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Serum Cystatin C Is a Major Predictor of Vancomycin Clearance in a Population Pharmacokinetic Analysis of Patients with Normal Serum Creatinine Concentrations

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Table 2. Parameter estimates and bootstrap analysis of the final model Parameters* Estimate (RSE † ) Median (95% CI) by Bootstrap ‡ CL POP  (L/h) §  4.90 (1.5%) 4.90 (4.77-5.05) V POP  (L) §  46.2 (1.6%) 46.2 (44.9-47.7) θ CLage -0.00420 (18.2%) -0.00427 (
Fig. 1. Goodness of fit evaluated by the plots of (A) population prediction versus observed vancomycin concentration (mg/L) and (B) individual prediction versus observed van- van-comycin concentration (mg/L)
graphic factors together, our model could predict a wider range  of trough concentrations of 0.4-85.2 (213-fold) in representative  cases of high- or low-CL patients as expected.

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