The Korean Journal of Internal Medicine Vol. 29, No. 5 (Suppl. 1)
WCIM 2014 SEOUL KOREA 27
Slide Session
OS-GAS-21 Gastroenterology
Analysis of Clinical Outcome of Biliary Vs. Non-Biliary Pancreatitis – Audit of 5 Years Experience at Aga Khan University Hospital (AKUH)
Shoukat Ali Amyna JIWANI1 Aga Khan University Hospital, Pakistan1
Objective: There is limited knowledge about the outcomes of acute biliary pancrea- titis as compared to non-biliary causes. The objective of our study was to audit our experience at Aga Khan University Hospital with a view to summarize the difference between clinical outcomes of biliary vs. non-biliary acute pancreatitis.
Material and Methodology: 351 adult patients who presented to AKUH between Jan 2009 and Dec 2013 with acute pancreatitis were included in the study. The data were retrospectively collected on a designed performa. Depending on the underlying etiolo- gy, the patients with biliary pancreatitis were compared with non-biliary type in terms of age, gender, co-morbid conditions, severity of the disease, need for intervention(s), need for ICU, length of hospital stay, morbidity, and mortality. Mean and standard de- viation were used for continuous variables and chi square test was used for statistical analysis of categorical data.
Results: The proportion of biliary vs. non-biliary pancreatitis was similar in our study.
Non-biliary acute pancreatitis was more common in younger age (62.4%; p=0.003) and males (60.7%; p=0.001), as compared to biliary group. The proportion of patients with severe pancreatitis (p=0.052), organ failure (p=0.076), infected pancreatic ne- crosis (0.067), and need for surgical intervention (p=0.06) was comparable in the two groups. The need for ICU stay (p=0.042), and overall mortality rate (1.73% vs. 9.8 %, p=0.002) was higher in the non-biliary group.
Conclusion: Non-biliary acute pancreatitis was as common as biliary pancreatitis in our population, but seems to have higher mortality. The work up for non-biliary pan- creatitis needs to be standardized.
OS-GAS-22 Nutrition
Difference Effect among Given Soybean Powder (Gly- cine Max) Infusion, Oyster Mushroom (Pleurotus Os- treatus), and a Mixture of Both on Ldl-Cholesterol Level, Liver Ldl-Receptor Gene Expression, and Greater Omentum Weight of Hyperlipidemia Mice
Suganda Rizky PRAWIRADILAGA1 UNISBA Medical Faculty, Indonesia1
Background: Hyperlipidemia and abdominal obesity are a risk factor for cardiovascular disease. Need an effective solution with natural substance like soy and oyster mushrooms.
Methods: This research was an experimental laboratory using a control group posttest only design. Twenty male mice were divided in fi ve treatment groups, A)standard diet, B) induction of cholesterol, C)soybean infuse with cholesterol induction, D)oyster mush- rooms infuse with cholesterol induction, and E)mixed infuse with cholesterol induction.
At the end of the study mice were dissected for blood drawn from the heart, taken little part of his liver, and the greater-omentum were taken.
Results: The results of blood LDL-cholesterol measurement group E (12 ± 5.48 mg/
dL) similar to group D (12 ± 6.06 mg/dL) but lower than group C (15 ± 5.35 mg/dL) and group B (13.5 ± 5.45 mg/dL) but they were not signifi cant. Moderate LDLR gene expression was found in group A and group C, a weak LDLR gene expression in group B, and no expression LDLR gene in group D and group E. Measurement results of great- er-omentum wet weight group E (0.40±0.07 g) was lower than in group A (0.55±0.07 g), B (0.8±0.49 g), C (1,28±0.28 g), D (0.74±0.11 g), with signifi cance level signifi cant (p<0.05). Measurement results of greater omentum dry weight group E(0.16±0.03 g) was lower than in group B (0.27±0.25 g), C (0.39±0.06 g), D (0,31±0.07 g), and they were signifi cant (p=0.025).
Conclusions: These results conclude that soy infuse at 100mg/day dose increase blood LDL-cholesterol levels and increase the weight of greater-omentum, whereas the op- posite oyster mushrooms at 75mg/day lower blood LDL-cholesterol levels and reduce the weight of greater-omentum.
OS-GAS-23 Nutrition
Relationship Between BMI and Body Fat Percentage with Degrees of Hypertension Using the Equation (An Observation in Bandung Pasirkaliki Phc)
Qurrata A’YUNIN1, Suganda Rizky PRAWIRADILAGA1 UNISBA Medical Faculty, Indonesia1
Background: Obesity is serious health problem. According to WHO 2008, more than half billion of people in the world suffering for obesity, in Indonesia 27,1% of people get obese (Riskesdas 2010). Obesity is the major risk factor for many crhonic dis- ease, including hypertension. Hypertension accounted for 40-50% adult in the world (WHO,2012). Hypertension is the most of 7th cases for inpatient disease in Hospital in Indonesia (Indonesia Health Profi le 2011). The incidence of hypertension is also infl u- enced by high % body fat.
Methods: A cross-sectional analysis conducted in 44 hypertensive subjects aged 20- 59 years in Puskemas Pasirkaliki Bandung, with 19 patients which had fi rst-degree hypertension, and 25 patients which had second degree hypertension. Body weight, body height, and Waist Circumference (WC) had been measured to get the value of Body Mass Index (BMI) and % body fat wich use the equation of BMI and WC were obtained. The bivariable analysis was done using Chi-square Test, and multivariable analysis using Multiple Logistic Regression Test.
Results: The result shows association between BMI and % body fat with degree of hypertension (BMI, p =0,034; % body fat p = 0,013 for equation with BMI, and p = 0,019 for equation with WC). The result of multivariable analysis showed BMI dominantly signifi cant (beta value = 1,340).
Conclusions: There are a signifi cant association between BMI and % body fat wich is use the equation of BMI and WC with blood pressure, the higher BMI and % body fat, the higher a person’s systolic and diastolic blood pressure (degree of hypertension increases) will get. BMI has a dominant association with the degree of hypertension.
OS-HEM-01 Hematology
Immunosuppressive Therapy in Patients with Aplastic Anemia: A Single-Center Retrospective Study
Hassan JALAEIKHOO1, Ahmad KHAJEH-MEHRIZI2, Manoutchehr KEYHANI2, Iraj KHOSROWNIA3
Aja University of Medical Sciences, Iran1, Tehran University of Medical Sciences, Iran2, Chairman of the Society of Iranian Internal Medicine, Iran3
Background: Aplastic anemia (AA) is a rare hematological disease which is charac- terized by peripheral pancytopenia and hypocellular bone marrow in the absence of malignant infi ltration or hyperplasia of reticulin fi bers. The incidence of AA in Amer- ican and European countries is around 0.23 per 100000 population per year while its incidence increases to 0.39–0.50 per 100000 population per year in Asian countries.
Methods: All patients with AA who received IST at Imam Reza hospital in Tehran between May 1998 and September 2013 were identifi ed for this retrospective study.
Patients were included in this analysis if they fulfi lled the criteria for AA and did not have access to HSCT. Bone marrow fl ow cytometry for ruling out the other causes of pancytopenia and serology examination for hepatitis A, B, C, E, Epstein barr virus (EBV) and Parvovirus B19 was carried out in all the patients.
Results: Among the 63 studied patients, 29 (46%) had NSAA and 34 (54%) had SAA.
Three patients had VSAA that were classifi ed as SAA in the analysis. Twelve (19%) patients treated with ATG, CsA and danazol while 51 (81%) patients received CsA and danazol. Three patients had hepatitis associated AA; 2 of them were positive for hepa- titis C and 1 of them had seronegative hepatitis. Two patients were positive for parvo- virus B19. Four patients were followed after exposure to chemicals and one patient had history of taking D-penicillamine. Characteristics of studied patients are shown in Table.
Conclusions: Our results indicated that patients with AA which unable to receive HSCT, could be strongly treated by IST. Also, our experience indicated that IST should not be discontinued after response to therapy in patient with both NSAA and SAA due to high risk of relapse. Low dose of CsA should be continued indefi nitely.
