High Glucose
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Temporal gene expression pattern in podocyte exposed to high glucose
... diabetes. Numerous studies have supported the protective role of PPAR- γ agonist in diabetic nephropathy. Clinical trials with a PPAR- γ agonist have shown that urinary albumin excretion was reduced in patients with type ...
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Effects of High Glucose on Interleukin-6 Production in HumanMesangial Cells
... with high glucose and fetal bovine serum had no additional effects on IL-6 mRNA expression and IL-6 ...the high glucose-induced alter- ations in IL-6 ...normal glucose concen- trations ...
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High glucose stimulates glutamate uptakes in pancreatic β-cellsHo Jae Han
... between high glucose-induced glutamate uptake and oxidative stress has not been ...of high glucose on glutamate uptake in pancreatic ...mM glucose stimulated the glutamate uptake in ...
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Vav3, a GEF for RhoA, Plays a Critical Role under High Glucose Conditions
... metformin-mediated glucose uptake Vav3 was induced under a high-glucose culture condition, im- plying that Vav3 may be associated with high glucose-related pathophysiological ...
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Protective effect of 7,8-dihydroxyflavone against oxidative stress in high glucose-damaged neuronal cells
... hyperglycemia. High glucose level can stimulate free radical ...inhibited high glucose-induced cell death, apoptosis, and mitochondrial ...
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Ginseng Total Saponin Improves Podocyte Hyperpermeability Induced by High Glucose and Advanced Glycosylation Endproducts
... both high glucose- and AGE-added condition induce the distri- butional change and suppress the production of ZO-1 protein, thus causing the phenotypical changes and hyperpermeability of podocytes, which can ...
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Protective Effect of Heme Oxygenase-1 on High Glucose-Induced Pancreatic β-Cell Injury
... at high glucose condition (30 ...the glucose concen- tration in culture media and incubation time with metalopor- phyrin was different from those of our ...the glucose concentration and ...
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Inhibitory effects of curcumin on high glucose-induced damages: Implications for alleviating diabetic complications
... in high glucose-induced protein glycation and intracellular events in mature ...reduced high glucose-induced oxidative stress in a dose dependent manner, whereas CCM treatment time-dependently ...
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Diazoxide Suppresses Mitochondria-dependent Apoptotic Signaling in Endothelial Cells Exposed to High Glucose Media
... to high glucose (HG) ...mM glucose, and the degree of apoptotic cell death associated with activation of the mitochondria-depend- ent apoptotic signaling pathway was ...
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High glucose and palmitate increases bone morphogenic protein 4 expression in human endothelial cells
... Fig. 3. Activation of BMP4 induced by high glucose and FFA ef fects on various adhesion molecues. We used siRNA techniques to selectively deplete BMP4-dependent pathways and examine the effect of HG, PAL, ...
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The Inhibitory Effect of siRNAs on The High Glucose-Induced Overexpression of TGF- 1 in Mesangial Cells
... In summary, in this study, we applied TGF- 1 siRNAs strategy to suppress TGF- 1 overexpression the cell prolif- eration of RMCs induced by a high glucose concentrations. The suppressive effect of TGF- 1 ...
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The relationship between high glucose-induced secretion of IGFs and PKC or oxidative stress in mesangial cells
... The relationship between high glucose-induced secretion of IGFs and PKC or oxidative stress in mesangial cells Soo-hyun Park, Jung-sun Heo, Chang-won Kang1 and Ho-jae Han* Department of [r] ...
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In vivo Screening of Herbal Extracts on High Glucose-induced Changes in Hyaloid-Retinal Vessels of Zebrafish
... 제브라피쉬 치어를 이용한 당뇨병성 망막증 효능 검색 − 혈관내피세포에 특이적으로 형광단백질(Green Fluorescence Protein, GFP)이 발현하는 형질전환 제브라피쉬[Tg(kdrl: EGFP)] 암수를 교배하여 발생배를 획득하였다. 39) 수정 24 시간 째 형광단백질을 발현하는 발생배를 선별하여 24 well plate 에 5 개체씩 분주한 후 30 mM glucose를 ...
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Protective effect of ethyl acetate fraction from Actinidia arguta sprout against high glucose-induced in vitro neurotoxicity
... and high glucose-induced cytotoxicity in human neuroblastoma MC-IXC ...had high total phenolic and total flavonoid ...and high glucose-induced cell death, and inhibited the generation ...
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Oryeong-san Ameliorates High Glucose-induced Mesangial Cell Proliferation
... Results : RMC proliferation under 25 mM glucose was significantly accelerated compared with 5.5 mM glucose, which was inhibited by Oryeong-san in dose dependent manner. Pre-treatment of Oryeong-san induced ...
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
... I. 서 론 A. 당뇨병 (Diabetes Mellitus)의 정의 당뇨병 (Diabetes Mellitus)은 췌장 (pancreas)에서 분비되는 인슐린 (insulin)이 부족하거나 인슐린이 우리 몸에서 제대로 작용하지 못하여 혈당이 에 너지로 이용되지 않고 혈액 속에 쌓여서 고혈당 증상을 나타내는 만성대사질환 이다. 정상인의 경우 체내에 포도당 (glucose)이 흡수되면 ...
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Neuronal Cell Protective Effect of Dendropanax morbifera Extract against High Glucose-Induced Oxidative Stress
... 0.05, and different small letters represent statistical differences. 되어 세포의 손상 및 생존율을 감소시키는 것으로 알려져 있다. 이와 같은 세포의 손상은 활성산소종을 제거하거나 항산화 효소계의 활성을 증진하는 것 등으로 보호받을 수 있는데(28) 황칠나무 잎 분획물은 고농도의 포도당으로 인 한 산화적 스트레스를 효과적으로 경감시켜주는 ...
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Inhibitory Effect of Mori Ramulus on Oxidative Stress Induced by High Glucose in LLC-$PK_1$ Cells
... 이상의 실험결과를 종합해 보면 桑枝는 고농도 glucose 처리에 의한 세포사를 저해하였고, ․O 2 - , NO, ONOO - 의 생성을 억제하였으며, 고농도 glucose 처리로 증가된 AGE, RAGE를 감소시켰다. 또한 NF-κB를 활성화시키는 신호전달계인 MAPKs, PI3K 및 Akt와 NF-κB의 subunit인 핵내 p50, p65 양을 억제함으로써 ...
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Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells
... Treatment with exogenous nicotinamide mononucleotide (NMN) or L-Kynur e ni n ( Kyn) , or nicotinamide adenine dinucleotide (NAD+) prevented HG/PA-induced viability reductio[r] ...
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Anti-inflammatory Activity of Onion Juice Prepared from Sulfur-Fertilized Onions in High Glucose Induced Human Monocytes
... 요 약 고혈당으로 유도된 염증반응 모델에서 유황양파즙(onion juice) 의 항염증 효능을 평가하였다. 고혈당(HG, 25 mM glucose) 조건 하에서 48시간 배양된 THP-1 세포들은 정상혈당(NG, 5.5 mM glucose) 조건의 세포들에 비해 유의적으로 낮은 세포 생존율을 보였으나, 50-150 µL 유황양파즙을 함께 처리하자 NG군 수준으 로 ...
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