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Diazoxide Suppresses Mitochondria-dependent Apoptotic Signaling in Endothelial Cells Exposed to High Glucose Media

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Academic year: 2021

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Fig.  1.  Apoptosis  of  HUVECs  in  high  glucose  media.  A.  Repre- Repre-sentative  micrographs  of  Hoechst  33,258-stained  cell  preparations  after  72  hr  exposure  to  low  (LG,  5.5  mM)  and  high  glucose  (HG,  30  mM)  media
Fig.  3.  Effects  of  caspase  inhibitors  on  high  glucose-induced  apoptosis.  Cells  were  exposed  for  48  hr  to  media   con-taining  30  mM  glucose  in  the  presence  of  different   cas-pase  inhibitors  (each  20  μM),  and  apoptotic  cells
Fig.  6.  Formation  of  mitochondrial  permeability  transition  pores  induced  by  exposure  to  high  glucose
Fig.  8.  Effect  of  diazoxide  on  high  glucose-induced  formation  of  mitochondrial  permeability  transition  pores  and   cyto-chrome  c  release

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