imiquimod on Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Malignant Melanoma Cell Invasion
... characteristics of each cell could be reflected in their response to ...control of MMP-9 expression in melanoma cell lines. Expression of TIMP-1 showed a concentration- dependent increase following ...
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