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Cardiovascular Risk Factors: It's Time to Focus on Variability!

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Fig. 1. LDL-C and BP variability and outcome. Compared to the group with low variability for LDL-C and SBP, the high variability group had a significant increase  in any coronary event (HR adj , 1.48; 95% CI, 1.30–1.70; p<0.05) and fatal or non-fatal MI
Fig. 2. LDL-C variability and outcome. Visit-to-visit LDL-C variability was defined as between visit variability in  LDL-C values of the 9,572 patients in the TNT trial
Fig. 3. Body weight variability and rates of coronary and cardiovascular events. A coronary event was defined as a composite of death from coronary heart  disease, nonfatal myocardial infarction, resuscitated cardiac arrest, revascularization, or angina

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