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Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts

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Figure 1. Effects of guggulsterone on the survival of HT-29 colon cancer cells.  Exponentially growing cells were treated with various concentrations of  guggulsterone (0-50 μM) for 24, 48, and 72 h
Figure 2. Guggulsterone induces morphologic changes in colon cancer cells,  but has no effect on intestinal epithelial cells
Figure 3. Guggulsterone reduces the protein levels of total caspase-9,  increases the levels of caspase-3, and inhibits the protein levels of cIAP-1,  cIAP-2, t-Bid, and Bcl-2 in HT-29 cells
Figure 4. Guggulsterone increases the protein levels of Fas, p-JNK, p-c-Jun,
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