Mitogen Activated Protein Kinase
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Mitogen-activated Protein Kinase Signaling in Inflammation-related Carcinogenesis
... Inflammation, Mitogen-activated protein kinase INTRODUCTION The innate immune system of mammals recognizes microbial infection and plays its role in elimination of ...
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Water soluble tomato concentrate regulates platelet function via the mitogen-activated protein kinase pathway
... including mitogen-activated protein kinase (MAPK) and PI3K/Akt, were investigated by flow cytometry and immunoblotting, ...and activated partial thromboplastin time (aPTT) were ...
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Carboxyl-terminus of the amyloid protein precursor and ERB are required for estrogenic effect in activating mitogen-activated protein kinase
... 6 precursor protein (APP) in the pathogenesis of Alzheimer's disease, and this effect is mediated by estrogen receptors (ERs) in activating mitogen-activated protein kinase (MAPK)- sig[r] ...
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Pathobiological role of advanced glycation endproducts via mitogen-activated protein kinase dependent pathway in the diabetic vasculopathy.
... via mitogen-activated protein kinase dependent pathway in the diabetic vasculopathy Young Won Yoon 1 , Tae Soo Kang 3 , Byoung Kwon Lee 4 , Woochul Chang 2 , Ki-Chul Hwang 2 , Ji-Hyuck Rhee 1 ...
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Baicalin suppresses lipopolysaccharide-induced matrix metalloproteinase expression: action via the mitogen-activated protein kinase and nuclear factor κB-related protein signaling pathway
... the protein, MMP-1 and MMP-2, without affecting PDLFs’ cell viability, suggesting its possibility because of the inhibition of phosphorylation activation of mitogen-activated protein kinase’s ...
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Compound K Inhibits Interleukin-1β-induced Expression of Inflammatory Mediators and Matrix Metalloproteinases by Inhibiting Mitogen-activated Protein Kinase Activation in Chondrocytes
... Copyright ⓒ 2018 by The Korean College of Rheumatology. All rights reserved. This is a Open Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the ...
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α-Lipoic Acid Prevents Neointimal Hyperplasia Via Induction of p38 Mitogen-Activated Protein Kinase/Nur77-Mediated Apoptosis of Vascular Smooth Muscle Cells and Accelerates Postinjury Reendothelialization
... p38 mitogen-activated protein kinase phosphorylation, and inhibition of p38 mitogen-activated protein kinase completely blocked ALA-induced vascular smooth muscle ...
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Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase- and NF-kappa B-Dependent Pathway, Leading to Modulation of Apoptosis
... Received 2 March 2016 Returned for modification 20 May 2016 Accepted 15 June 2016 Accepted manuscript posted online 20 June 2016 Citation Ko SH, Rho DJ, Jeon JI, Kim Y-J, Woo HA, Lee YK, Kim JM. 2016. Bacteroides ...
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A Formulated Korean Red Ginseng Extract Inhibited Nitric Oxide Production through Akt- and Mitogen Activated Protein Kinase-dependent Heme Oxygenase-1 Upregulation in Lipoteichoic Acid-stimulated Microglial Cells
... and mitogen-activated protein kinase (MAPK) in- hibitors suppressed RGE-mediated expression of HO-1, and RGE enhanced the phosphorylation of Akt, extracellular signal-regulated kinases (ERKs), ...
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Also, in the mitogen-activated protein kinase (MAPK) path-
... water-soluble protein, which derived from silkworm Bombyx ...related protein (TRP)-2 protein expression, compared to neg- ative control, which was similar to the expression of ...
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Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses
... 5. Summary and Perspectives Inflammation has attracted great interest because of its significant role in several major diseases and the need to develop better ways to treat these diseases. Importantly, because ...
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Paclitaxel Suppress Dedifferentiation via Mitogen-activated Protein Kinase Pathway in Rabbit Articular Chondrocyte
... MAP kinase, PKC-α와 PKC-ξ와 같은 세포신호 전달과정을 조절하여 산화질소에 의한 연골세포의 탈분화와 세포 자가사멸을 억제하며 COX-2의 발현을 저해하는 것으로 알려져 있으 나 , JAS에 의한 actin 세포골격의 재구성은 오히려 연골 세포의 탈분화와 COX-2의 발현을 유도하는 것으로 밝 혀졌다 (Kim et ...
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Ribotoxic Stress through p38 Mitogen-activated Protein Kinase Activates in Vitro the Human Pyrin Inflammasome
... Human pyrin with gain-of-function mutations in its B30.2/ SPRY domain causes the autoinflammatory disease familial Mediterranean fever by assembling an ASC-dependent inflam- masome that activates caspase-1. Wild-type ...
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Immunomodulatory effect of the water extract of Aster tataricus through mitogen-activated protein kinase signaling pathway
... IL-1β, interleukin-1β; Conc, concentration; ND, not detected; WAT, water-extracted Aster tataricus; AT, Aster tataricus; TNF-α, tumor necrosis factor-α; MAPK, mitogen-activated protein [r] ...
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Effect of Adrenomedullin on Proliferation and Mitogen-Activated Protein Kinase Activity in Osteosarcoma Cell Lines (MG63, U2OS)
... Fig. 4. Time course of the effects of AM (50 nM) on the cell proliferations of the MG63 and U2OS cells, as determined by the WST-1 assays. The data is reported as the mean±SE. Significantly different from the untreated ...
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Neuroprotective effects of erythropoietin against hypoxic injury via modulation of the mitogen-activated protein kinase pathway and apoptosis
... However, they measured ERK activation shortly after HI injury (at 60 minutes and 90 minutes). Short, transient activation by growth factors under a phy- siologic condition, ERK activation are associated with neuropro- ...
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c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) are involved in Mycobacterium tuberculosis-induced expression of Leukotactin-1.
... RESULTS AND DISCUSSION MTB enhances expression of Lkn-1 and activates MAPKs Our previous study reported the involvement of Lkn-1 in the im- mune response of macrophages against MTB and revealed that MTB infection causes ...
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Effect of low intensity pulsed ultrasound in activating the mitogen-activated protein kinase signaling pathway and inhibition inflammation cytokine synthesis in chondrocytes
... However, it remains unclear how LIPUS influences the ex- act mechanism leading to delayed cell degradation during chondrocyte damage in arthritis. Accordingly, the aim of this study was to elucidate the mechanisms ...
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Anti-allergic Effect of Seungmagalgeun-tang through Suppression of NF-${\kappa}B$ and p38 Mitogen-Activated Protein Kinase Activation in the RBL-2H3 Cells
... tyrosine kinase and mobilization of internal Ca 2+ ...of protein kinase C, MAPKs, NF-κB, and releasing of inflammatory cytokines 15) ...And activated mast cells can production histamine, as ...
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L-ascorbic acid induces apoptosis in human laryngeal epidermoid Hep-2 cells by modulating the nuclear factor kappa-light-chain-enhancer of activated B cells/mitogen-activated protein kinase/Akt signaling pathway
... The Bcl-2 family includes pro-apoptotic molecules such as Bax, Bak, and Bad, which are directly involved in pore formation at the mitochondrial membrane. Bax promotes mitochondrial integrity, dissipates mitochondrial ...
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