Growth inhibitory and antioxidative effects of crude methanolic extract from Euonymus alatus (Thunb.) Sieb on SKBR3 human breast cancer cell line

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Growth inhibitory and antioxidative effects of crude methanolic

extract from Euonymus alatus (Thunb.) Sieb on SKBR3 human breast cancer cell line

Young-Soo Park*, Ji-Young Han*, Tae-Kyun Lee**, Dong-Il Kim*

*Dept. of OB & GY, College of Oriental Medicine, Dongguk University

**Dr. Lee's Traditional Korean Medical Clinic

*동국대학교 한의과대학 부인과학교실, ^**이태균한의원 박영수^*,한지영^*,이태균^**, 김동일^*

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유방암세포주에 대한 귀전우 메탄올 추출물의 성장억제 및 항산화효과 SKBR3

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α

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μ

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0 20 40 60 80 100 120

*

**

0 1 2 5 10 20 20 (mg/ml)

Concentration of CME-EA (mg/ml) Quercetin

The percentage of cell viability

A) B) C) _{1 2}

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Control 0 1 2 5 10 20 50 (mg/ml)

Concentration of CME-EA (mg/ml) Vitamine

The percentage of relative amount of ROS

* *

A) 24 hr incubation

0 100 200 300 400 500 600 700 800 900

**

* *

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Control 0 1 2 5 10 20 50 (mg/ml)

Concentration of CME-EA (mg/ml) ^{Vitamine E}

The percentage of relative amount of ROS

* *

*

* B) 48 hr incubation

0 100 200 300 400 500 600 700 800

2 3 4 5 6 7 8

C on tro l 0 1 2 5 10 20 50 (mg /m l)

C on cen tra tio n o f C M E-E A (mg/m l) Vita m ine E

The percentage of relative amount of ROS

* *

**

* C ) 72 hr in cub atio n

**

*

0 1 00 2 00 3 00 4 00 5 00 6 00 7 00 8 00

1

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Growth inhibitory and antioxidative effects of crude methanolic extract from Euonymus alatus (Thunb.) Sieb on SKBR3 human breast cancer cell line

A) B) C) 1 2

A) B) C) _{1 2}