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헬리코박터 파일로리에 감염된 위 상피세포에서 DNA 이중나선절단 관찰

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Fig. 1. Immunohistochemistry for  γH2AX and phospho-53BP1 proteins were detected in the nuclei of epithelial and interstitial inflammatory  cells of the gastric mucosa (×200)
Fig. 2. Change of  γH2AX and phospho-53BP1 expressions in the gastric epithelial cells of 44 patients following eradication of Helicobacter pylori (H

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In the pres- ent study, we used 53BP1 knockdown U2OS, HeLa, knockout H1299 p53-deficient cells, and 53BP1 −/− mouse embryonic fibroblasts (MEF) to investigate