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AKAP12 Supports Blood-Brain Barrier Integrity against Ischemic Stroke

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Figure 1. AKAP12 expression after stroke: (a) Double-staining of AKAP12 (red) with an endothelial  marker  CD31  (green)  showed  that  AKAP12  was  expressed  in  or  around  blood  vessels,  and  its  expression  level  transiently  increased  after  str
Figure 3. AKAP12 and in vitro endothelial permeability: (a) In cultured cerebral endothelial cells,  two kinds of Akap12 siRNAs (siRNA#1 and siRNA#2) suppressed AKAP12 expression
Figure 4. Rho kinase and in vitro endothelial permeability: (a) In cultured cerebral endothelial cells, Akap12 siRNAs (siRNA#1 and siRNA#2) activated the Rho kinase pathway
Figure 6. AKAP12 and endothelial viability: Akap12 KO mice exhibited more ssDNA-positive CD31  cells  (damaged  endothelial  cells)  after  stroke

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