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Primary transitional cell carcinomas are more aggressive than malignant Brenner tumor

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(1)

Brenner 1-3 Brenner

(subtype) .4-6

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.7-9 38

1 .

, 38 ,

2001 12 18

14 , 30

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. 2

Department of Obstetrics and Gynecology, Pathology, Dankook University College of Medicine, Cheonan, Korea

Primary transitional cell carcinoma of the ovary has been only recently recognized, as one of the main types of ovarian carcinoma because of the favorable response to chemotherapy and improved survival of the patient. Histologically, it is distinguished from malignant Brenner tumor only in the absence of benign or proliferative Brenner tumor component.

Recent histopathologic reports show that transitional cell carcinoma of the bladder and of the ovary are immunophenotypically different. Primary transitional cell carcinomas are more aggressive than malignant Brenner tumor.

However, primary transitional cell carcinomas have a better response to chemotherapy than other types of ovarian carcinomas.

We have experienced a very rare case of primary papillary transitional cell carcinoma of the left ovary in a 38-year-old woman and report it with review of literatures.

Key Words : Ovary, Papillary transitional cell carcinoma

(2)

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, 165 cm, 64 kg, 130/80 mmHg,

90/min, 24/min , 37.0

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dl, 37%, 7,240/mm3,

336,000/mm3, HBsAg , HBsAb , VDRL

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, , , X

EKG .

CA-125 128.77 U/ml

CEA CA 19-9 8.69 ng/ml, 1.50

U/ml . 7×4×3

cm , 6.2×8.2 cm

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cm (lobulated margin)

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, . , . transitional cell carcinoma

tumor cell nest .

,

serous carcinoma .

(Fig. 4).

,

transitional cell carcinoma (Fig. 5).

,

. 4

, (Cisplatin)

13

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Taxol-Carboplatin

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2003 1 7.22 U/ml , 2002

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cell carcinoma)

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1% .6

Brenner , ,

1987 Austin Norris4 Brenner

.5 Brenner

Brenner

Brenner grade 2 3

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. Silva 6 M. D. Anderson

10 Mexico

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1 .

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(chromatin) 2

3 .

.

Wick 16 1985

.

. . Ordonez17

.

(urothelium) (surface

glycoprotein) thrombomodulin (TM) cytokine 20, carcinoembryonic antigen (CEA)

TM cytokine 20

CEA 13

TM cytokine 20

CEA 2

.

.

Brenner , ,

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Austin Norris4

. Brenner

.

(5)

.4

hexamethylmelamine-doxorubicin-cyclophosphamide, mephalan-cisplatin, mephalan, cisplatin-doxorubicin- cyclophosphamide, hexamethylmelamine, doxorubicin, cisplatin-cyclophosphamide .3 Maluf Bajorin18

CISCA (cyclophosphamide, doxorubicin, and cisplatin), CMV (cisplatin, methotrexate, and vinblastine), M-VAC (methotrexate, vinblastine, doxorubicin, and cisplatin) , docetaxel, paclitaxel, gemcitabine, ifosfamide

. Sweeten 19

(refractory transitional cell carcinoma) (salvage chemotherapy)

.

.

, (endometrioid)

.5,6 Gershenson 7 Sweeten 19

. Silva

6

. Robey 5 1989 9

7

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. 1992 Martin 20

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. (disseminated carcinomatosis)

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