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Protease and protease-activated receptor-2 signaling in the pathogenesis of atopic dermatitis

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Table 1. Serine Proteases and Their Inhibitor in Skin
Fig. 1. Role of serine proteases in the epidermal permeability barrier homeostasis. aSMase, acid sphingomyelinase;  β-GlcCer’ase, β- β-glucocerebrosidase; CDSN, corneodesmosin; DSC, desmocollin; DSG, desmoglein; KLK, kallikrein; LB, lamellar body; PAR-2, p
Fig. 2. Role of PAR-2 in the epidermal permeability barrier homeostasis. LB, lamellar body; PAR-2, protease-activated receptor-2
Fig. 3. PAR-2 and Netherton syndrome. Ela-2, pancreatic elastase-2; KLK, kallikrein; LETKI, lympho-epithelial Kazal-type-related inhibitor; PAR-2, protease-activated receptor-2; SPINK-5, serine protease inhibitor kazal-type 5; TSLP, thymic stromal lymphopo
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