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Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in

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Academic year: 2021

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Fig.  1.  Domain  structure  of  PEA-15.  PEA-15  protein  contains  an  N-terminal  death  effector  domain  (DED)  domain
Fig. 3. Knockdown of PEA-15 induced nuclear translocation of pErk1/2. (A) TPA induced  phosphorylation of PEA-15 at S 104  residue
Fig. 5. Progression of G1 to S phase by either TPA treatment or knockdown of PEA-15 in  HDF senescent cells
Fig. 6. Increase of cell proliferation by either knockdown of PEA-15 or TPA treatment
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