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The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is Phosphatase and Tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway

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Figure 4. Oxidation of PTEN and recovery of PTEN activity from oxidative inactivated PTEN in the cells stimulated either insulin or H 2 O 2
Figure 5. Analyses of the phosphorylation status of PTEN. Cells were stimulated with insulin (100 nM) or H 2 O 2 (1 mM) for 10 min,

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