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Can antioxidants be effective therapeutics for type 2 diabetes?

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Fig. 1. Intracellular reactive oxygen species (ROS) generation and the antioxidant scavenging system
Fig. 3.  Inhibition of the insulin signaling pathway by oxidative stress. Reactive oxygen species (ROS) interferes with insulin action by  altering several substrates of the insulin signaling pathway
Table 1. The effect of deficiency or overexpression of antioxidant enzymes on glucose metabolism and insulin sensitivity in mice
Table 2. Recruiting and not yet recruiting (August 2020) clinical trials of agents with antioxidant properties targeting type 2 diabetes

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