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Retinoic Acid-Related Orphan Receptor Alpha Reprograms Glucose Metabolism in Glutamine-Deficient Hepatoma Cells

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Academic year: 2021

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Fig. 1. Glutamine is required for aerobic glycolysis in hepatoma cells. (A) Protein levels of GLS1, LDHA, and RORa and phosphorylation of PDHe1a in human HCC
Fig. 2. RORa expression is induced after glutamine deprivation through ROS production
Fig. 3. Overexpression of RORa alters glucose utilization in hepatoma cells by down-regulation of PDK2
Fig. 4. Inhibition of PDK2 expression by RORa is p21-dependent. (A) Western blotting analysis of p53, p21, and p-pRb protein levels, in HepG2 cells overexpressing RORa (1, 50 multiplicities of infection [MOI]; 11, 100 MOI)
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