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Hypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1

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Fig. 1 Hypothermia reduces ischemic infarct volume in MCAO rats. a, An illustration of the experimental schedule
Fig. 2 Hypothermia restores HMGB1 immunoreactivity in post-ischemic MCAO rat brains. a, Representative immunohistochemistry results from MCAO-treated rat brains in the absence or presence of hypothermia
Fig. 3 Hypothermia reduces serum HMGB1 levels in MCAO rats. ELISA assay for HMGB1 performed on sera drawn from rats 4 h after sham or MCAO surgery in the absence or presence of hypothermia
Fig. 4 Hypothermia reverses the decrease in NeuN/HMGB1-double positive cells in MCAO rat brains
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