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Growth Hormone-Releaser Diet Attenuates Cognitive Dysfunction in Klotho Mutant Mice via Insulin-Like Growth Factor-1 Receptor Activation in a Genetic Aging Model

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Fig. 1. Experimental schedule for evaluating the effect of a  growth hormone (GH)-releaser diet on the cognitive dysfunction  in klotho mutant mice
Fig. 2. Effect of a growth hormone (GH)-releaser diet on the  mRNA expression of insulin-like growth factor-1 (IGF-1) and  IGF-1 receptor in the hippocampus of klotho mutant mice
Fig. 3. Effect of JB-1, an insulin-like growth factor-1 (IGF-1) re- re-ceptor antagonist, on the growth hormone (GH)-releaser  diet-me-diated attenuation of changes in the expression of (A)  phospho-Akt (p-phospho-Akt), (B) phospho-glycogen synthase kinase
Fig. 6. Effect of JB-1, an insulin-like growth factor-1 (IGF-1) receptor antagonist, on the growth hormone (GH)-releaser diet-mediated  attenuation of lipid peroxidation, as measured by (A) the malondialdehyde (MDA) level, and protein oxidation, as measure

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