cellular senescence
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Cellular Senescence in Arterial Diseases
... induced senescence in VSMCs in Apoe −/− ...AngII-induced senescence by the suppression of E3 ubiquitin ligase (Mdm2)-induced p53 degradation in ...the senescence-associated secretory ...cell ...
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Cellular Senescence and Inflammaging in the Skin Microenvironment
... toward cellular senescence trigger inflammaging and the subsequent expressions of clinical skin aging phenotypes, such as ...the cellular cross-talks among keratinocytes, melanocytes, and ...
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Knockdown of Moesin Expression Accelerates Cellular Senescence of Human Dermal Microvascular Endothelial Cells
... and cellular components, and regulate the interaction between blood and the surrounding ...The senescence of endothelial cells is closely related to the aging of the adjacent tissues and to age-related ...
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Silencing of the CKII${\alpha}$ and ${\alpha}'$ Genes via DNA Methylation during Cellular Senescence
... Seok Young Jang and Young-Seuk Bae School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702-701, Korea Protein kinase CKII is a ubiquitous and highly conserved protein serine/threonine kinase, ...
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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
... bypasses cellular senescence was investigated using replicative senescence of HDF cells and DMBA-TPA induced carcinogenesis in CD-1 ...of senescence-associated pErk1/2, which regulates ...
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D-galactose induces astrocytic aging and contributes to astrocytoma progression and chemoresistance via cellular senescence
... Abstract. The administration of d-galactose triggers brain aging by poorly understood mechanisms. it is generally recognized that d-galactose induces oxidative stress or affects protein modifications via receptors for ...
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Reduction of tumorigenesis in androgen receptor overexpressed Huh7 cells through TGF-β induced cellular senescence phenotypes
... induced cellular senescence phenotypes, such as SA- β- galactosidase activity, nuclear actin translocation, cytoplasmic p-Erk1/2 sequestration and reduced telomerase ...of senescence of Huh7-AR cells ...
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Regulatory Factors of Cellular Senescence in Human Diploid Fibroblast : SA-p-Erk1/2, PP1/2A, PKCα
... incorporation. PKC is a serine/threonine kinase and regulates signal transduction pathways involved in gene expression, cell proliferation, and differentiation. We also investigated activation and down-regulation of PKCa ...
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Suppression of Cellular Senescence by Cordycepin in Replicative Aged Human Dermal Fibroblasts
... (Received May 14, 2015; Revised June 2, 2015; Accepted June 9, 2015) 요 약: 세포 노쇠화(cell senescence)는 나이 듦에 따른 내인성 노화 및 질병들에서 나타날 수 있는 세포의 노화인자 발현, 세포분열 정지 등의 현상으로 일컬어진다. 피부세포의 경우, 노화 및 외부요인으로 인한 세포 노쇠화가 일어나 세포분열의 정지 ...
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Nuclear accumulation of G-actin in cellular senescence: Reduced expressions of exportin 6 and Ran small G protein
... D. 노화된 노화된 노화된 노화된 세포에서 세포에서 세포에서 세포에서 exportin 6 의 의 의 발현감소 의 발현감소 발현감소 발현감소 노화가 진행될 때 actin 을 핵 내에서 세포질로 끌고 나오는 기전에 대한 변화 를 관찰하기 위해 actin 을 세포질로 이동시킨다고 새롭게 알려진 exportin 6 에 대한 실험을 진행하였다. 젊은 세포와 replicative ...
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Extracts from Gracilaria vermiculophylla Prevent Cellular Senescence and Improve Differentiation Potential in Replicatively Senescent Human Bone Marrow Mesenchymal Stem Cells
... 1 Department of Biology, College of Natural Science, Chosun University, Gwangju 501-759, Korea 2 Department of Life Science, BK21-Plus Research Team for Bioactive Control Technology, Chosun University, Gwangju 501-759, ...
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Enhanced Viral Replication by Cellular Replicative Senescence
... replicative senescence in cells was validated by positive senescence-associated b-galactosidase ...by senescence, whereas IFN-mediated antiviral effect remained robust and potent in virus-infected ...
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Ginsenoside Rg3 Prevents Oxidative Stress-Induced Astrocytic Senescence and Ameliorates Senescence Paracrine Effects on Glioblastoma
... astrocytic senescence; ginsenosides; SASP; brain tumor; inflammation ...is cellular senescence, which have a complex phenotype characterized by irreversible cell-cycle arrest mediated predominated by ...
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Evaluation of premature senescence and senescence biomarkers in carcinoma cells and xenograft mice exposed to single or fractionated irradiation
... CD, eEF1A1 and eEF1B2 expression correlated more closely with the SA- β -Gal labeling index than the accumulation of p53 and p21 did (Figs. 3 and 6), providing further support of our previous report that these molecules ...
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Protein Kinase CKII Inhibition-Induced Senescence is P53-Dependent
... with cellular senescence but also with organism ...in senescence development induced by CKII inhibition, by using wild-type and isogenic p53(-/-) HCT116 HCT116 human colon cancer cell ...marker, ...
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Senescence of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs
... Although cellular senescence helps an organism by sup- pressing life-threatening tumorogenesis 16,17 , it can also be detrimental to the organism by depleting renewable tissues that contain ...
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Tumor stroma with senescence-associated secretory phenotype in steatohepatitic hepatocellular carcinoma
... of cellular senescence, p21 Waf1/Cip1 , and DNA damage, γ-H2AX, are more highly expressed in CAFs from SH-HCCs than those from ...SH-HCCs. Cellular senescence was previously thought to be a ...
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Estrogen inhibits B-RafV600E-induced senescence in human primary ovarian epithelial cells
... ９ 2. Morphology of primary human ovarian epithelial cells (HOSE). Before using HOSE, we used primary mouse ovarian epithelial cells. But, MOSE was maintained for 7 days culture. Therefore, we used primary human ovarian ...
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Induction of Nuclear Enlargement and Senescence by Sirtuin Inhibitors in Glioblastoma Cells
... SA-β-gal, senescence-associated β-galactosidase; Sir2, silent information regulator Sirtuin family members with lysine deacetylase activity are known to play an important role in anti-aging and ...longevity. ...
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Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer
... cancer. Cellular senescence is a process characterized by normal human cells lose their proliferative capacity and depart from the cell cycle into a relatively stable ...that cellular ...
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