Association between allergy and cancer in Korean adults

310

￭ ^♣ S-537 ￭

Association between allergy and cancer in Korean adults

1Department of Internal Medicine, Seoul National University College of Medicine, ²Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, ³Department of Internal Medicine, Seoul National University Bundang Hospital, ⁴Healthcare System Gangnam Center, Seoul National University Hospital, ⁵Seoul National

University College of Medicine

*Byung-Soo Kang

, So-Hee Lee

, Tae-Whan Kim

, Hye-Ryun Kang

, Sae-Hoon Kim

, Heung-Woo Park

, Yoon-Seok Chang

, Sun-Sin Kim

, Kyung-Up Min

, Sang-Heon Cho

Background: Neumerous epidemiological studies have evaluated the association between allergy and cancer occurrence and It has been a debate that whether allergy is a risk factor of protective factor for cancer. However, no study has been conducted among Koreans. Objective: To evaluate the association between cancer and atopy, airwary hyperresponsiveness or allergy in Korean general population. Methods: A retrospective review of subjects who visited the Seoul National University Hospital Gangnam Healthcare Center from October 2003 to May 2011 was done. Atopy was defined if a subject had a positive result on skin prick test or in vitro allergen specific IgE tests. Airway hyperresponsiveness (AHR) was defined when PC20 was less than 25 mg/dL in methacholine bronchial provocation test (MBPT). Information on cancers was obtained from medical history, endoscopic or ultrasonography-guided biopsy, and imaging studies such as computed tomography or magnetic resonance imaging. Results: Among 12479 subjects, 498 subjects had atopy, 546 had AHR, 920 (7.4%) had allergic diseases and 326 (2.6%) cases of cancer occurred. 13 atopic individuals (p=0.818 compared with non-atopics) and 19 subjects with AHR (p=0.262 compared with subjects without AHR) had cancer. Patients with allergic rhinitis had slightly more cancer compared with individuals without allergic rhinitis (p=0.044) and there is no significance in other allergic diseases. Conclusion: We observed a small increased incidence of cancer in allergic rhinitis patients. Further investigation is warranted to confirm these associations.

￭ ^♣ S-538 ￭

Serum vitamin D levels in patients with obstructive airway diseases in real clinical practice

Department of Internal Medicine, College of Medicine, Dong-A University, Busan, Korea

*Mi-Ran Park, Il-Hwan Jeong, Su-Min Park, Sung-Woo Lee, Neul-Bom Yoon, Soo-Jung Um, Soo-Keol Lee, Choon-Hee Son

Background and objective: Some published data suggest that 25(OH) vitamin D (vitamin D) may participate in the airway inflammation of obstructive airway diseases. This study was performed to evaluate the relationship between serum vitamin D levels and lung functions in patients with obstructive airway disease including COPD and bronchial asthma in real clinical practice. Methods: COPD was defined by pulmonary function, FEV1/FVC of ≤ 70 % and FEV1 of ≤ 80% of predicted value. Bronchial asthma was diagnosed by positive airway hyperresponsiveness or bronchodilator responsiveness. Serum vitamin D was measured by chemoluminescence immunoassay. All values are expressed as mean± SD. Results; 29 patients (48.3%) were compatible with COPD, vitamin D level were 25.83±13.06 ng/ml and 31 patients (51.7%) were compatible with bronchial asthma, their vitamin D level were 35.47±31.19 ng/ml. However, there was no significant difference in serum vitamin D levels between two groups (p>0.05). Vitamin D insufficiency (≤ 20 mg/ml) was observed in 10 patients (34.48%) of COPD and 10 patients (32.35%) of asthma (p>0.05). COPD with reversible component in pulmonary function was demonstrated in 6 patients (10.9%), their mean vitamin D level was 29.73±13.57 ng/ml. There was no significant difference in the serum level of vitamin D between copd with or without reversible airway obstruction (p>0.05) Serum vitamin D level and lung function showed some trend of positive correlation, however, we could not find statistical significance (r=0.18, p>0.05) Conclusions: Reduced vitamin D levels seem to be associated with impaired lung function. Further studies are required to evaluate the relationship between reduced vitamin D level and impaired lung function in patients with obstructive airway diseases. Key Words; Vitamin D, Pumonary disease, Chronic obstructive, Asthma