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Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors

Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors

... are dopaminergic neurons derived from the substantia nigra of transgenic mouse embryos, are exposed to ATP, cell death ...SN4741 dopaminergic cell death via P2X 7 ...

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Neuroprotective Effect of Human Mesenchymal Stem Cell on Dopaminergic Neurons by Anti-inflammatory Action

Neuroprotective Effect of Human Mesenchymal Stem Cell on Dopaminergic Neurons by Anti-inflammatory Action

... the dopaminergic system is a widespread phenomenon of hMSCs (Blondheim et ...into dopaminergic phenotype, neuroprotective property of hMSCs on dopaminergic neurons through anti-inflammatory ...

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Increased Slc6a4 Expression Associated with Decreased Dopaminergic Neurons in an MPTP Induced Parkinsonism Mouse Model

Increased Slc6a4 Expression Associated with Decreased Dopaminergic Neurons in an MPTP Induced Parkinsonism Mouse Model

... the dopaminergic neurons in the sub- stantia ...on dopaminergic neuronal cell ...and dopaminergic neurons, we performed a study using siRNA of Slc6a4 in the dopaminergic neuronal ...

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Thuja orientalis leaves extract protects dopaminergic neurons against MPTP-induced neurotoxicity via inhibiting inflammatory action

Thuja orientalis leaves extract protects dopaminergic neurons against MPTP-induced neurotoxicity via inhibiting inflammatory action

... We conducted behavioral tests and IHC analysis to see how TOFE affect MPTP-induced neuronal loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) [r] ...

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Phosphorylation of p38 MAPK Induced by Oxidative Stress Is Linked to Activation of Both Caspase-8- and -9-mediated Apoptotic Pathways in Dopaminergic Neurons

Phosphorylation of p38 MAPK Induced by Oxidative Stress Is Linked to Activation of Both Caspase-8- and -9-mediated Apoptotic Pathways in Dopaminergic Neurons

... Immunoblot Analysis—MN9D cells, MN9D/p38DN cells, or primary cultures of dopaminergic neurons were treated with 6-OHDA in the presence or the absence of various inhibitors. Following drug treatment, cells ...

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Neuroprotection of Dopaminergic Neurons by Hominis Placenta Herbal Acupuncture in in vitro and in vivo Models of Parkinson's Disease Induced by MPP+/MPTP Toxicity

Neuroprotection of Dopaminergic Neurons by Hominis Placenta Herbal Acupuncture in in vitro and in vivo Models of Parkinson's Disease Induced by MPP+/MPTP Toxicity

... Ⅳ. Discussion Various types of acupuncture treatment have been used to prove the effects of neuroprotection against nigrostriatal dopaminergic neuronal cell loss. In ani- mal studies, acupuncture and ...

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Mesenchymal stem cells augment neurogenesis in the subventricular zone and enhance differentiation of neural precursor cells into dopaminergic neurons in the substantia nigra of a parkinsonian model

Mesenchymal stem cells augment neurogenesis in the subventricular zone and enhance differentiation of neural precursor cells into dopaminergic neurons in the substantia nigra of a parkinsonian model

... DISCUSSION The present study demonstrated that hMSC adminis- tration significantly augmented neurogenesis in both the SVZ and SN of PD animal models, which led to increased differentiation of NPCs into ...

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  Protects  Dopaminergic  Neurons  in  Rodent  Models  of  Parkinson’s  Disease

Protects Dopaminergic Neurons in Rodent Models of Parkinson’s Disease

... challenges. Activated microglia produce a wide array of cytotoxic factors, including tumor necrosis factor-α (TNF α), interleukin (IL)-1β, eicosanoids, nitric oxide, and reactive oxygen species that impact neurons ...

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Migratory defect of mesencephalic dopaminergic neurons in developing reeler mice

Migratory defect of mesencephalic dopaminergic neurons in developing reeler mice

... mDA neurons in the SNc and widely diffused distribution of RRF neurons in reeler ...mDA neurons occurs by the absence of reelin-dab1 ...mDA neurons in the SNc of reeler is not thought to be ...

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FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase

FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase

... DA neurons where FoxO1 mediates the aforementioned metabolic phenotypes, warrants further ...DA neurons. Since DA and noradrenergic neurons have closely reciprocal interactions 52–55 , elevated ...

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Cannabinoid receptor agonist protects cultured dopaminergic neurons from the death by the proteasomal dysfunction

Cannabinoid receptor agonist protects cultured dopaminergic neurons from the death by the proteasomal dysfunction

... 1 Department of Physical Medicine and Rehabilitation, Dong-Eui Medical Center, Departments of 2 Anatomy and 3 Physical Medicine and Rehabilitation Anatomy, College of Medicine, Kosin University, Busan, Korea Abstract: ...

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Neuroprotective Mechanism of Acupuncture at GB34 for Dopaminergic Neurons in the Striatum of a Parkinson’s Disease Mouse Model

Neuroprotective Mechanism of Acupuncture at GB34 for Dopaminergic Neurons in the Striatum of a Parkinson’s Disease Mouse Model

... suppressing dopaminergic neuronal death and regulating the phosphorylation of protein kinase B(Akt) in substantia nigra(SN) and ...stimulations. Dopaminergic neuronal survival in the SN and the ST, dopamine ...

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Direct lineage reprogramming of mouse fibroblasts to functional midbrain dopaminergic neuronal progenitors

Direct lineage reprogramming of mouse fibroblasts to functional midbrain dopaminergic neuronal progenitors

... midbrain dopaminergic neuronal progenitors (DPs) by temporal expression of the pluripotency factors and environment containing sonic hedgehog and fibroblast growth factor ...the dopaminergic neurons ...

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Striatal Dopaminergic Functioning in Patients with Sporadic and Hereditary Spastic Paraplegias with Parkinsonism

Striatal Dopaminergic Functioning in Patients with Sporadic and Hereditary Spastic Paraplegias with Parkinsonism

... minergic neurons or by administering Levodopa or another dopamine receptor agonist ...of dopaminergic neuron vulnerability in HSP patients raise the possibility that degeneration of central neurons ...

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Differentiation of Human Dental Pulp Stem Cells into Dopaminergic Neuron-like Cells in Vitro

Differentiation of Human Dental Pulp Stem Cells into Dopaminergic Neuron-like Cells in Vitro

... Real-time PCR analysis indicated that when hDPSCs were cultured in neuronal inductive medium, the Nestin transcript levels appeared to be upregulated from stage 3 onward, where- as there was only a minor alteration in ...

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Platelet-derived growth factor가 dopaminergic 신경세포 분화에 미치는 영향

Platelet-derived growth factor가 dopaminergic 신경세포 분화에 미치는 영향

... 국문요약 Platelet-derived growth factor가 dopaminergic 신경세포 분화에 미치는 영향 포유동물의 중추신경계를 구성하고 있는 신경세포와 별아교세포 및 희소돌기아교 세포는 발생초기 뇌실부에 있는 신경상피에서 유래한다. 신경상피에서 유래된 신경간 세포가 중추 신경계의 다양한 형태의 세포로 분화되는 기전은 아직 정확히 밝혀지지 않았으나, 세포외기질과 ...

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Dopaminergic neuronal development in the embryonic mesencephalon of mouse

Dopaminergic neuronal development in the embryonic mesencephalon of mouse

... Results BrdU birthdating studies have been widely used to study neuronal migration in the developing neocortex [16-18]. Because BrdU is integrated into the DNA of S-phase progen- itor cells, it serves as a stable marker ...

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Signal Amplification in Drosophila Olfactory Receptor Neurons

Signal Amplification in Drosophila Olfactory Receptor Neurons

... The study by Ng et al. (2019) revealed a mechanism by which the signal elicited by pheromone is amplified in the ORNs that promote courtship behavior (see Figure 1). The mechanism involves PPK25, a member of DEG/ENaC ...

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Homo replicus: imitation, mirror neurons, and memes

Homo replicus: imitation, mirror neurons, and memes

... College of Liberal Studies, Seoul National University We are imitating animals. True imitation can be defined as a learning to do an act from seeing it done by others. We have been building culture by imitating others’ ...

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Regulation of mGluR7 trafficking by SUMOylatio in neurons

Regulation of mGluR7 trafficking by SUMOylatio in neurons

... HEK293T 세포에 mGl uR7을 과발현 시킨 후,인산화 반응의 활성인자인 PMA를 처리하여 면연침강법과 웨스턴 블로팅으로 mGl uR7의 수모화 반 응을 확인하였을 때,mGl uR7수용체의 수모화 반응이 증가하는 것을 확 인하였다.이러한 결과로 보아 인산화 반응에 의해 수모화 반응이 증가하 는 것을 확인할 수 있었다.이전 보고[r] ...

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