A case report of monitoring PSA level changes in two prostate cancer patients treated with Mountain Ginseng Pharmacopuncture and Sweet Bee Venom along with western anticancer therapy

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A case report of monitoring PSA level changes in two prostate cancer patients treated with Mountain Ginseng Pharmacopuncture and Sweet

Bee Venom along with western anticancer therapy

Yeonhee Lee, Chaewon Kim, Kwangho Lee

Department of Acupuncture & Moxibustion, Oriental Medicine Hospital of Sangji University, Wonju, Korea

KEY WORDS:

Prostate cancer;

Mountain Ginseng Pharmacopuncture;

Sweet Bee Venom;

Prostate specific antigen Received : Nov 10, 2011 Revised : Nov 23, 2011 Accepted : Nov 29, 2011

I

. 서론

2008

7 Prostate specific

antigen PSA Abstract

Objectives: The purpose of this report is to find out how Mountain Ginseng Pharmacopuncture(MGP) and Sweet Bee Venom(SBV) treatments are effective on prostate cancer patients by monitoring Prostate specific antigen(PSA) values.

Methods: We treated two prostate cancer patients with MGP and SBV from October 2008 to April 2011. One patient had localized prostate cancer, the other was in the terminal stage of prostate cancer with lung and bone metastasis and both had been receiving western anticancer therapy. We had moni- tored the changes of PSA value.

Results: In case 1, MGP and SBV treatments seemed to be helpful in preventing the recurrence of localized prostate cancer. In case 2, PSA value was decreased by MGP treatment.

Conclusions: It is conceivable that MGP and SBV are effective treatments for patients with prostate cancer.

Case Report

양방 항암치료와 병행하여 산삼약침과 봉약침 치료를 받은 전립선암 환자들의 PSA 수치 변화 관찰 보고

2011 Korean Pharmacopuncture institute http://pharmacopuncture.co.kr

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://cre- ativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non- commercial use, distribution, and reproduction in any medium, provid- ed the original work is properly cited.

Corresponding Author

Kwangho Lee. Department of Acupuncture & Moxibustion, Oriental Medicine Hospital of Sangji University, 283 Woosan-dong, 220-955 Wonju, Korea.

Tel: +82-33-741-9257 E-mail: [email protected] cc

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II

. 대상 및 방법

1

2008 10 2011 4

2

2.1

20mL 20mL/ 1 3

2.2

(G²¹) (G²⁰) 0.2 cc BUM (CV¹⁷) 0.2 cc, Sweet Bee Venom SBV (CV¹²) (CV⁶)

0.3 cc

2.3

SBV (LI⁴) (Liv³) (S³⁶) 0.1cc

(CV³) (Sp⁶)

(CV¹) SBV 0.1 cc

2.4

2.4.1

(K¹⁰) (Liv⁸) (L⁸), (Liv⁴)

2.4.2

III

. 증례 1.

1.1 (M/51)

1.2 Prostate Adenocarcinoma (T3bN0M0 ) (Gleason's score 4+4=8/10, tumor area:

80%)

1.3 2008 8

1.4 2008 10

1.5

1.6

1.7

A B

B

1.8 (Table 1, Fig. 1)

1.8.1 2008 8 8 A

B 8

3

1.8.2 2008 8 PSA 29.59ng/mL cancer volume 27cc

T3bN0M0

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2

1.8.4 2008 10 PSA 1.38ng/mL

1.8.5 2008 11 PSA 0.73ng/mL

1.8.6 2008 12 PSA 0.40ng/mL

1.8.7 2009 1 PSA 0.30ng/mL

1.8.8 2009 2 PSA 0.17ng/mL

1.8.9 2009 4 PSA 0.09ng/mL

prostate volume 14cc

apex

T3bN0M0

1.8.10 2010 2 PSA 0.04 ng/mL

1.8.11 2010 3 PSA

1.8.12 2010 4 prostate volume 8cc cancerous lesion

T0N0M0

1.8.13 2010 5 PSA 0.02ng/mL

1.8.14 2010 8 PSA 0.01ng/mL

1.8.15 2011 4 PSA 0.01ng/mL

2 B

2

2.1 (M/53)

2.2 Prostate cancer with bone, lung meta(T3bN0M1c), (Gleason's score 3+5=8/10)

2.3 2009 6

2.4 2009 10

2.5

2008. 08 2008. 10 2008. 11 2008. 12 2009. 01 2009. 02 2009. 04 2010. 02 2010. 05 2010. 08 2011. 02

29.59 1.38 0.73 0.40 0.30 0.17 0.09 0.04 0.02 0.01 0.01

PSA Hormone^* Radiation MGP SBV Table 1. Changes of PSA Values in Case 1.

* Hormone Therapy. Injection once every 3 months, tablet daily.

External beam radiation therapy

Mountain Ginseng Pharmacopuncture treatment Sweet Bee Venom treatment

Fig. 1. Prostate MRI of Case 1: A. Extensive prostate cancer with extracapsular extension and seminal vesi- cle invasion. B. No demonstrable recurrent cancer in the prostate and no evidence of lympadenopathy or bony metastasis.

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2.6 2004 C

1

2.7 2009 3

2009 6 C

chest CT

2.8 (Table 2, Fig. 2)

2.8.1 2009 6 (T4N0M2)

2.8.2 2009 7 D T3bN0M1b

PSA 555ng/mL (Zoladex LA Depot) (Casodex tab(50mg))

2.8.3 2009 8 Bone Scan 7 20 C both pelvic

2.8.4 2009 9 PSA 192ng/mL

marking 2009 7

2.8.5 2009 10

2009. 07 2009. 09 2009. 10 2009. 11 2010. 02 2010. 05 2010. 08 2010. 11 2011. 01 2011. 02 2011. 03 2011. 04

555 192 41.1 9.8 4.7 3.9 6.1 67.9 12.8 11.3 13.5 23.6 PSA

Table 2. Changes of PSA Values in Case 2.

* Zoladex depot injection, once every 3 months.

Casodex tablet 50mg Androcur tablet 50mg

Estracyt capsules 140mg

Mountain Ginseng Pharmacopuncture treatment Sweet Bee Venom treatment

1

1 1 1 1 1

Zoladex^* Casode Andr-

ocur Estracyt MGP SBV

Fig. 2. Bone Scan of Case 2: A. October 2009. There were Disseminated bone metastasis on both pelvic bone, skull, multiple ribs, scapulae, multiple spines. B.

May 2010. Slightly improved disseminated bone metastasis, since October 2009. C. March 2011.

Slightly aggravation of disseminated bone metastasis, since May 2010. D. May 2011. No interval change of disseminated bone metastasis, since March 2011.

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2.8.6 2009 10 PSA 41.1ng/mL

2.8.7 2009 10 Chest

Bone scan

2.8.8 2009 11 bone-

IV

. 고찰

1999 1,437

2008 6,471 14.9%

2

(Prostate specific antigen, PSA) (transrectal ultrasonography)

(needle biopsy)

4.0ng/mL PSA

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100%

PSA 3

PSA 10ng/mL

10ng/mL ~ 20ng/mL 20ng/mL

2/3

2.5-3.2

Gleason TNM

12

1-2

115%

doxorubicin

1

PSA 29.59

PSA prostate volume

2 PSA 555

PSA

(Fig. 2)

12

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V

. 결론

2008 10 2011 4

2

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