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Accelerated lactate dehydrogenase activity potentiates osteoclastogenesis via NFATc1 signaling

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Fig 1. Increased glycolytic metabolism during osteoclast differentiation. Osteoclast precursors were cultured with M-CSF (30 ng/ml) and RANKL (100 ng/ml) for the indicated times
Fig 2. Changes in LDH gene expression and isotypes during osteoclast differentiation. Osteoclast precursors were cultured in the presence of M-CSF (30 ng/ml) and RANKL (100 ng/ml) for 4 days
Fig 3. Decreased osteoclast formation by LDH-A or LDH-B depletion. Osteoclast precursors were infected with shRNA lentiviral particles targeting mouse LDH-A, LDH-B, or pLKO.1-puro empty control virus particles
Fig 4. Altered osteoclastogenic signaling during osteoclast differentiation of LDH-A or LDH-B-deficient cells
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