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― S-181 ― Incidence and outcome of constrictive physiology after coronary artery bypass graft surgery

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― S-181 ―

Incidence and outcome of constrictive physiology after coronary artery bypass graft surgery

연세의대 신촌세브란스병원

*임 의․이승율․장양수․정남식․심원흠․조승연․하종원

Background : Constrictive pericarditis (CP) is not an uncommon cause of heart failure after coronary artery bypass grafting (CABG) despite preserved left ventricular systolic function. However, clinically, it is frequently unrecognized and spontaneously resolved unlike CP due to traditional etiologies. Few data are available regarding the incidence and fate of CP after CABG. The objective of this study is to investigate the incidence and clinical course of CP after CABG. Methods : From January 2004 through September 2006, 551 patients underwent CABG with or without valve surgery. Their medical records and echocardiographic data were reviewed. Diagnosis of CP was based on transthoracic echocardiography (TTE). Results : Total 86 of 551 patients (16%) showed CP after CABG. Their baseline characteristics were not different from patients without CP except higher incidence of smoking (55 vs 42%, p=0.035) and lower incidence of CABG with valve surgery (9 vs 18%, p=0.050).

Left ventricular ejection fraction (59 vs 54%, p=0.009) and the presence of pericardial effusion (36 vs 23%, p=0.010) after CABG was higher in patients with CP. Their frequency of dyspnea (13 vs 10%, p=0.456), chest pain (3 vs 1%, p=0.153), peripheral edema (5 vs 3%, p=0.293) and fever (1 vs 2%, p=1.000) after CABG were not significantly higher compared to patients without CP. Follow up TTE was done in 60 of 86 patients (70%) with CP. Of them, 49 patients (82%) showed resolution of CP at mean 453±343 (9-1289) days after CABG. Only 1 of 11 patients (9%) with residual CP re-admitted for CP and improved medically.

Conclusion : CP after CABG has resolved in most patients and aggravation to permanent CP was rare. Therefore, for the management of CP after CABG, conservative follow-up without surgical intervention may be warranted. Key words : constrictive physiology, coronary artery bypass grafting

― S-182 ―

Streptococcus anginosus에 의한 감염성 심내막염 1예

아주대학교 의과대학 순환기내과학교실

*김진우․서경우․임남규․우성일․임홍석․최병주

Streptococcus angionosus는 S. constellatus, S. intermedius와 함께 Streptococcus milleri group에 속하며 viridans streptococcus양 균주라고 일컬어지기도 한다. 점막의 정상 상재균으로 존재하며 화농성 변화와 농양의 형성, 혼합감염이 특징적이다. S. anginosus 는 감염성 심내막염의 드문 원인 균주이며 임상 경과 및 치료가 잘 알려져 있지 않다. S. anginosus에 의한 감염성 심내막염은 화농 성 합병증이 흔하며 viridans streptococcus보다 사망률이 높아 여러 외국 문헌에서 그 중요성이 보고된 바 있다. 저자는 아직 국내 에 보고된 증례가 없는 S. anginosus에 의한 감염성 심내막염 1예를 경험하여 보고하는 바이다. 29세 남자가 3주간의 근육통을 동반 한 간헐적인 발열과 오한을 주소로 입원하였다. 환자는 기흉으로 치료 받은 적 있으며 그 외 정맥 주사 및 치과 치료의 과거력 없었 다. 내원 당시 체온은 37.5도 였으며 심첨부에서 범수축기 심잡음이 청진되었다. 입원 당시 시행한 심초음파에서 승모판 전엽에 1.4cm x 0.5cm의 증식과 함께 중증의 승모판 역류가 동반되었다. 아급성 감염성 심내막염 의심하에 ampicillin과 gentamicin의 병합 요법으로 경험적 치료를 시작하였고 입원 8일째 혈액 배양 검사에서 penicillin 감수성 균인 S. anginosus가 동정되어 gentamicin 2주를 포함한 총 4주동안 항생제 유지 후 치료를 종료하였다. 배양된 Streptococci는 phenotypic method인 Vitek System(GPI)에 의해 S. anginosus로 분류되었다. 입원 5일째 시행한 경식도 초음파에서 증식증과 함께 승모판 후엽의 일탈에 의한 중증의 역류증 소견보였으며 판막 주위 농양은 관찰되지 않았고, 입원 20일째 시행한 경흉부 심초음파상 증식의 크기가 0.6cm으로 감소되었다. 환 자는 현재 증상없이 Angiotensin-converting enzyme inhibitor 유지하여 외래 추적관찰 중이다.

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