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Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells

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Figure  1.  Chemical  structure  of  Compound  K,  [20-O- D -glucopyranosyl-20(S)- -glucopyranosyl-20(S)-protopanaxadiol]
Figure 2. Cytotoxic effect of Compound K in human colon cells. Cell viability  (A) at the  indicated concentrations of Compound K at 48 h in HT-29 cancer cells; (B) at the indicated  times with Compound K at 20 μg/mL in HT-29 cells; (C) at 20 μg/mL of Comp
Figure  3.  Intracellular  ROS  generation  induced  by  Compound  K  treatment.    (A)  Intracellular  ROS  generated  by  Compound  K  were  detected  at  indicated  times  by  a  spectrofluorometer  after  DCF-DA  treatment
Figure  4.  Induction  of  mitochondria-dependent  and  caspase-dependent  apoptosis  by  Compound K treatment
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