Journal of The Korean Glaucoma Society
JOURNAL OF THE KOREAN GLAUCOMA SOCIETY 6
서 론
פֳણਉܟѿઌਁઅനਕലࠊৈࠋࣥടؘކऀહ ઌ१३ӄ࠾ઑઊ߸ઝ্ܱ੶ࣛ०ઊ֢േݩ ઊࣛਊઊࣛ੭હ࠹൛ڢਉܟѿઌڝઊӚਉടؘ
ҫ੶ܾࣥҀടӋઔدਉܟӴਁࣳࡂઊפֳણઅ
ઌ੶ܾࡂӋടӋઔӋࣛ०અҿӘؘܾۙԓਕ ലઊؘઌ੶ܾ࣒൛હफ़ಠܩफ़R[LGDWLYHVWUHVVѿઍ
ીਊഢഢҫઊ܅ӋࣥҀടӋઔ੶פֳણਁࣳ१३ӄ
छࣛઅமӖ౿ӄܾઅഡࡘ࡚ઍҫઊ܅ؘࡂӋڝઊઔد
࣒൛હफ़ಠܩफ़ؘࣛ०੶ܾ٩੭ࠋٽ़ઔކ҆ਐ
ଖ࠾ކऀਐ१࡚ࡻٻؘF\WRNLQHઊ֢٪ऀߜଖളേڢઊ
ઔڹ३હ੶ؘܾۙӵघહ੶ܾछ़ࣛઔد
+S\ORULؘJUDPQHJDWLYHPLFURDHURSKLOLFEDFWHULXPઊಡ ଛહ੶ܾઽޅਁFRORQ\ݴઊݗӋࣔӋކऀਐઊ֢
८ઊણԇ৩ઍ੶ౄؘઌԑ੶্ܾܱدܾґࠒ ٩ࣛӵਁ֢ઊѿއ़ܿઊ൝ੰઊѿഡدӋٻৰઔ੶
ੌݼ֢܅ؘ16ंઊࣛઌӴਁࣳ5467ી٩ܾࡂӋٻ Ӌઔدਁࣳކથടَ+S\ORULѿ७ણଖ൝ࠃײ३ӄ ଖ൝ӘӚऀઊઔઊࡂӋٻࣳെથ+S\ORUL ҆ਐ
ਐऀ३ଖ൝੶ܾઊനٻӋઔدਁؘࣳFHQWUDOVHURXV
FKRULRUHWLQRSDWK\DQWHULRUXYHLWLVEOHSKDULWLV%HKFHW’VGLVHDVH
ڢਁࣳӚऀઊઔࡂӋടӋઔ੶ઊܟഡઊ݀હࠔ ӄࠅౕ੶ܾKHOLFREDFWHUS\ORUL+S\ORULઅӚऀਁفഡ
Ӵ٩ࡂӋٻӋઔدെથԪ্ܱଔפֳણਁࣳ+S\ORUL ਭઅӚऀਁفന্ৈࡂӋઘഡد
본 론
פֳણӘઅ Ӛऀਁ فഡ Ӵؘ2000ך *UHHFHઅ 'U
.RXQWRXUDVਁઅന१ઙٻৼӋԓઊ൲ҎJURXSਁࣳ
އӴݴࡂӋടਔدԓڝઊࠋഡࠋґࠒҀפֳણਁ
ࣳઅӚऀਁفഡࡂӋݴࡂפֳણ൝ઘਁࣳ+S\ORUL҆
ਐੰઊીࣛਁࡻനӋઊؘSVHXGRH[IROLDWLRQ൝ઘਁࣳ٩
ࡻ॥ടਔدӋടਔ੶घ़ઊކ+S\ORULݴௗݑഡӄੌਁ
Ә१ৡҩ࣏અ৩ࣛઊઔৼࡂӋടਔد1ۙ ഡפֳણ൝ઘઅৗࠒ़ਁࣳ+S\ORULVSHFLILF,J*ѿથത
ࡂӋടਔد2ઊ൲ਁౡౄઊ܇ૻӵઌ٩ڢਉܟ֢܅ਁ
ࣳפֳણӘ+S\ORULѿӚऀઊઔઊࡂӋٻৼدടކ
ӴਁؘࣳӚऀࡆ़৺دӋടਉৈଓԪؘ+
S\ORULਭפֳણӘઅӚӆਁفഡңѿࡘഡࣛൠઊ
ًӴѿചടدӋടҸد
ੌݼ֢܅ਁ٩+S\ORUL҆ਐӘӚӆټࡂӋڝઊઔؘٙ&KRL
&<HWDO33RVQHU6FKORVVPDQ൲Ӷ൝ઘਁࣳ+S\ORUL҆ਐ
ੰઊીࣛઌਁࡻനدӋടਔ੶410.LP-0HWDO1113೩ ٩ޅਐ൝ઘૻઊࣛ०ഡӄੌਁࣛ०ࡂઊৌ
َӄੌਭࡻӯയڹ+S\ORUL҆ਐੰઊًৈৰۄ
Ӛऀઊઔ१࣏ടؘࡂӋݴടਔد.LP-0HWDO12+
S\ORUL҆ਐઊٳ৩ਁࣳއીࣛפֳણਁࣳ٩Ӛऀઊ
ઔدؘࡂӋݴടਔدઊӴؘ࠾ࠒߚഡ൝ઘਭف
ӶԓݼӋҥҋҩଔ൝ઘૻפֳણ൝ઘਭفӶ੶ܾ֢ৰ
ࡻӯ࡚ࣴടਔؘٙزؘۙ৩અפֳણ൝ઘ֢ી٩ ѿৢടң֢७ഡી٩ਁگ܅+S\ORULઅ҆ਐઊୱઊѿ৺ؘ
ҫ੶ܾࡂৈીࣛפֳણઅࠋࣥਁؘৰؖી٩Ӛઊઔ
ؘҫ੶ܾࡂઊކીࣛפֳણઅଔരਁؘਕലઊ৺ؘ
ࣹ
+HOLFREDFWHU3\ORULਭפֳણӘઅӚӆ
Ԥ
ᖒɁš᮹ݡ
www.koreanglaucoma.org
7
9ROXPH_1XPEHU
ҫ੶ܾࡂઊઍୱહઌઌઊ܅ԞࡂدؘԞઅৰۄઌઊ
ઔڹԓസઌઅ൭Әݴࠔѿ१ౄؘઊୱહઌ൛ઌ
੶ܾઙੋഢҫઊ܅Ӌஷௐടਔد
+S\ORULѿਁਕലܱԪાԕനৡഡد+
S\ORULઘஔѿਕല߸़٩ઔކৈଓԪ+S\ORULѿ
ણઽޅઊ਼અଓਁࣳࣥഡدؘࡂӋѿ৺Ӌଓਁ
ࣳFRORQLݴઊݗӋࣔң֢HFWRSLFJDVWULFPXFRVDѿפֳણ൝ ઘઅਁથഡدؘࡂӋѿ৺ؘҫӋܱഢڹৈބ٩ԓ
ઌઊԑઘஔઊԞࡂدؘԑਁفഡധஔઅઊୱࠉઊң֢
+S\ORULܾઌഡ࡚ࡻٻؘ٪ऀߜଖઊઌઍҫ੶ܾࣥҀഡ
د1424ކৢԑઘஔѿਁਕല߸دӴઅ҆ਐӄ
ؘܾܾ“Әछઅાண”ࠃ“छӘઅાண”ӄܾݴ౿ഡଓ
ાહાணઊઔ़ઔҫઊ٪ऀߜଖઅਕലઊ܅+
S\ORUL҆ਐ൝ઘѿֳࢽؘඛӖԞਁDPPRQLD֢K\GURJHQ
F\DQLGHؘۙK\GURJHQQLWUDWHѿއઊ೩തټҧܾࡂৈઊܾ
ઌഡਕല٩ѿ؟ഢҫ੶ܾࣥҀഡدۙഡಡઊധஔѿӚ
ऀઊઔدઽޅ౿ന३േݩݴౌӋۂ٭َധധ ஔࡃഥஔѿԶଔ%ORRGRFXODUEDUULHUݴ౿നੌඥӴܾ
ടਉࠒ़ਁफ़ڝң֢३ӄଓਁਕലؘӄܾ٩
ѿ؟ഢҫઊد
د৩ഡઌઊਕലدؘפֳણઅԞӋܱനࡆڹ
+S\ORULਭઅӚऀৈބ٩ଓાહઌԑઘஔਁઅഡࡘ࡚
ࡂدઊୱહઌਕലઊًీҫ੶ܾࣥҀഡد+S\ORULԑਁ
અഡDXWRLPPXQHࠉઊ֢12ࣥऀࠉऀ࣒घڢਁઅ ഡ१३ӄਁઅଓાહઌछࣛ٩ѿ؟ടҸӋ(QGRWKHOLQ1࡚ࡻ
ݴ౿ഡളേઊ֢9DF$WR[LQڢਁઅഡDSRSWRVLV٩ѿ؟ഡԞ
ઍҫઊدۙഡSURLQIODPPDWRU\F\WRNLQHV࡚ࡻݴ౿ഡކऀ
ਐઊࠉऀ࣒घઅࣥऀணଔടӋઊݴ౿ഡR[LGDWLYH
VWUHVVઅѿѿ१३ӄਁਕല़٩ઔӋࣼ੭ਁਕല
ৰRXWIORZIDFLOLW\ݴ࠹൛१ఇࣛ०१ౄؘԞ੶
ܾઙੋഢ़٩ઔد)LJ1
ਉܟѿԞઊਕല ѿ؟ऀઊઔކ ԓૻਁࣳ٩
פֳણӘઝӚټࡘ࡚ৈބ٩࣒൛હफ़ಠܩफ़ݴѿ १ౄؘԞઊԓܢڡനࡂઌدԞઅਉܟӴਁࣳઊ߸
&KODP\GLDؘۙF\WRPHJDORYLUXV҆ਐઊࠉऀ࣒घઅࣥ
ऀ౿ഡٳޔӄ൛ࠋࣥӘӚٻৼدӋടؘڢ҆ਐ੶ܾ
Fig. 1.3RVVLEOHUHODWLRQVKLSEHWZHHQ+HOLFREDFWHUS\ORUL+3DQGJODXFRPDDQGLWVPHFKDQLVPV+RZ+3SURPRWHVJDVWULFQHRSODVLDLVQRW\HW
FRPSOHWHO\XQGHUVWRRGRQHRIWKHK\SRWKHVLVHGPHFKDQLVPVLVWKHSURGXFWLRQRIUHDFWLYHR[\JHQVSHFLHV5267KHEDFWHULDLQGXFHFKURQLF
LQIODPPDWLRQRIWKHJDVWULFPXFRVDIROORZHGE\WKHJHQHUDWLRQRIDODUJHDPRXQWRI526E\DFWLYDWHGSRO\PRUSKRQXFOHDWHG301FHOOVWKH
UHOHDVHRI&DJ$WR[LQVPD\DOVROHDGWR526SURGXFWLRQDQGWKHUHVXOWLQJR[LGDWLYHVWUHVVPD\EHDPSOLILHGE\WKHUHGXFWLRQLQDQWLR[LGDQWGHIHQFH
IDFWRUVVXFKDV*6+DVLQGXFHGE\WKHEDFWHULXPLWVHOI$QDFFXPXODWLRQRILQWUDFHOOXODU526UHJXODWHVWKHH[SUHVVLRQRIPDQ\JHQHVDQGFDQ
LQGXFHSRLQWPXWDWLRQVFRQWULEXWLQJWRWKHSDWKRJHQHVLVRIJDVWULFFDQFHU3URLQIODPPDWRU\F\WRNLQHVVXFKDVLQWHUIHURQJDPPD,1)FDQG
WXPRXUQHFURVLVIDFWRUDOSKD71)DDQG9DF$WR[LQVFDQWULJJHUDSRSWRWLFPHFKDQLVPVOHDGLQJWRRSWLFQHUYHKHDGGHJHQHUDWLRQ7KLVPD\DOVR
EHWKHUHVXOWRIWKHDXWRLPPXQHUHVSRQVHIROORZLQJWKHLQIHFWLRQRUWKHILQDOHIIHFWRIHQGRWKHOLQVDQGQLWURVDWLYHVWUHVVJHQHUDWHGE\WKHEDFWHULXP
,]]RWWLHWDO%-2
Journal of The Korean Glaucoma Society
JOURNAL OF THE KOREAN GLAUCOMA SOCIETY 8
ઌഡV\VWHPLFR[LGDWLYHGDPDJHѿࠋࣥതઊٻৰઔӋઊ ܟഡछࣛઊކऀ಄രऀଖ൝અസઌઊ֢१ࠋઽઊٽ़
ઔدؘӴڝઊࠋٻৰدࣛ०ઊ֢ളേਊࠉ
ڢ౿ഡ࣒൛હछࣛઊפֳણࠋࣥઅഡӄܾܾઊനٻڡ
+S\ORUL҆ਐ౿ഡ࣒൛હफ़ಠܩफ़અѿѿٳઍടҲ
സઌ੶ܾઙੋഢ़٩ઔҫઊد
결 론
+S\ORUL҆ਐઊ൜५ഡസઌ੶ܾӋܱٻܱৈଓއ
ӴѿًചടدಡඥৈଓԪفԐSRSXODWLRQEDVHG
VWXG\ѿٻৰઔৌӋஔઌӴૻ+S\ORUL҆ਐઘѿפֳ
ણ൝ઘࡂدർূއ੶ڂଖ࠾ਁӚऀઊઔدԓҫઊ
ԑઘஔਁઅഡਕലઌࡘ࣒ߜઊ֢࡚ࡻٻؘਉܟߜଖਁઅ ഡਕലઌѿ࡚ടدۙഡ+S\ORUL҆ਐઊפֳણઅ
ઌઊٻܱԑૂңയڹ१ৡҩ࣏֢ڢפֳણઅ
ڝઅઊઔৰৡട֢ৈଓԪԓܡࡘ࡚࡚ടҲന ҿനؘࡂӋؘ৺دԓݼӋפֳણਁࣥԞؘ࠾ઊ
+S\ORULઅਕല३ਁ߸ௗؘ࠾ઊدಡඥ৩פֳણઊ
१Ԟહ੶ܾࡻ॥ടҲਠৌ़٩ઔӋפֳણઅVHYHULW\
٩৩અୱઊѿిӄੌѿއҫӋܱനࡂ३ଖ൝ અङऀѿؘଖ࠾ઊӵघહଖ࠾ઌפֳણઅࠋؘࣥۙଔ രਁ߸ௗؘਕലઊૂഡહઍ़ࠇਁ৺ҫઊدৈބ٩Ӛ
ऀઊઔدଓાહઌઌઊ܅ԞࡂدؘԞઅઌઊઔڹ
ԓ൭Әݴ೪१ౄؘઊୱહઌ൛ઌ੶ܾਊഢഢҫ੶
ܾࣥҀഡدৈଓԪؘפֳણઅއѿࣹૻૂ१ټۙട
֢અѿࣹહઌ़ਁޡߜܟઔ੶ৗ੶ܾڂଖ࠾ҁઅ
ӚऀਁفഡനއӴѿًଔരٻৰৡഢҫઊ د
참고문헌
1. Ahnoux-Zabsonre A, Quaranta M, Mauget-Faÿsse M.
Prevalence of Helicobacter pylori in central serous chorioretinopathy and diffuse retinal epitheliopathy: a complementary study. J Fr Ophtalmol 2004;27:1129-33.
2. Apan TZ, Gürsel R, Dolgun A. Increased seropositivity of Helicobacter pylori cytotoxin-associated gene-A in Be- hçet’s disease. Clin Rheumatol 2007;26:885-9.
3. Choi CY, Kim MS, Kim JM, et al. Association between Helicobacter pylori infection and Posner-Schlossman
syndrome. Eye (Lond) 2010;24:64-9.
4. Chung HS, Harris A, Evans DW, et al. Vascular aspects in the pathophysiology of glaucomatous optic neuropathy.
Surv of ophthalmology 1999;43:S43-50.
5. Flammer J, Haefliger IO, Orgül S, Resink T. Vascular dys- regulation: a principal risk factor for glaucomatous dam- age? J Glaucoma 1999;8:212-9.
6. Galloway PH, Warner SJ, Morshed MG, Mikelberg FS.
Helicobacter pylori infection and the risk for open-angle glaucoma. Ophthalmology 2003;110:922-5.
7. Hong Y, et al. Relationship between Helicobacter pylori infection and open angle glaucoma in China. Asian J Ophthalmol 2007;9:205–8.
8. Hosseini H, Ghaffariyeh A, Nikandish R. Noxious com- pounds in exhaled air, a potential cause for ocular mani- festations of H. pylori gastrointestinal infection. Med Hypotheses 2007;68:91-3.
9. Izzotti A, Saccà SC, Bagnis A, Recupero SM. Glaucoma and Helicobacter pylori infection: correlations and con- troversies. Br J Ophthalmol 2009;93:1420-7.
10. Izzotti A, De Flora S, Cartiglia C, et al. Interplay between Helicobacter pylori and host gene polymorphisms in inducing oxidative DNA damage in the gastric mucosa.
Carcinogenesis 2007;28:892-8.
11. Kim JM, Kim SH, Park KH, et al. Investigation of the association between Helicobacter pylori infection and normal tension glaucoma. Invest Ophthalmol Vis Sci 2011;52:665-8.
12. Kim JM, Park KH, Choi MJ, et al. The effects of Helico- bacter pylori infection on intraocular pressure in anterior uveitis. Eye (Lond) 2012;26:1503-9; quiz 1510.
13. Kim JM, Kim YJ, Kim DM. Increased expression of oxy- proteins in the optic nerve head of an in vivo model of optic nerve ischemia. BMC Ophthalmol 2012;12:63.
14. Knox DL. Glaucomatocyclitic crises and systemic disease:
peptic ulcer, other gastrointestinal disorders, allergy and stress. Trans Am Ophthalmol Soc 1988;86:473-95.
15. Kountouras J, Mylopoulos N, Boura P, et al. Relationship between Helicobacter pylori infection and glaucoma.
Ophthalmology 2001;108:599-604.
16. Kountouras J, Mylopoulos N, Chatzopoulos D, et al.
www.koreanglaucoma.org
9
9ROXPH_1XPEHU
Eradication of Helicobacter pylori may be beneficial in the management of chronic open-angle glaucoma. Arch Intern Med 2002;162:1237-44.
17. Kountouras J, Mylopoulos N, Konstas AG, et al. Increased levels of Helicobacter pylori IgG antibodies in aqueous humor of patients with primary open-angle and exfo- liation glaucoma. Graefes Arch Clin Exp Ophthalmol 2003;241:884-90.
18. Kountouras J, Tsolaki M, Gavalas E, et al. Relationship between Helicobacter pylori infection and Alzheimer disease. Neurology 2006;66:938-40.
19. Liu R, Moroi M, Yamamoto M, et al. Presence and se- verity of Chlamydia pneumoniae and Cytomegalovirus infection in coronary plaques are associated with acute coronary syndromes. Int Heart J 2006;47:511-9.
20. Mielants H, Veys EM, Cuvelier C, De Vos M. Course
of gut inflammation in spondylarthropathies and therapeutic consequences. Baillieres Clin Rheumatol 1996;10:147-64.
21. Naito Y, Yoshikawa T. Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress. Free Radic Biol Med 2002;33:323- 36.
22. Otasevic L, Walduck A, Meyer TF, et al. Helicobacter py- lori infection in anterior uveitis. Infection 2005;33:82-5.
23. Saccà SC, Pascotto A, Venturino GM, et al. Prevalence and treatment of Helicobacter pylori in patients with blepharitis. Invest Ophthalmol Vis Sci 2006;47:501-8.
24. Saccà SC, Izzotti A, Rossi P, Traverso C. Glaucomatous outflow pathway and oxidative stress. Exp Eye Res 2007;84:389-99.