Pulmonary adenocarcinoma with brain metastasis in a Miniature Pincher

전체 글

(1)³¤¥Èó. * .* a. (2004) 44 4 Korean J Vet Res(2004) 44(4) : 621~624. îÚöBzöBãÃçjÿ>RöFz. ;">Á²Î;Á;.ÁJz'ÁRò^ÁfÏ *Þ&v >~"& ³«Òë (²Òß: 2004j 10ú 22¢). Pulmonary adenocarcinoma with brain metastasis in a Miniature Pincher Min-Soo Kang, Hyo-Jung Kwon, Mi-Sun Park, Hwa-Young Youn, Man-Gil Han and Dae-Yong Kim* College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Korea (Accepted= October 22, 2004) Abstract : A 13-year-old female Miniature Pincher was euthanized after suffering from respiratory insufficiency and seizure. At necropsy, firm tan masses approximately 4 to 5 cm in diameter were noted at the right caudal lobe and left cranial lobe of the lung. On cross sections of the cerebellum and the cerebrum, several compressive firm round masses, 0.5 to 1 cm in diameter, were noted. Similar looking nodules were also present in the mediastinal lymph nodes. Histopathologically, the neoplastic masses consisted of cuboidal shape epithelial cells that form glandular structure. The neoplastic cells have hyperchromatic nuclei with prominent nucleoli and moderate amount of cytoplasm. The degree of mitosis was high (4-6/400X). Multiple areas of necrosis, hemorrhage, and tumor emboli were also noted. Metastasis to the mediastinal lymph nodes, pancreas, and brain was confirmed. Based on the gross and histopathologic examinations, a diagnosis of primary metastatic pulmonary adenocarcinoma was made. Clinically recognized neurological signs were therefore due to brain metastasis. Key words : Dog, lung tumor, metastasis, brain. * V. öB~ ö«·~ ;{ B÷öf Î¾ þ'b VV, C Ò 2Æª ö Â>îj r B -æ pf Bö jB ç~² Ã&~º ã Ëj , bî *þ¶ ·Ï~ ®j &ËW ¸j ©b ÒòB [2, 5]. ö ¢^öBº BöB òçb~ *ö ~ ãÃçj ÿ> öBW ö«·j ÚöB ¾r b {~&Vö ²ÿb~ ªç êò 5 ~òö êæ j "¶ ê .¢ ~º : .. öBW ö«·~ Bnêº Ò²ö j Ö Ôf Þb B~ ãÖ 10ò îÒ BÚöB £ 4-5îÒ~ Bj B~º *Ú«· 7 £ 1% Ú¢ N æ [1]. ~æò "ö fBº ~ã J"" >«~ Ã& 5 öÒ ê ¦¦j ~º ãÖ& ô ¾îV r^ö B& Ã&~º º^ö ® . BöB ö« ·~ ï B _f £ 10.8^ W¾ ®«ö V B~ Nº jçræ C&ê : ì . ÿböB~ öBW ö«·f çbW «·" jçbW «·b ª~> «· 7 ^V&æöçb F z(bronchioloalveolar adenocarcinoma) &Ë z~ . B. Ã B. ~»f 13j B z Miniature PincherB B. \º Brain Korea 21 # >~\²R¦8 \j¢ æö )~Ûî . *Corresponding author: Dae-Yong Kim College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Korea [Tel: +82-2-880-1249, Fax: +82-2-879-2736, E-mail: [email protected]]. 621.

(2) 622. ;">Á²Î;Á;FÁJz'ÁRò^Áf&Ï. Fig. 1. Lateral thoracic radiograph of 13-year-old female Miniature Pincher with a history of coughing and seizure. Note the well-circumscribed soft-tissue-dense masses (arrows) in caudodosal lobe and perihilar region of the lung.. Fig. 2. Photomicrograph of a section of lung. Note the neoplastic nodules consisting of cuboidal shaped epithelial cells often forming glandular structures. H&E. Bar = 200 µm.. ÷ööB ^ ¦" î Vb ~ ~ò¢ A ~b¾ ç& ^*>æ p B· ~ ãÃç ÿ >>Ú BÞ&v >~"& ¦³ÿb÷öö ~Ö> î . ¢> Ú¦Ò ~»f jò ç&b öÇ ªj &b¾ Ë Çrf Óê>æ p~ . ~»f 3j" 5j *ö '' FF«· BFj Af : ® . .¦ÒöBº band type~ ^7~ £ Ã& öº ßê ç²Òf &V>æ p~ . o¦OÒ F ¦Ò¢ Ö" ö^ ¦*f Êã# ¦*ö ¦ ç &ê~ ö; r' &V>î (Fig. 1). öË~ ÷æf öBW ö«· $º FF«·~ *ö ~ © b ~>î &Ãº»b êÛBf V&æ {ËB ¢ ¾O ~&b¾, ç& ^*>æ p ~ò B 5¢ êö n£Ò¢ ~& . ö«j *~ &¦Ò¢ ê ¢>' ¦¦ Fö ~B ¦¦j ~& . ¦¦ ê "º. îËVº ÷Òç' ¦Ò¢ *~ 10% 7W öÖö ;Î ê Ûç' ç¾Ò";j ö 2¢fö ~& . 2¢f çj 4 µm~ vþ ;. r hematoxylin & eosin(H&E) "ïj ~& . ¦¦ öËöBº çã 4-5 cm ;ê~ FW ï ö;~ Ö. ¢ãö ã# Êã¦ª" Jã ö Êã,öB &V>î . «Ï â*.f ;çVö j B 5V ç «&>Ú ®îb îöº ö ËöB &V>î~ ©" FÒ Ö. ÖÒ~ ® î . *Ëf ~² «c 5 B'>Ú ®î . òöB º . çã 0.5 cmf 1.0 cm~ ê «ò . WïÖ. &òf ²ò~ bî¦*ö *~~ ®b "æçj ~² {;~ ®î . ÷Òç' &V Ö", Gn'b {>î~ ö Ë~ Ö. f F ç ·~ ªzB «O;~ «·W çb^ W>îb, Ö.~ 7¦öº *_ Z Ò 5 Â. &V>î (Fig. 2). «·^~ ^îf. ² ³¦ Þ ³"B j &æ ®î . 2B ç~ ²Ú¢ &ê ^ ê > &V>îb, ª çê 400V~ ¢öB 4-6B ôf >& &V>î. . "æç"~ ãêº &Ú ®«{~&b J W WËj ¾æÚî ¢¦ .&~ Ú;öº «·^. Fig. 3. Photomicrograph of a section of cerebellum. Note a well-demarcated metastatic nodule in the cerebellum. H&E. Bar = 100 µm..

(3) îÚö BzöB ãÃçj ÿ>R öFz. ~ ÷£ &V>î . «Ï â*.~ bî" >î ¦* f òËöBê öËöB &V>î~ ©" FÒ ·ç b «O; ^~ «·W Ã &V>îb, ~ "æ îçf ~² {;>î¾ 2Z>Ú ®º ·çj ¾æÚî . ²ò 5 &ò~ î ¦*öB ê ÿ¢ ;~ «·W Ã &V>î (Fig. 3). F F¦*öBº ç' &V Ö" «·W ÷æj { > ìîb Væ îËVöBê ß ÷Ò ç' æz& &V>æ p~ .. V. ö«·f Ò²" Ò Bf ·öBº jv' bæò 7ºãê¢ îËV~ *& ¾ ¢Ú¾º ©b rJ^ ® [6-8]. ö«·~ 7º ºbº ¾, F*' ², Bzbîö~ Â . BöB~ ö«·f *Ú B «· 7 1%¢ N æ~, ê" ¦¦ö ê& ®Ú B B jNf ¢>'b rJê B nê z ¸j ©b Òò B . Ò Bf ·~ ï>« ËNö V¢ ¶'b Ã&~º º^ö ® [7-9]. ö«·f «· ~ V, ;f *~ö V¢ «· ööB öB © æ¢ ' " > ® [1]. Ò²öBº " ç¦ V ê çböB F¾~ ö^ "*öB «· Ö. B . > BöBº ^V&æöçb Fz~ jN ¸b ¢¦ ãÖöBº öË î *>ö >~ Ö. j ;W [1]. .º 7ºãê~ *¢ ÿ> «·b, ÷ Kçb ~>î~ FF«·~ &ËWf ¦¦ 5 ÷ Òç' &Vj Û~ VB > ®î . OÒF Ò êçb öö v B~ «· Ö. &V>î ÷ Òç' &V Ö"öB ^V&æöçböB F ¾ 6b Ú " r ö& öB ¦* ©b 'B . ÷Òç' &V Ö" «O;~ çb^ W> *îf 'Ú j~ öf FÒ ¢ º Fzb {>î . ^V&æöçb Fzf. Fzö jB ç&'b Ôf ö"çb $º «O çb^ W>Ú ®b ;{ êj * Bº *¶*ã çöB II; öçböB &V>º R« ªj "ã¾ ¢¢ ^öB &V>º Z"ã ^ î^j {~º © jº~ [1]. ãÃçf öBW ö«· ò~ * ~ ¾æÂ ©b ÒòB . ¢>' kW«·~ ãÖ . ~¢ Û ò~ *& Úæ² > B n ê& .f ? ²ïî ¦*öB ¸ [10]. ¢>' öBW ò«· &ò ~ *~vªö & O. 623. & ç&'b ² >Ú ò*êç~ æz¢ &V~ öBW ò«·j 6ê~º êæj * > ® [10]. ~æò ªçöB ¢>' öBW ö«·~ ;{ ê" ~ò¢ *Bº V&Â¶ ^¿ $º ö¦ 7º~ [3, 4].. Ö V .º 13Ú~ z Miniature PincherB ^. ¦, îV 5 ãÃç b ~ BÞ&v >~"& ¦³ÿb ÷öö Úö~&b¾ Ã^& ^* >æ pj n£Ò¢ ~& . ¦¦ ê, Gn'b ö Ë" «Ï â*.öB V& · FWï Ö. . > &V>î ²òf &ò~ î ¦*ö {;W~ Ö.j { > ®î . ÷Òç' &V Ö", « Ï â*., òË, &ò 5 ²òö *¢ ÿ> öBW ö«·b 6«>î . ªç'b &V>î~ ãÃ çf ²ò~ *ö ~ Ö" 6>î . ö ¢^öBº ÚöB *W ö«·ö ~ ãÃç ÿ>B .¢ {~&Vö ªçêò¾ ~òö êæ >V * Ö"¢ ~º : .. ^^ò 1. Donald, J. M. Tumors in domestic animals, pp. 380392. Iowa state press, Iowa, 2002. 2. Gillett, N. A., Stegelmeier, B. L., Kelly, G., Haley, P. J. and Hahn, F. F. Expression of epidermal growth factor receptor in plutonium-239-induced lung neoplasms in dogs. Vet. Pathol. 1992, 29, 46-52. 3. Hawkins, E. C., DeNicola, D. B. and Kuehn, N. F. Bronchoalveolar lavage in the evaluation of pulmonary disease in the dog and cat. State of the art. J. Vet. Intern. Med. 1990, 4, 267-274. 4. Hawkins, E. C., Morrison, W. B., DeNicola, D. B. and Blevins, W. E. Cytologic analysis of bronchoalveolar lavage fluid from 47 dogs with multicentric malignant lymphoma. J. Am. Vet. Med. Assoc. 1993, 203, 14181425. 5. Humphery, E. W., Ewing, S. L., Wrigley, J. V., Northrup, W. F. 3rd, Kersten, T. E., Mayer, J. E. and Varco, R. L. The production of malignant tumors of the lung and pleura in dogs from intratracheal asbestos instillation and cigarette smoking. Cancer. 1981, 47, 1994-1999. 6. Jones, T. C., Hunt, R. D. and King, N. W. Veterinary.

(4) 624. ;">Á²Î;Á;FÁJz'ÁRò^Áf&Ï. pathology, pp. 971-972. 6th ed. Williams & Wilkins, Maryland, 1997. 7. Moore, J. A. and Taylor, H. W. Primary pulmonary adenocarcinoma with brain stem metastasis in a dog. J. Am. Vet. Med. Assoc. 1988, 192, 219-221. 8. Redman, H. C., Hahn, F. F. and Muggenburg, B. A. Electroencephalographic correlates of a metastatic brain tumor in a beagle dog. Am. J. Vet. Res. 1973, 34, 681-. 684. 9. Sorjonen, D. C., Braund, K. G. and Hoff, E. J. Paraplegia and subclinical neuromyopathy associated with a primary lung tumor in a dog. J. Am. Vet. Med. Assoc. 1982, 180, 1209-1211. 10. Stunzi, H., Head, M. W. and Nielsen, S. W. Tumors of the lung. Bull. World Health Organ. 1974, 50, 9-19..

(5)