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Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X7 receptors

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FIGURE 1. Extracellular ATP induced SN4741 dopaminergic cell volume increase. A, concentration-de- concentration-de-pendent response of ATP-induced volume increase in SN4741 cells
FIGURE 2. Extracellular ATP induced necrosis in SN4741 dopaminergic neurons. Concentration-dependent response of ATP-induced cell death in SN4741 cells is shown
FIGURE 4. Antagonist of P2X 7 Rs blocks ATP-induced volume increase and cell death. A, the ATP-induced volume increase was blocked by KN-62.
FIGURE 5. Suppression of endogenous P2X 7 Rs expression attenuated ATP-induced cell death and vol- vol-ume increase

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