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Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer

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Academic year: 2021

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FIGURE 1. IGFBP-3-interacting protein, IGFBP-3R, is a single-span membrane protein and widely expressed in human normal tissue but sup-
FIGURE 2. Specific interaction between IGFBP-3 and IGFBP-3R. A, coimmunoprecipitation of IGFBP-3 F and
FIGURE 4. IGFBP-3R mediates IGFBP-3-induced growth inhibition and apoptosis. A, growth inhibition by adenoviral-transduced IGFBP-3R is shown
FIGURE 5. Potential mechanism of IGFBP-3/IGFBP-3R-induced caspase-dependent apoptosis

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