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Hypoxia Activates Toll-like Receptor 4 Signaling in Primary Mouse Hepatocytes Through the Receptor Clustering within Lipid Rafts

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Fig. 1. Hypoxia causes TLR4/MD2 complex translocation to lipid rafts associated with CD14
Fig. 1. Continued.
Fig. 2. Disruption of lipid raft layer blocks hypoxia induced TLR4/
Fig. 4. The TLR4/MD2 complex translocation is ROS dependent signaling. (A) Hepatocytes were treated with H2O2 in concentration from 50∼500μM for 1 or 6 hours and subjected to discontinuous sucrose density gradient centrifugation as described in materials a

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