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Underestimation of the Calculated Area Under the Concentration-Time Curve Based on Serum Creatinine for Vancomycin Dosing

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Table 1.  Demographic characteristics and pharmacokinetic parameters  of the patients
Table 2. Comparison of the calculated AUC 24  (cAUC 24 ) with 24-hour steady-state AUC (ssAUC 24 ) according to age, BMI, and the trough concentration of  vancomycin Group Number (%) cAUC 24  (mg·hr/L)[Median (IQR)] ssAUC 24  (mg·hr/L)
Figure 2. Probability (%) of reaching target ssAUC 24 /MIC (A) and cAUC 24 /MIC (B) values of 400 or higher for different MICs (0.5, 1.0, and 2.0 mg/L) and  daily vancomycin doses (2,000, 2,500, 3,000, 3,500, and 4,000 mg) by simulation in patients with a

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