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The Blood-Brain Barrier Permeability and Pharmacokinetics of Nitrone Based Spin Trapping Agent, α-Phenyl-n-tert-Butyl Nitrone (PBN) in Rats

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Academic year: 2021

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Fig.  1 - Chemical  structure  of PBN  used  in  the  present  study.
Fig.  2  -  Typical  chrom atogram s from  H P L C   injection o f injectate  (A),  brain extract obtained at 0.25  m in  after internal carotid artery perfusion  (B),  brain  extract  obtained  at  120  m in   after  intravenous  injection  (C)  of  P B N
Table II - The blood-brain barrier permeability of PBN using ICAP  method

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