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20-O-(β-D-glucopyranosyl)-20(S)-protopanaxadiol induces apoptosis via induction of endoplasmic reticulum stress in human colon cancer cells

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Figure 1. Chemical structure of Compound K and induction of apoptosis by  Compound K. (A) The chemical name for Compound K is  20-O-D-gluco-pyranosyl-20(S)-protopanaxadiol. (B) DNA fragmentation was quantified  using an ELISA kit and (C) the apoptotic sub-
Figure 2. Compound K enhanced cytosolic and mitochondrial Ca 2+  overloading and ER staining
Figure 4. Downregulation of CHOP attenuated Compound K-induced apoptosis. Cells were transfected with siCHOP RNA or siControl RNA after treatment  with Compound K for 48 h, (A) DNA fragmentation was quantified using an ELISA kit and (B) the apoptotic sub-G

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