The Role of Chemokine In Patients With Behcet's Disease According To Clinical Activity

(1)

(2)

(3)

(4)

(5)

(6)

1

-조직학적으로는 진피 혈관 주위에 림프구, 대식

구, 호중구 등의 침윤이 관찰되며 진피의 침윤한 염증세포들 사이에 상호작용에

의해 병변이 생긴다고 알려져 있다.

(7)

(8)

(9)

(10)

(11)

(12)

(13)

(14)

(15)

(16)

(17)

(18)

(19)

(20)

15

(21)

16 -Fig. 1.

(22)

(23)

(24)

(25)

(26)

(27)

(28)

23

-Gene Inactive stage Active stage

I-309 + ++ TECK + ++ TARK + ++ MIP-1β + ++ SCM 1β - + RANTES - + CCR1 - + CCR4 ++ + CXCR4 - + CX3CR1 - + IL1β _ + IL9 + ++ IL16 _ + IL2Rα - + IL2Rγ - + IL13Rγ1 - + IL17R + ++

(29)

(30)

(31)

(32)

27 -C X -C R 4 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1 2 3 4 5

Relative mRNA expression

Active BD Inactive BD B M I P - 1 β 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 1 2 3 4 5

Relative mRNA expression

I - 3 0 9 0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 1 2 3 4 5

(33)

28 -Diagnosis (n=5) Mean ± SD CXCR4 MIP-1β I-309 Active BD 1.084 ± 0.23 0.913 ± 0.27 0.705 ± 0.39 Inactive BD 0.797 ± 0.13* 0.785 ± 0.18* 0.566 ± 0.15

(34)

(35)

(36)

31

-CXCR4 Dermis Epidermis

BD Psoriasis Normal BD Psoriasis Normal

- 2/6 1/2 1/2 6/6 2/2 2/2

(37)

(38)

33

-MIP-1β Dermis Epidermis

- 2/6 2/2 1/2 1/2

+ 4/6 1/2 3/6 1/2

(39)

(40)

35

-I-309 Dermis Epidermis

- 2/2 2/2

+ 1/6

(41)

(42)

(43)

(44)

(45)

(46)

(47)

(48)

(49)

(50)

(51)

(52)

(53)