Association between Praziquantel and Cholangiocarcinoma in Patients Infected with Opisthorchis viverrini: A Systematic 5HYLHZDQG0HWD$QDO\VLV

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7011

Praziquantel and Cholangiocarcinoma in Patients Infected with Opisthorchis viverrini: A Meta-Analysis

Asian Pac J Cancer Prev, 14 (11), 7011-7016

Introduction

Parasitic diseases associated with cancer remain common and widespread in tropical countries. In Thailand, OLYHUÁXNHLQIHFWLRQZLWKOpisthorchis viverrini remains an important public health problem due to the traditional KXPDQKDELWRIHDWLQJUDZÀVK7KHHDWLQJRIUDZÀVKDQG

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1Cancer Unit, Srinagarind Hospital, ²Department of Biostatistics and Demography, Faculty of Public Health, ³Department of Surgery, Faculty of Medicine, Khon Kaen University, Thailand *For correspondence: joevajara@gmail.com

Abstract

Background: The liver fluke, Opisthorchis viverrini, and the associated incidence of subsequent cholangiocarcinoma (CCA) are still a public health problem in Thailand, and praziquantel (PZQ) remains the antihelminthic drug of choice for treatment. Evidence in hamsters shows that repeated infection and PZQ treatments could increase the risk of CCA. However, the existing evidence in humans is inconclusive regarding increased risk of CCA with frequency of PZQ intake. Objectives: To investigate the relationship between number of repeated PZQ treatments and CCA in patients with O viverrini infection. Materials and Methods: The reviewed studies were searched in EMBASE, MEDLINE, ProQuest, PubMed and SCOPUS from inception to October,

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and Laird’s estimator. 5HVXOWV Three studies involving 637 patients were included. Based on the random effects model performed in two included studies of 237 patients, the association between PZQ treatments and CCA was QRWVWDWLVWLFDOVLJQLÀFDQWZLWKDSRROHG25RI&,WRConclusions: The present systematic review and meta-analysis provides inconclusive evidence of risk effect of PZQ on increasing the risk of CCA and VLJQLÀFDQWPHWKRGRORJLFDOOLPLWDWLRQV)XUWKHUUHVHDUFKLVXUJHQWO\QHHGHGWRDGGUHVVWKHVKRUWFRPLQJVIRXQG

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Keywords: &KRODQJLRFDUFLQRPDOpisthorchis viverriniUHSHDWHGSUD]LTXDQWHOWUHDWPHQWVV\VWHPDWLFUHYLHZ

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Association between Praziquantel and Cholangiocarcinoma in Patients Infected with Opisthorchis viverrini: A Systematic 5HYLHZDQG0HWD$QDO\VLV

Supot Kamsa-ard

, Malinee Laopaiboon

, Vor Luvira

, Vajarabhongsa Bhudhisawasdi

*

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caused by O viverriniKDVEHHQUHSRUWHGDVRIWKH

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distributed predominantly in the north and northeast -RQJVXNVXQWLJXO6LWKLWKDZRUQDQG+DVZHOO(ONLQV



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available studies in humans have shown unclear evidence RIDQLQFUHDVHGULVNRI&&$ZLWKLQFUHDVHGIUHTXHQF\RI

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Materials and Methods

Types of studies

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CCA.

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Outcome

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Study inclusion/exclusion criteria

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which could not be explained.

Ethnical consideration

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provided in Table 2.

Risk of bias (ROB)

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Across All Included Studies

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the Included Studies

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between PZQ Treatments and CCA

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Discussion

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patients with O viverriniLQIHFWLRQV7KUHHHSLGHPLRORJLFDO

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biopsies. Am J Gastroenterol, , 267-75.

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