induced-cellular senescence
Reduction of tumorigenesis in androgen receptor overexpressed Huh7 cells through TGF-β induced cellular senescence phenotypes
... cells induced cellular senescence phenotypes, such as SA- β- galactosidase activity, nuclear actin translocation, cytoplasmic p-Erk1/2 sequestration and reduced telomerase ...of senescence of ...
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D-galactose induces astrocytic aging and contributes to astrocytoma progression and chemoresistance via cellular senescence
... and induced cellular ...the senescence-associated secretory phenotype (SaSP) can stimulate age-related pathologies and chemoresistance in ...cells induced by d-galactose exhibited increases in ...
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Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer
... trigger senescence instead of apoptosis in ovarian cancer ...Olaparib induced cellular senescence in ovarian cancer Based on the findings where olaparib inhibited cell proliferation, we ...
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Ginsenoside Rh2 Ameliorates Doxorubicin-Induced Senescence Bystander Effect in Breast Carcinoma Cell MDA-MB-231 and Normal Epithelial Cell MCF-10A
... which cellular senescence was initiated in many cancer ...successfully induced cellular senescence of breast carcinomas cell MDA-MB-231 and normal cell MCF-10A, as elaborated by typical ...
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Cellular Senescence in Arterial Diseases
... stress induced DNA damage in VSMCs, which was associated with a reduction in telomerase activity, telomere attrition, and cellular ...AngII induced senescence in VSMCs in Apoe −/− ...
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Enhanced Viral Replication by Cellular Replicative Senescence
... of senescence include replicative senescence through cellular aging, and loss of telomeres and premature senescence induced by a wide range of stressors, including oncogenes and ...
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Cellular Senescence and Inflammaging in the Skin Microenvironment
... of cellular cross-talk between skin microenvironment and ...SASP, Senescence-associate secretory phenotype; SCF, Stem cell factor; SDF-1, Stromal cell-derived factor-1; TGF, Tumor growth factor; Th cells, T ...
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Suppression of Cellular Senescence by Cordycepin in Replicative Aged Human Dermal Fibroblasts
... (Received May 14, 2015; Revised June 2, 2015; Accepted June 9, 2015) 요 약: 세포 노쇠화(cell senescence)는 나이 듦에 따른 내인성 노화 및 질병들에서 나타날 수 있는 세포의 노화인자 발현, 세포분열 정지 등의 현상으로 일컬어진다. 피부세포의 경우, 노화 및 외부요인으로 인한 세포 노쇠화가 일어나 세포분열의 정지 ...
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Ginsenoside Rg3 Prevents Oxidative Stress-Induced Astrocytic Senescence and Ameliorates Senescence Paracrine Effects on Glioblastoma
... astrocytic senescence and SASP in brain aging, which provided a basis for developing strategies to reduce the dark side of senescence in normal or pathological aging ...
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Knockdown of Moesin Expression Accelerates Cellular Senescence of Human Dermal Microvascular Endothelial Cells
... The senescence of vascular endothelial cells is associated with atherosclerosis, hypertension, congestive heart failure, sepsis, diabetes, thrombotic thrombocytopenic purpura, systemic sclerosis, systemic lupus ...
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Protein Kinase CKII Inhibition-Induced Senescence is P53-Dependent
... with cellular senescence but also with organism ...in senescence development induced by CKII inhibition, by using wild-type and isogenic p53(-/-) HCT116 HCT116 human colon cancer cell ...
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Silencing of the CKII${\alpha}$ and ${\alpha}'$ Genes via DNA Methylation during Cellular Senescence
... Seok Young Jang and Young-Seuk Bae School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702-701, Korea Protein kinase CKII is a ubiquitous and highly conserved protein serine/threonine kinase, ...
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
... the senescence fibroblast cells; thus ATP production is insufficient despite increased oxygen ...premature senescence of young HDF ...stress induced senescence ...
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Induction of Cellular Induction Senescence by BTG2_(TIS21/PC3) Gene in Huh7 Hepatocellular carcinoma Cells
... MEF 세포를 분리하였다. 세포노화의 진행 정도는 Senescence associated-β- galactosidase assay (SA-β-gal)와 세포성장율 측정으로 표현하였다. 단백질의 발현과 세포 내 위치변화는 immunoblotting 과 면역형광염색을 수행하여 측정하였다. 세포 내 TIS21 BTG2 발현양은 RT-PCR, Real-time PCR 로 측정하였다. ...
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Regulatory Factors of Cellular Senescence in Human Diploid Fibroblast : SA-p-Erk1/2, PP1/2A, PKCα
... down-regulation induced the decrease of p53, p21 WAF1 , and SA-p-Erk1/2 in mid-old ...of senescence phenotypes, but also for regulation of proliferation ability in cellular ...
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Estrogen inhibits B-RafV600E-induced senescence in human primary ovarian epithelial cells
... oncogene-induced senescence (OIS). In the present study, we observed B- RafV600E induced OIS in ovarian epithelial ...oncogene induced senescence was significantly ...treatment ...
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Testosterone Protects Pancreatic ββ-cells from Apoptosis and Stress-Induced Accelerated Senescence
... Notably, the anti-apoptotic and anti-senescent effect of DHT on pancreatic β-cells should be reserved for only male subjects in the clinical viewpoint. In clini- cal practice, excessive blood androgens in obese women ...
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Nuclear accumulation of G-actin in cellular senescence: Reduced expressions of exportin 6 and Ran small G protein
... D. 노화된 노화된 노화된 노화된 세포에서 세포에서 세포에서 세포에서 exportin 6 의 의 의 발현감소 의 발현감소 발현감소 발현감소 노화가 진행될 때 actin 을 핵 내에서 세포질로 끌고 나오는 기전에 대한 변화 를 관찰하기 위해 actin 을 세포질로 이동시킨다고 새롭게 알려진 exportin 6 에 대한 실험을 진행하였다. 젊은 세포와 replicative ...
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Rice phytochrome B (OsPhyB) negatively regulates dark- and nitrogen starvation-induced leaf senescence
... leaf senescence and light deprivation causes large-scale transcriptional reprogramming to dismantle cellular components and remobilize nutrients to sink organs, such as seeds and storage ...
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TIS21 shifts p53-induced response of EJ bladder carcinoma cells from senescence to apoptosis
... from senescence to apoptosis It has been known that wild type p53 mediates senescence phenotypes and cell death in response to DNA damage signals both in human and ...
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