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￭♣ S-401 ￭
Trends in Rates and Epidemiologic Characteristics of Severe Hypoglycemia among Paitents with T2DM
가톨릭의대
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황도휘, 윤재승, 한경도, 차선아, 안유배, 고승현
The aim of this study was to investigate the rates in the incidence and epidemiologic characteristics of severe hypoglycemia (SH) in the Korean pop- ulation over nine years using the Korean National Health Insurance sample cohort database from 2007 to 2015. Claims and national health examination data for the period from 2007 to 2015 were retrieved from the National Health Insurance System database. Type 2 diabetes, SH, and major comorbid- ities were identified using the International Classification of Diseases 10 codes and medication information. The overall age-standardized rate of SH was 5.7 per 1000 person-years. The average age-standardized rate of SH was 6.2 per 1000 person-years in 2007-2011 and 5.3 per 1000 person-years in 2012-2015. The incidence rate of SH has been steadily decreasing since 2007, and it has sharply declined from 6.2 to 4.7 per 1000 person-years from 2012 to 2015. The rates of SH were highest among the oldest age group (22.8 per 1000 person-years in the patients with ＞80 years), and lowest among the youngest age group (2.7 per 1000 person-years in the patients who were 30-39 years old). The incidence of SH showed a pattern of steadily increas- ing as age increased (P for trend ＜0.001). The incidence of SH in females was higher compared to that of males in all age groups. The incidence rate of SH was higher in rural areas than in urban areas (8.8 per 1000 person-years vs. 6.5 per 1000 person-years, p＜0.001). The lowest incidence was found in Seoul (5.3 per 1000 person-years), and the highest incidence was seen in Jeju island (11.2 per 1000 person-years). To our knowledge, this is the first report regarding the trends in rates and epidemiologic characteristics of SH in Korean type 2 diabetes patients based on the National Health Insurance database. The study reveals an overall trend of decreasing SH incidence in recent years.
￭♣ S-402 ￭
Total Iron Binding Capacity Predicts New-onset Non-Alcoholic Fatty Liver Disease in Healthy Koreans
1건양대학교병원, 2명지병원, 3강북삼성병원
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강상록
1, 김종대
1, 임동미
1, 박근용
1, 이민경
2, 이다영
3, 박세은
3, 이은정
3, 박철영
3, 이원영
3, 박성우
3, 오기원
3Aims: It is well known that ferritin induces hepatic inflammation and Non-alcoholic fatty liver disease (NAFLD). There is not known for association between transferrin and NAFLD. Thus, we investigated the association between total iron biding capacity (TIBC), an indirect marker of transferrin, and incident NAFLD in apparently healthy subjects through a retrospective longitudinal study. Methods: A total of 31,717 participants (mean age, 39.4±6.8 years) in a Kangbuk Samsung Hospital health screening program in 2005 were assessed via cross-sectional analysis. We included 30,699 sub- jects who underwent medical check-up in both 2005 and 2009, and who did not have NAFLD or liver cirrhosis at 2005 for retrospective longitudinal analysis. The odds ratio (OR) for NAFLD development was analyzed according to TIBC tertile. Results: TIBC was higher in the NAFLD group than non-NAFLD (313.67±44.47 vs. 325.63±43.19 umol/L, p＜0.001). TIBC was correlated with ALT, r-GT and fatty liver index in correlational analysis (r
＝0.060 (p＜0.001), r＝0.098 (p＜0.001), and r＝0.140 (p＜0.001) respectively) after full adjustment for covariates. TIBC independently associated with NAFLD in multivariate logistic linear regression analysis. TIBC predicted new onset NAFLD in non-NAFLD subjects in a multivariate linear re- gression analysis; the OR (95% CI) of the 3rd tertile compared to the 1st tertile of TIBC for incident diabetes was 1.290 (1.144-1.454) after full adjust- ment (p＜＝0.001). Conclusions: Although TIBC and ferritin have reverse correlation, TIBC predict new onset NAFLD in apparently healthy Koreans.
